Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants

While most kinases are ATP-dependent some utilize pyrophosphate (PPi) instead. Here the authors structurally characterize a PPi-dependent kinase, identify its key recognition residues and find further PPi-dependent ribokinase family members with this signature pattern.

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Autores principales:	Ryuhei Nagata, Masahiro Fujihashi, Takaaki Sato, Haruyuki Atomi, Kunio Miki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/679a3de9b2dc42ffa99617e22a2f9161
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spelling	oai:doaj.org-article:679a3de9b2dc42ffa99617e22a2f91612021-12-02T14:40:44ZIdentification of a pyrophosphate-dependent kinase and its donor selectivity determinants10.1038/s41467-018-04201-z2041-1723https://doaj.org/article/679a3de9b2dc42ffa99617e22a2f91612018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04201-zhttps://doaj.org/toc/2041-1723While most kinases are ATP-dependent some utilize pyrophosphate (PPi) instead. Here the authors structurally characterize a PPi-dependent kinase, identify its key recognition residues and find further PPi-dependent ribokinase family members with this signature pattern.Ryuhei NagataMasahiro FujihashiTakaaki SatoHaruyuki AtomiKunio MikiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ryuhei Nagata Masahiro Fujihashi Takaaki Sato Haruyuki Atomi Kunio Miki Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants
description	While most kinases are ATP-dependent some utilize pyrophosphate (PPi) instead. Here the authors structurally characterize a PPi-dependent kinase, identify its key recognition residues and find further PPi-dependent ribokinase family members with this signature pattern.
format	article
author	Ryuhei Nagata Masahiro Fujihashi Takaaki Sato Haruyuki Atomi Kunio Miki
author_facet	Ryuhei Nagata Masahiro Fujihashi Takaaki Sato Haruyuki Atomi Kunio Miki
author_sort	Ryuhei Nagata
title	Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants
title_short	Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants
title_full	Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants
title_fullStr	Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants
title_full_unstemmed	Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants
title_sort	identification of a pyrophosphate-dependent kinase and its donor selectivity determinants
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/679a3de9b2dc42ffa99617e22a2f9161
work_keys_str_mv	AT ryuheinagata identificationofapyrophosphatedependentkinaseanditsdonorselectivitydeterminants AT masahirofujihashi identificationofapyrophosphatedependentkinaseanditsdonorselectivitydeterminants AT takaakisato identificationofapyrophosphatedependentkinaseanditsdonorselectivitydeterminants AT haruyukiatomi identificationofapyrophosphatedependentkinaseanditsdonorselectivitydeterminants AT kuniomiki identificationofapyrophosphatedependentkinaseanditsdonorselectivitydeterminants
_version_	1718390177931460608

Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants

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