Vasoactive intestinal polypeptide plasma levels associated with affective symptoms and brain structure and function in healthy females

Abstract Vasoactive intestinal polypeptide (VIP) is a neuroendocrine peptide distributed throughout the human body, including the CNS, where it is particularly abundant in brain regions associated with anxiety and depression. Based on earlier studies indicating that peripheral VIP may cross through...

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Autores principales:	Rozalyn A. Simon, Nawroz Barazanji, Michael P. Jones, Olga Bednarska, Adriane Icenhour, Maria Engström, J. Paul Hamilton, Åsa V. Keita, Susanna Walter
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/678a1728f56d44d58d47f1c9be74aef2
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spelling	oai:doaj.org-article:678a1728f56d44d58d47f1c9be74aef22021-12-02T14:12:46ZVasoactive intestinal polypeptide plasma levels associated with affective symptoms and brain structure and function in healthy females10.1038/s41598-020-80873-22045-2322https://doaj.org/article/678a1728f56d44d58d47f1c9be74aef22021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-80873-2https://doaj.org/toc/2045-2322Abstract Vasoactive intestinal polypeptide (VIP) is a neuroendocrine peptide distributed throughout the human body, including the CNS, where it is particularly abundant in brain regions associated with anxiety and depression. Based on earlier studies indicating that peripheral VIP may cross through the blood–brain barrier, we hypothesized plasma VIP levels to be associated with symptoms of anxiety and depression, as well as brain volume and resting-state functional connectivity in the amygdala, hippocampus, parahippocampus, and orbitofrontal cortex. Plasma VIP concentrations and anxiety/depression symptoms were measured in 37 healthy females. Functional and structural magnetic resonance imaging were used to evaluate functional connectivity and brain volume respectively, and their associations with VIP concentrations within brain regions associated with anxiety and depression. Negative correlations were found between VIP levels and symptoms of anxiety (r = − 0.44, p = 0.002) and depression (r = − 0.50, p = 0.001). Functional connectivity demonstrated significant VIP-dependent positive associations between the amygdala seed region with both the right parahippocampus (t (33) = 3.1, p FDR = 0.02) and right lateral orbitofrontal cortex (OFC; t (33) = 2.9, p FDR = 0.02). Moreover, VIP concentrations were significantly, positively correlated with brain volume in the left amygdala (r = 0.28, p = 0.007) and left lateral OFC (r = 0.29, p = 0.004). The present findings highlight a potential role for VIP in the neurobiology of affective symptoms.Rozalyn A. SimonNawroz BarazanjiMichael P. JonesOlga BednarskaAdriane IcenhourMaria EngströmJ. Paul HamiltonÅsa V. KeitaSusanna WalterNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Rozalyn A. Simon Nawroz Barazanji Michael P. Jones Olga Bednarska Adriane Icenhour Maria Engström J. Paul Hamilton Åsa V. Keita Susanna Walter Vasoactive intestinal polypeptide plasma levels associated with affective symptoms and brain structure and function in healthy females
description	Abstract Vasoactive intestinal polypeptide (VIP) is a neuroendocrine peptide distributed throughout the human body, including the CNS, where it is particularly abundant in brain regions associated with anxiety and depression. Based on earlier studies indicating that peripheral VIP may cross through the blood–brain barrier, we hypothesized plasma VIP levels to be associated with symptoms of anxiety and depression, as well as brain volume and resting-state functional connectivity in the amygdala, hippocampus, parahippocampus, and orbitofrontal cortex. Plasma VIP concentrations and anxiety/depression symptoms were measured in 37 healthy females. Functional and structural magnetic resonance imaging were used to evaluate functional connectivity and brain volume respectively, and their associations with VIP concentrations within brain regions associated with anxiety and depression. Negative correlations were found between VIP levels and symptoms of anxiety (r = − 0.44, p = 0.002) and depression (r = − 0.50, p = 0.001). Functional connectivity demonstrated significant VIP-dependent positive associations between the amygdala seed region with both the right parahippocampus (t (33) = 3.1, p FDR = 0.02) and right lateral orbitofrontal cortex (OFC; t (33) = 2.9, p FDR = 0.02). Moreover, VIP concentrations were significantly, positively correlated with brain volume in the left amygdala (r = 0.28, p = 0.007) and left lateral OFC (r = 0.29, p = 0.004). The present findings highlight a potential role for VIP in the neurobiology of affective symptoms.
format	article
author	Rozalyn A. Simon Nawroz Barazanji Michael P. Jones Olga Bednarska Adriane Icenhour Maria Engström J. Paul Hamilton Åsa V. Keita Susanna Walter
author_facet	Rozalyn A. Simon Nawroz Barazanji Michael P. Jones Olga Bednarska Adriane Icenhour Maria Engström J. Paul Hamilton Åsa V. Keita Susanna Walter
author_sort	Rozalyn A. Simon
title	Vasoactive intestinal polypeptide plasma levels associated with affective symptoms and brain structure and function in healthy females
title_short	Vasoactive intestinal polypeptide plasma levels associated with affective symptoms and brain structure and function in healthy females
title_full	Vasoactive intestinal polypeptide plasma levels associated with affective symptoms and brain structure and function in healthy females
title_fullStr	Vasoactive intestinal polypeptide plasma levels associated with affective symptoms and brain structure and function in healthy females
title_full_unstemmed	Vasoactive intestinal polypeptide plasma levels associated with affective symptoms and brain structure and function in healthy females
title_sort	vasoactive intestinal polypeptide plasma levels associated with affective symptoms and brain structure and function in healthy females
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/678a1728f56d44d58d47f1c9be74aef2
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Vasoactive intestinal polypeptide plasma levels associated with affective symptoms and brain structure and function in healthy females

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