Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants

Identification of a pyrophosphate-dependent kinase and its donor selectivity determinants

While most kinases are ATP-dependent some utilize pyrophosphate (PPi) instead. Here the authors structurally characterize a PPi-dependent kinase, identify its key recognition residues and find further PPi-dependent ribokinase family members with this signature pattern.

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Detalles Bibliográficos
Autores principales: Ryuhei Nagata, Masahiro Fujihashi, Takaaki Sato, Haruyuki Atomi, Kunio Miki
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
Materias:
Science
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Acceso en línea:https://doaj.org/article/679a3de9b2dc42ffa99617e22a2f9161
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