Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants

While most kinases are ATP-dependent some utilize pyrophosphate (PPi) instead. Here the authors structurally characterize a PPi-dependent kinase, identify its key recognition residues and find further PPi-dependent ribokinase family members with this signature pattern.

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Autores principales: Ryuhei Nagata, Masahiro Fujihashi, Takaaki Sato, Haruyuki Atomi, Kunio Miki
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/679a3de9b2dc42ffa99617e22a2f9161
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spelling oai:doaj.org-article:679a3de9b2dc42ffa99617e22a2f91612021-12-02T14:40:44ZIdentification of a pyrophosphate-dependent kinase and its donor selectivity determinants10.1038/s41467-018-04201-z2041-1723https://doaj.org/article/679a3de9b2dc42ffa99617e22a2f91612018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04201-zhttps://doaj.org/toc/2041-1723While most kinases are ATP-dependent some utilize pyrophosphate (PPi) instead. Here the authors structurally characterize a PPi-dependent kinase, identify its key recognition residues and find further PPi-dependent ribokinase family members with this signature pattern.Ryuhei NagataMasahiro FujihashiTakaaki SatoHaruyuki AtomiKunio MikiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Ryuhei Nagata
Masahiro Fujihashi
Takaaki Sato
Haruyuki Atomi
Kunio Miki
Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants
description While most kinases are ATP-dependent some utilize pyrophosphate (PPi) instead. Here the authors structurally characterize a PPi-dependent kinase, identify its key recognition residues and find further PPi-dependent ribokinase family members with this signature pattern.
format article
author Ryuhei Nagata
Masahiro Fujihashi
Takaaki Sato
Haruyuki Atomi
Kunio Miki
author_facet Ryuhei Nagata
Masahiro Fujihashi
Takaaki Sato
Haruyuki Atomi
Kunio Miki
author_sort Ryuhei Nagata
title Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants
title_short Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants
title_full Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants
title_fullStr Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants
title_full_unstemmed Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants
title_sort identification of a pyrophosphate-dependent kinase and its donor selectivity determinants
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/679a3de9b2dc42ffa99617e22a2f9161
work_keys_str_mv AT ryuheinagata identificationofapyrophosphatedependentkinaseanditsdonorselectivitydeterminants
AT masahirofujihashi identificationofapyrophosphatedependentkinaseanditsdonorselectivitydeterminants
AT takaakisato identificationofapyrophosphatedependentkinaseanditsdonorselectivitydeterminants
AT haruyukiatomi identificationofapyrophosphatedependentkinaseanditsdonorselectivitydeterminants
AT kuniomiki identificationofapyrophosphatedependentkinaseanditsdonorselectivitydeterminants
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