Brain solute transport is more rapid in periarterial than perivenous spaces

Abstract Fluid flow in perivascular spaces is recognized as a key component underlying brain transport and clearance. An important open question is how and to what extent differences in vessel type or geometry affect perivascular fluid flow and transport. Using computational modelling in both ideali...

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Autores principales:	Vegard Vinje, Erik N. T. P. Bakker, Marie E. Rognes
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/6785bff7681145cf962bd50ea6d5e51a
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id	oai:doaj.org-article:6785bff7681145cf962bd50ea6d5e51a
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spelling	oai:doaj.org-article:6785bff7681145cf962bd50ea6d5e51a2021-12-02T16:28:50ZBrain solute transport is more rapid in periarterial than perivenous spaces10.1038/s41598-021-95306-x2045-2322https://doaj.org/article/6785bff7681145cf962bd50ea6d5e51a2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95306-xhttps://doaj.org/toc/2045-2322Abstract Fluid flow in perivascular spaces is recognized as a key component underlying brain transport and clearance. An important open question is how and to what extent differences in vessel type or geometry affect perivascular fluid flow and transport. Using computational modelling in both idealized and image-based geometries, we study and compare fluid flow and solute transport in pial (surface) periarterial and perivenous spaces. Our findings demonstrate that differences in geometry between arterial and venous pial perivascular spaces (PVSs) lead to higher net CSF flow, more rapid tracer transport and earlier arrival times of injected tracers in periarterial spaces compared to perivenous spaces. These findings can explain the experimentally observed rapid appearance of tracers around arteries, and the delayed appearance around veins without the need of a circulation through the parenchyma, but rather by direct transport along the PVSs.Vegard VinjeErik N. T. P. BakkerMarie E. RognesNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vegard Vinje Erik N. T. P. Bakker Marie E. Rognes Brain solute transport is more rapid in periarterial than perivenous spaces
description	Abstract Fluid flow in perivascular spaces is recognized as a key component underlying brain transport and clearance. An important open question is how and to what extent differences in vessel type or geometry affect perivascular fluid flow and transport. Using computational modelling in both idealized and image-based geometries, we study and compare fluid flow and solute transport in pial (surface) periarterial and perivenous spaces. Our findings demonstrate that differences in geometry between arterial and venous pial perivascular spaces (PVSs) lead to higher net CSF flow, more rapid tracer transport and earlier arrival times of injected tracers in periarterial spaces compared to perivenous spaces. These findings can explain the experimentally observed rapid appearance of tracers around arteries, and the delayed appearance around veins without the need of a circulation through the parenchyma, but rather by direct transport along the PVSs.
format	article
author	Vegard Vinje Erik N. T. P. Bakker Marie E. Rognes
author_facet	Vegard Vinje Erik N. T. P. Bakker Marie E. Rognes
author_sort	Vegard Vinje
title	Brain solute transport is more rapid in periarterial than perivenous spaces
title_short	Brain solute transport is more rapid in periarterial than perivenous spaces
title_full	Brain solute transport is more rapid in periarterial than perivenous spaces
title_fullStr	Brain solute transport is more rapid in periarterial than perivenous spaces
title_full_unstemmed	Brain solute transport is more rapid in periarterial than perivenous spaces
title_sort	brain solute transport is more rapid in periarterial than perivenous spaces
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/6785bff7681145cf962bd50ea6d5e51a
work_keys_str_mv	AT vegardvinje brainsolutetransportismorerapidinperiarterialthanperivenousspaces AT erikntpbakker brainsolutetransportismorerapidinperiarterialthanperivenousspaces AT marieerognes brainsolutetransportismorerapidinperiarterialthanperivenousspaces
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Brain solute transport is more rapid in periarterial than perivenous spaces

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