Monoclonal gammopathy of undetermined significance and COVID-19: a population-based cohort study

Abstract Multiple myeloma (MM) patients have increased risk of severe coronavirus disease 2019 (COVID-19) when infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Monoclonal gammopathy of undetermined significance (MGUS), the precursor of MM has been associated with immune dysf...

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Autores principales:	Saemundur Rognvaldsson, Elias Eythorsson, Sigrun Thorsteinsdottir, Brynjar Vidarsson, Pall Torfi Onundarson, Bjarni A. Agnarsson, Margret Sigurdardottir, Ingunn Thorsteinsdóttir, Isleifur Olafsson, Hrafnhildur L. Runolfsdottir, Dadi Helgason, Arna R. Emilsdottir, Arnar S. Agustsson, Aron H. Bjornsson, Gudrun Kristjansdottir, Asdis Rosa Thordardottir, Olafur Skuli Indridason, Asbjorn Jonsson, Gauti Kjartan Gislason, Andri Olafsson, Hlif Steingrimsdottir, Petros Kampanis, Malin Hultcrantz, Brian G. M. Durie, Stephen Harding, Ola Landgren, Runolfur Palsson, Thorvarður Jon Love, Sigurdur Yngvi Kristinsson
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/678b5fd2b3314bf290a0f751eb2a96f8
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spelling	oai:doaj.org-article:678b5fd2b3314bf290a0f751eb2a96f82021-12-05T12:25:51ZMonoclonal gammopathy of undetermined significance and COVID-19: a population-based cohort study10.1038/s41408-021-00580-72044-5385https://doaj.org/article/678b5fd2b3314bf290a0f751eb2a96f82021-12-01T00:00:00Zhttps://doi.org/10.1038/s41408-021-00580-7https://doaj.org/toc/2044-5385Abstract Multiple myeloma (MM) patients have increased risk of severe coronavirus disease 2019 (COVID-19) when infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Monoclonal gammopathy of undetermined significance (MGUS), the precursor of MM has been associated with immune dysfunction which may lead to severe COVID-19. No systematic data have been published on COVID-19 in individuals with MGUS. We conducted a large population-based cohort study evaluating the risk of SARS-CoV-2 infection and severe COVID-19 among individuals with MGUS. We included 75,422 Icelanders born before 1976, who had been screened for MGUS in the Iceland Screens Treats or Prevents Multiple Myeloma study (iStopMM). Data on SARS-CoV-2 testing and COVID-19 severity were acquired from the Icelandic COVID-19 Study Group. Using a test-negative study design, we included 32,047 iStopMM participants who had been tested for SARS-CoV-2, of whom 1754 had MGUS. Among these participants, 1100 participants, tested positive, 65 of whom had MGUS. Severe COVID-19 developed in 230 participants, including 16 with MGUS. MGUS was not associated with SARS-CoV-2 infection (Odds ratio (OR): 1.05; 95% confidence interval (CI): 0.81–1.36; p = 0.72) or severe COVID-19 (OR: 0.99; 95%CI: 0.52–1.91; p = 0.99). These findings indicate that MGUS does not affect the susceptibility to SARS-CoV-2 or the severity of COVID-19.Saemundur RognvaldssonElias EythorssonSigrun ThorsteinsdottirBrynjar VidarssonPall Torfi OnundarsonBjarni A. AgnarssonMargret SigurdardottirIngunn ThorsteinsdóttirIsleifur OlafssonHrafnhildur L. RunolfsdottirDadi HelgasonArna R. EmilsdottirArnar S. AgustssonAron H. BjornssonGudrun KristjansdottirAsdis Rosa ThordardottirOlafur Skuli IndridasonAsbjorn JonssonGauti Kjartan GislasonAndri OlafssonHlif SteingrimsdottirPetros KampanisMalin HultcrantzBrian G. M. DurieStephen HardingOla LandgrenRunolfur PalssonThorvarður Jon LoveSigurdur Yngvi KristinssonNature Publishing GrouparticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBlood Cancer Journal, Vol 11, Iss 12, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Saemundur Rognvaldsson Elias Eythorsson Sigrun Thorsteinsdottir Brynjar Vidarsson Pall Torfi Onundarson Bjarni A. Agnarsson Margret Sigurdardottir Ingunn Thorsteinsdóttir Isleifur Olafsson Hrafnhildur L. Runolfsdottir Dadi Helgason Arna R. Emilsdottir Arnar S. Agustsson Aron H. Bjornsson Gudrun Kristjansdottir Asdis Rosa Thordardottir Olafur Skuli Indridason Asbjorn Jonsson Gauti Kjartan Gislason Andri Olafsson Hlif Steingrimsdottir Petros Kampanis Malin Hultcrantz Brian G. M. Durie Stephen Harding Ola Landgren Runolfur Palsson Thorvarður Jon Love Sigurdur Yngvi Kristinsson Monoclonal gammopathy of undetermined significance and COVID-19: a population-based cohort study
