Autophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation

T cell mediated therapies have proven largely unsuccessful in triple-negative breast cancer (TNBC). Here, the authors show that autophagy is reduced in TNBC, which results in an increase in Tenascin C and reduced activation of tumour infiltrating lymphocytes.

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Autores principales:	Zhi-Ling Li, Hai-Liang Zhang, Yun Huang, Jun-Hao Huang, Peng Sun, Ning-Ning Zhou, Yu-Hong Chen, Jia Mai, Yan Wang, Yan Yu, Li-Huan Zhou, Xuan Li, Dong Yang, Xiao-Dan Peng, Gong-Kan Feng, Jun Tang, Xiao-Feng Zhu, Rong Deng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/679056fb338f417b9f0c24912564acaa
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spelling	oai:doaj.org-article:679056fb338f417b9f0c24912564acaa2021-12-02T18:47:08ZAutophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation10.1038/s41467-020-17395-y2041-1723https://doaj.org/article/679056fb338f417b9f0c24912564acaa2020-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17395-yhttps://doaj.org/toc/2041-1723T cell mediated therapies have proven largely unsuccessful in triple-negative breast cancer (TNBC). Here, the authors show that autophagy is reduced in TNBC, which results in an increase in Tenascin C and reduced activation of tumour infiltrating lymphocytes.Zhi-Ling LiHai-Liang ZhangYun HuangJun-Hao HuangPeng SunNing-Ning ZhouYu-Hong ChenJia MaiYan WangYan YuLi-Huan ZhouXuan LiDong YangXiao-Dan PengGong-Kan FengJun TangXiao-Feng ZhuRong DengNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-19 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zhi-Ling Li Hai-Liang Zhang Yun Huang Jun-Hao Huang Peng Sun Ning-Ning Zhou Yu-Hong Chen Jia Mai Yan Wang Yan Yu Li-Huan Zhou Xuan Li Dong Yang Xiao-Dan Peng Gong-Kan Feng Jun Tang Xiao-Feng Zhu Rong Deng Autophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation
description	T cell mediated therapies have proven largely unsuccessful in triple-negative breast cancer (TNBC). Here, the authors show that autophagy is reduced in TNBC, which results in an increase in Tenascin C and reduced activation of tumour infiltrating lymphocytes.
format	article
author	Zhi-Ling Li Hai-Liang Zhang Yun Huang Jun-Hao Huang Peng Sun Ning-Ning Zhou Yu-Hong Chen Jia Mai Yan Wang Yan Yu Li-Huan Zhou Xuan Li Dong Yang Xiao-Dan Peng Gong-Kan Feng Jun Tang Xiao-Feng Zhu Rong Deng
author_facet	Zhi-Ling Li Hai-Liang Zhang Yun Huang Jun-Hao Huang Peng Sun Ning-Ning Zhou Yu-Hong Chen Jia Mai Yan Wang Yan Yu Li-Huan Zhou Xuan Li Dong Yang Xiao-Dan Peng Gong-Kan Feng Jun Tang Xiao-Feng Zhu Rong Deng
author_sort	Zhi-Ling Li
title	Autophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation
title_short	Autophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation
title_full	Autophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation
title_fullStr	Autophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation
title_full_unstemmed	Autophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation
title_sort	autophagy deficiency promotes triple-negative breast cancer resistance to t cell-mediated cytotoxicity by blocking tenascin-c degradation
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/679056fb338f417b9f0c24912564acaa
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Autophagy deficiency promotes triple-negative breast cancer resistance to T cell-mediated cytotoxicity by blocking tenascin-C degradation

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