Assessment of the retinal vasculature in healthy Chinese preschool children aged 4–6 years old using optical coherence tomography angiography

Abstract Purpose To establish normal parameters of macular and optic disc vasculature by optical coherence tomography angiography (OCTA) in healthy preschool children aged 4–6 years old in China. OCTA reflects retinal metabolism and development in children at these ages and could be used clinically...

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Autores principales:	Lu Xiang, Yingming Zhou, Yanwei Chen, Siyu Jiang, Chunli Fei, Yangyang Wang, Yang Bai, Xuan Zhang, Kai Li, Xi Shen
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Healthy preschool children1 Optical coherence tomography angiography2 Vessel density3 Macula4 Optic disc5 Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/67797cc52f144f4a9b9f58f5e9900b9a
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spelling	oai:doaj.org-article:67797cc52f144f4a9b9f58f5e9900b9a2021-12-05T12:26:38ZAssessment of the retinal vasculature in healthy Chinese preschool children aged 4–6 years old using optical coherence tomography angiography10.1186/s12886-021-02154-41471-2415https://doaj.org/article/67797cc52f144f4a9b9f58f5e9900b9a2021-12-01T00:00:00Zhttps://doi.org/10.1186/s12886-021-02154-4https://doaj.org/toc/1471-2415Abstract Purpose To establish normal parameters of macular and optic disc vasculature by optical coherence tomography angiography (OCTA) in healthy preschool children aged 4–6 years old in China. OCTA reflects retinal metabolism and development in children at these ages and could be used clinically and in future studies to aid diagnosis and prediction of retinal abnormalities and developmental stagnation. Methods In this cross-sectional study, we measured foveal, parafoveal, and perifoveal vessel density in the superficial capillary plexus (SCP); the deep capillary plexus (DCP), the foveal avascular zone (FAZ), and the radial capillary peripapillary (RPC) in the optic disc using investigational spectral-domain OCTA. The magnification effect of the FAZ area and microvasculature measurements was corrected by Littman and the modified Bennett formula. Results A total of 242 eyes (116 males and 126 females, 5.31 ± 0.73 years) were recruited for the analysis. The mean macular vessel density was 48.10 ± 2.92% and 48.74 ± 6.51% in the SCP and the DCP, respectively. The RPC vessel density was 47.17 ± 2.52%, 47.99 ± 4.48%, and 48.41 ± 3.07% in the whole image, inside disc, and peripapillary, respectively; and the mean FAZ area was 0.28 ± 0.11 mm2. A significant difference between male and female participants was found in the retinal vasculature (DCP, SCP, and RPC). None of these parameters were significantly different in age (P > 0.05), except that DCP slightly increased with aging. The right and left eyes had good consistency in the parameters of the macula and optic disc. Conclusions Our study establishes the macular and optic disc OCTA reference values in 4- to 6-year-old healthy preschool children. They may be used in longitudinal OCTA studies and clinical applications.Lu XiangYingming ZhouYanwei ChenSiyu JiangChunli FeiYangyang WangYang BaiXuan ZhangKai LiXi ShenBMCarticleHealthy preschool children1Optical coherence tomography angiography2Vessel density3Macula4Optic disc5OphthalmologyRE1-994ENBMC Ophthalmology, Vol 21, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Healthy preschool children1 Optical coherence tomography angiography2 Vessel density3 Macula4 Optic disc5 Ophthalmology RE1-994
spellingShingle	Healthy preschool children1 Optical coherence tomography angiography2 Vessel density3 Macula4 Optic disc5 Ophthalmology RE1-994 Lu Xiang Yingming Zhou Yanwei Chen Siyu Jiang Chunli Fei Yangyang Wang Yang Bai Xuan Zhang Kai Li Xi Shen Assessment of the retinal vasculature in healthy Chinese preschool children aged 4–6 years old using optical coherence tomography angiography
description	Abstract Purpose To establish normal parameters of macular and optic disc vasculature by optical coherence tomography angiography (OCTA) in healthy preschool children aged 4–6 years old in China. OCTA reflects retinal metabolism and development in children at these ages and could be used clinically and in future studies to aid diagnosis and prediction of retinal abnormalities and developmental stagnation. Methods In this cross-sectional study, we measured foveal, parafoveal, and perifoveal vessel density in the superficial capillary plexus (SCP); the deep capillary plexus (DCP), the foveal avascular zone (FAZ), and the radial capillary peripapillary (RPC) in the optic disc using investigational spectral-domain OCTA. The magnification effect of the FAZ area and microvasculature measurements was corrected by Littman and the modified Bennett formula. Results A total of 242 eyes (116 males and 126 females, 5.31 ± 0.73 years) were recruited for the analysis. The mean macular vessel density was 48.10 ± 2.92% and 48.74 ± 6.51% in the SCP and the DCP, respectively. The RPC vessel density was 47.17 ± 2.52%, 47.99 ± 4.48%, and 48.41 ± 3.07% in the whole image, inside disc, and peripapillary, respectively; and the mean FAZ area was 0.28 ± 0.11 mm2. A significant difference between male and female participants was found in the retinal vasculature (DCP, SCP, and RPC). None of these parameters were significantly different in age (P > 0.05), except that DCP slightly increased with aging. The right and left eyes had good consistency in the parameters of the macula and optic disc. Conclusions Our study establishes the macular and optic disc OCTA reference values in 4- to 6-year-old healthy preschool children. They may be used in longitudinal OCTA studies and clinical applications.
format	article
author	Lu Xiang Yingming Zhou Yanwei Chen Siyu Jiang Chunli Fei Yangyang Wang Yang Bai Xuan Zhang Kai Li Xi Shen
author_facet	Lu Xiang Yingming Zhou Yanwei Chen Siyu Jiang Chunli Fei Yangyang Wang Yang Bai Xuan Zhang Kai Li Xi Shen
author_sort	Lu Xiang
title	Assessment of the retinal vasculature in healthy Chinese preschool children aged 4–6 years old using optical coherence tomography angiography
title_short	Assessment of the retinal vasculature in healthy Chinese preschool children aged 4–6 years old using optical coherence tomography angiography
title_full	Assessment of the retinal vasculature in healthy Chinese preschool children aged 4–6 years old using optical coherence tomography angiography
title_fullStr	Assessment of the retinal vasculature in healthy Chinese preschool children aged 4–6 years old using optical coherence tomography angiography
title_full_unstemmed	Assessment of the retinal vasculature in healthy Chinese preschool children aged 4–6 years old using optical coherence tomography angiography
title_sort	assessment of the retinal vasculature in healthy chinese preschool children aged 4–6 years old using optical coherence tomography angiography
publisher	BMC
publishDate	2021
url	https://doaj.org/article/67797cc52f144f4a9b9f58f5e9900b9a
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Assessment of the retinal vasculature in healthy Chinese preschool children aged 4–6 years old using optical coherence tomography angiography

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