description	Abstract Multiple myeloma (MM) patients have increased risk of severe coronavirus disease 2019 (COVID-19) when infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Monoclonal gammopathy of undetermined significance (MGUS), the precursor of MM has been associated with immune dysfunction which may lead to severe COVID-19. No systematic data have been published on COVID-19 in individuals with MGUS. We conducted a large population-based cohort study evaluating the risk of SARS-CoV-2 infection and severe COVID-19 among individuals with MGUS. We included 75,422 Icelanders born before 1976, who had been screened for MGUS in the Iceland Screens Treats or Prevents Multiple Myeloma study (iStopMM). Data on SARS-CoV-2 testing and COVID-19 severity were acquired from the Icelandic COVID-19 Study Group. Using a test-negative study design, we included 32,047 iStopMM participants who had been tested for SARS-CoV-2, of whom 1754 had MGUS. Among these participants, 1100 participants, tested positive, 65 of whom had MGUS. Severe COVID-19 developed in 230 participants, including 16 with MGUS. MGUS was not associated with SARS-CoV-2 infection (Odds ratio (OR): 1.05; 95% confidence interval (CI): 0.81–1.36; p = 0.72) or severe COVID-19 (OR: 0.99; 95%CI: 0.52–1.91; p = 0.99). These findings indicate that MGUS does not affect the susceptibility to SARS-CoV-2 or the severity of COVID-19.
format	article
author	Saemundur Rognvaldsson Elias Eythorsson Sigrun Thorsteinsdottir Brynjar Vidarsson Pall Torfi Onundarson Bjarni A. Agnarsson Margret Sigurdardottir Ingunn Thorsteinsdóttir Isleifur Olafsson Hrafnhildur L. Runolfsdottir Dadi Helgason Arna R. Emilsdottir Arnar S. Agustsson Aron H. Bjornsson Gudrun Kristjansdottir Asdis Rosa Thordardottir Olafur Skuli Indridason Asbjorn Jonsson Gauti Kjartan Gislason Andri Olafsson Hlif Steingrimsdottir Petros Kampanis Malin Hultcrantz Brian G. M. Durie Stephen Harding Ola Landgren Runolfur Palsson Thorvarður Jon Love Sigurdur Yngvi Kristinsson
author_facet	Saemundur Rognvaldsson Elias Eythorsson Sigrun Thorsteinsdottir Brynjar Vidarsson Pall Torfi Onundarson Bjarni A. Agnarsson Margret Sigurdardottir Ingunn Thorsteinsdóttir Isleifur Olafsson Hrafnhildur L. Runolfsdottir Dadi Helgason Arna R. Emilsdottir Arnar S. Agustsson Aron H. Bjornsson Gudrun Kristjansdottir Asdis Rosa Thordardottir Olafur Skuli Indridason Asbjorn Jonsson Gauti Kjartan Gislason Andri Olafsson Hlif Steingrimsdottir Petros Kampanis Malin Hultcrantz Brian G. M. Durie Stephen Harding Ola Landgren Runolfur Palsson Thorvarður Jon Love Sigurdur Yngvi Kristinsson
author_sort	Saemundur Rognvaldsson
title	Monoclonal gammopathy of undetermined significance and COVID-19: a population-based cohort study
title_short	Monoclonal gammopathy of undetermined significance and COVID-19: a population-based cohort study
title_full	Monoclonal gammopathy of undetermined significance and COVID-19: a population-based cohort study
title_fullStr	Monoclonal gammopathy of undetermined significance and COVID-19: a population-based cohort study
title_full_unstemmed	Monoclonal gammopathy of undetermined significance and COVID-19: a population-based cohort study
title_sort	monoclonal gammopathy of undetermined significance and covid-19: a population-based cohort study
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/678b5fd2b3314bf290a0f751eb2a96f8
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Monoclonal gammopathy of undetermined significance and COVID-19: a population-based cohort study

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