IL-17-producing γδ T cells enhance bone regeneration

γδ T cells are innate-like lymphocytes that regulate immune responses by producing IL-17A or IFN-γ, but have no known role in bone healing. Here the authors show a nonimmune bone-regenerative function of IL-17A produced by the Vγ6+ subset in mice.

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Detalles Bibliográficos
Autores principales: Takehito Ono, Kazuo Okamoto, Tomoki Nakashima, Takeshi Nitta, Shohei Hori, Yoichiro Iwakura, Hiroshi Takayanagi
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/679616e474a54998a71bde011fcf764b
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Descripción
Sumario:γδ T cells are innate-like lymphocytes that regulate immune responses by producing IL-17A or IFN-γ, but have no known role in bone healing. Here the authors show a nonimmune bone-regenerative function of IL-17A produced by the Vγ6+ subset in mice.