Wellbeing, quality of life, presence of concurrent diseases, and survival times in untreated and treated German Shepherd dogs with dwarfism.

<h4>Background</h4>Pituitary dwarfism (PD) in German Shepherd dogs (GSD) is a rare endocrinopathy. Cause and inheritance of the disease are well characterized, but the overall survival time, presence of concurrent diseases, quality of life (QoL) and influence of different treatment optio...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Stefanie Kitzmann, Katrin Hartmann, Yury Zablotski, Anna Rieger, Ralf Mueller, Astrid Wehner
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/67883378f99443e7bd5d5bc143927e57
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:67883378f99443e7bd5d5bc143927e57
record_format	dspace
spelling	oai:doaj.org-article:67883378f99443e7bd5d5bc143927e572021-12-02T20:15:07ZWellbeing, quality of life, presence of concurrent diseases, and survival times in untreated and treated German Shepherd dogs with dwarfism.1932-620310.1371/journal.pone.0255678https://doaj.org/article/67883378f99443e7bd5d5bc143927e572021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0255678https://doaj.org/toc/1932-6203<h4>Background</h4>Pituitary dwarfism (PD) in German Shepherd dogs (GSD) is a rare endocrinopathy. Cause and inheritance of the disease are well characterized, but the overall survival time, presence of concurrent diseases, quality of life (QoL) and influence of different treatment options on those parameters is still not well investigated. The aim of this study was to obtain data regarding the disease pattern of GSD with PD and to investigate the impact of treatment.<h4>Methods</h4>47 dogs with dwarfism (presumably PD) and 94 unaffected GSD serving as controls were enrolled. Data were collected via a standardized questionnaire, which every owner of a participating dog had completed. Dogs with PD were grouped based on three categories of treatment: Group 1 (untreated), group 2 (treated with levothyroxine), group 3 (treated with thyroxine and progestogens or with growth hormone (GH)). Groups were compared using One-Way-Anova, Kruskal-Wallis test or Wilcoxon-rank-sum test. Categorical analysis was performed using Two-Sample-Chi-Squared-test.<h4>Results</h4>Dogs treated with thyroxine and gestagen or GH were significantly taller and heavier compared to all other dogs with PD. Quality of life was best in dogs with PD treated with thyroxine and similar to unaffected GSD. Treatment increased survival time in dogs with PD independent of the treatment strategy. Dogs receiving thyroxine and progestogens or GH did not develop chronic kidney disease (CKD).<h4>Conclusion</h4>GSD with PD should be treated at least for their secondary hypothyroidism to increase survival time. Additional treatment with progestogens or GH improves body size and seems to protect against the occurrence of CKD.Stefanie KitzmannKatrin HartmannYury ZablotskiAnna RiegerRalf MuellerAstrid WehnerPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 8, p e0255678 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Stefanie Kitzmann Katrin Hartmann Yury Zablotski Anna Rieger Ralf Mueller Astrid Wehner Wellbeing, quality of life, presence of concurrent diseases, and survival times in untreated and treated German Shepherd dogs with dwarfism.
description	<h4>Background</h4>Pituitary dwarfism (PD) in German Shepherd dogs (GSD) is a rare endocrinopathy. Cause and inheritance of the disease are well characterized, but the overall survival time, presence of concurrent diseases, quality of life (QoL) and influence of different treatment options on those parameters is still not well investigated. The aim of this study was to obtain data regarding the disease pattern of GSD with PD and to investigate the impact of treatment.<h4>Methods</h4>47 dogs with dwarfism (presumably PD) and 94 unaffected GSD serving as controls were enrolled. Data were collected via a standardized questionnaire, which every owner of a participating dog had completed. Dogs with PD were grouped based on three categories of treatment: Group 1 (untreated), group 2 (treated with levothyroxine), group 3 (treated with thyroxine and progestogens or with growth hormone (GH)). Groups were compared using One-Way-Anova, Kruskal-Wallis test or Wilcoxon-rank-sum test. Categorical analysis was performed using Two-Sample-Chi-Squared-test.<h4>Results</h4>Dogs treated with thyroxine and gestagen or GH were significantly taller and heavier compared to all other dogs with PD. Quality of life was best in dogs with PD treated with thyroxine and similar to unaffected GSD. Treatment increased survival time in dogs with PD independent of the treatment strategy. Dogs receiving thyroxine and progestogens or GH did not develop chronic kidney disease (CKD).<h4>Conclusion</h4>GSD with PD should be treated at least for their secondary hypothyroidism to increase survival time. Additional treatment with progestogens or GH improves body size and seems to protect against the occurrence of CKD.
format	article
author	Stefanie Kitzmann Katrin Hartmann Yury Zablotski Anna Rieger Ralf Mueller Astrid Wehner
author_facet	Stefanie Kitzmann Katrin Hartmann Yury Zablotski Anna Rieger Ralf Mueller Astrid Wehner
author_sort	Stefanie Kitzmann
title	Wellbeing, quality of life, presence of concurrent diseases, and survival times in untreated and treated German Shepherd dogs with dwarfism.
title_short	Wellbeing, quality of life, presence of concurrent diseases, and survival times in untreated and treated German Shepherd dogs with dwarfism.
title_full	Wellbeing, quality of life, presence of concurrent diseases, and survival times in untreated and treated German Shepherd dogs with dwarfism.
title_fullStr	Wellbeing, quality of life, presence of concurrent diseases, and survival times in untreated and treated German Shepherd dogs with dwarfism.
title_full_unstemmed	Wellbeing, quality of life, presence of concurrent diseases, and survival times in untreated and treated German Shepherd dogs with dwarfism.
title_sort	wellbeing, quality of life, presence of concurrent diseases, and survival times in untreated and treated german shepherd dogs with dwarfism.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/67883378f99443e7bd5d5bc143927e57
work_keys_str_mv	AT stefaniekitzmann wellbeingqualityoflifepresenceofconcurrentdiseasesandsurvivaltimesinuntreatedandtreatedgermanshepherddogswithdwarfism AT katrinhartmann wellbeingqualityoflifepresenceofconcurrentdiseasesandsurvivaltimesinuntreatedandtreatedgermanshepherddogswithdwarfism AT yuryzablotski wellbeingqualityoflifepresenceofconcurrentdiseasesandsurvivaltimesinuntreatedandtreatedgermanshepherddogswithdwarfism AT annarieger wellbeingqualityoflifepresenceofconcurrentdiseasesandsurvivaltimesinuntreatedandtreatedgermanshepherddogswithdwarfism AT ralfmueller wellbeingqualityoflifepresenceofconcurrentdiseasesandsurvivaltimesinuntreatedandtreatedgermanshepherddogswithdwarfism AT astridwehner wellbeingqualityoflifepresenceofconcurrentdiseasesandsurvivaltimesinuntreatedandtreatedgermanshepherddogswithdwarfism
_version_	1718374586170474496

Wellbeing, quality of life, presence of concurrent diseases, and survival times in untreated and treated German Shepherd dogs with dwarfism.

Ejemplares similares