Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants
While most kinases are ATP-dependent some utilize pyrophosphate (PPi) instead. Here the authors structurally characterize a PPi-dependent kinase, identify its key recognition residues and find further PPi-dependent ribokinase family members with this signature pattern.
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Nature Portfolio
2018
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oai:doaj.org-article:679a3de9b2dc42ffa99617e22a2f91612021-12-02T14:40:44ZIdentification of a pyrophosphate-dependent kinase and its donor selectivity determinants10.1038/s41467-018-04201-z2041-1723https://doaj.org/article/679a3de9b2dc42ffa99617e22a2f91612018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04201-zhttps://doaj.org/toc/2041-1723While most kinases are ATP-dependent some utilize pyrophosphate (PPi) instead. Here the authors structurally characterize a PPi-dependent kinase, identify its key recognition residues and find further PPi-dependent ribokinase family members with this signature pattern.Ryuhei NagataMasahiro FujihashiTakaaki SatoHaruyuki AtomiKunio MikiNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-8 (2018) |
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Science Q Ryuhei Nagata Masahiro Fujihashi Takaaki Sato Haruyuki Atomi Kunio Miki Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants |
description |
While most kinases are ATP-dependent some utilize pyrophosphate (PPi) instead. Here the authors structurally characterize a PPi-dependent kinase, identify its key recognition residues and find further PPi-dependent ribokinase family members with this signature pattern. |
format |
article |
author |
Ryuhei Nagata Masahiro Fujihashi Takaaki Sato Haruyuki Atomi Kunio Miki |
author_facet |
Ryuhei Nagata Masahiro Fujihashi Takaaki Sato Haruyuki Atomi Kunio Miki |
author_sort |
Ryuhei Nagata |
title |
Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants |
title_short |
Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants |
title_full |
Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants |
title_fullStr |
Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants |
title_full_unstemmed |
Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants |
title_sort |
identification of a pyrophosphate-dependent kinase and its donor selectivity determinants |
publisher |
Nature Portfolio |
publishDate |
2018 |
url |
https://doaj.org/article/679a3de9b2dc42ffa99617e22a2f9161 |
work_keys_str_mv |
AT ryuheinagata identificationofapyrophosphatedependentkinaseanditsdonorselectivitydeterminants AT masahirofujihashi identificationofapyrophosphatedependentkinaseanditsdonorselectivitydeterminants AT takaakisato identificationofapyrophosphatedependentkinaseanditsdonorselectivitydeterminants AT haruyukiatomi identificationofapyrophosphatedependentkinaseanditsdonorselectivitydeterminants AT kuniomiki identificationofapyrophosphatedependentkinaseanditsdonorselectivitydeterminants |
_version_ |
1718390177931460608 |