Ischemic tolerance and cardiac repair in the spiny mouse (Acomys)

Abstract Ischemic heart disease and by extension myocardial infarction is the primary cause of death worldwide, warranting regenerative therapies to restore heart function. Current models of natural heart regeneration are restricted in that they are not of adult mammalian origin, precluding the stud...

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Autores principales:	Tim Koopmans, Henriette van Beijnum, Elke F. Roovers, Antonio Tomasso, Divyanshu Malhotra, Jochem Boeter, Olympia E. Psathaki, Danielle Versteeg, Eva van Rooij, Kerstin Bartscherer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R
Acceso en línea:	https://doaj.org/article/679c838b47c14a9493266eb88940b458
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spelling	oai:doaj.org-article:679c838b47c14a9493266eb88940b4582021-11-21T12:40:29ZIschemic tolerance and cardiac repair in the spiny mouse (Acomys)10.1038/s41536-021-00188-22057-3995https://doaj.org/article/679c838b47c14a9493266eb88940b4582021-11-01T00:00:00Zhttps://doi.org/10.1038/s41536-021-00188-2https://doaj.org/toc/2057-3995Abstract Ischemic heart disease and by extension myocardial infarction is the primary cause of death worldwide, warranting regenerative therapies to restore heart function. Current models of natural heart regeneration are restricted in that they are not of adult mammalian origin, precluding the study of class-specific traits that have emerged throughout evolution, and reducing translatability of research findings to humans. Here, we present the spiny mouse (Acomys spp.), a murid rodent that exhibits bona fide regeneration of the back skin and ear pinna, as a model to study heart repair. By comparing them to ordinary mice (Mus musculus), we show that the acute injury response in spiny mice is similar, but with an associated tolerance to infarction through superior survivability, improved ventricular conduction, and near-absence of pathological remodeling. Critically, spiny mice display increased vascularization, altered scar organization, and a more immature phenotype of cardiomyocytes, with a corresponding improvement in heart function. These findings present new avenues for mammalian heart research by leveraging unique tissue properties of the spiny mouse.Tim KoopmansHenriette van BeijnumElke F. RooversAntonio TomassoDivyanshu MalhotraJochem BoeterOlympia E. PsathakiDanielle VersteegEva van RooijKerstin BartschererNature PortfolioarticleMedicineRENnpj Regenerative Medicine, Vol 6, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R
spellingShingle	Medicine R Tim Koopmans Henriette van Beijnum Elke F. Roovers Antonio Tomasso Divyanshu Malhotra Jochem Boeter Olympia E. Psathaki Danielle Versteeg Eva van Rooij Kerstin Bartscherer Ischemic tolerance and cardiac repair in the spiny mouse (Acomys)
description	Abstract Ischemic heart disease and by extension myocardial infarction is the primary cause of death worldwide, warranting regenerative therapies to restore heart function. Current models of natural heart regeneration are restricted in that they are not of adult mammalian origin, precluding the study of class-specific traits that have emerged throughout evolution, and reducing translatability of research findings to humans. Here, we present the spiny mouse (Acomys spp.), a murid rodent that exhibits bona fide regeneration of the back skin and ear pinna, as a model to study heart repair. By comparing them to ordinary mice (Mus musculus), we show that the acute injury response in spiny mice is similar, but with an associated tolerance to infarction through superior survivability, improved ventricular conduction, and near-absence of pathological remodeling. Critically, spiny mice display increased vascularization, altered scar organization, and a more immature phenotype of cardiomyocytes, with a corresponding improvement in heart function. These findings present new avenues for mammalian heart research by leveraging unique tissue properties of the spiny mouse.
format	article
author	Tim Koopmans Henriette van Beijnum Elke F. Roovers Antonio Tomasso Divyanshu Malhotra Jochem Boeter Olympia E. Psathaki Danielle Versteeg Eva van Rooij Kerstin Bartscherer
author_facet	Tim Koopmans Henriette van Beijnum Elke F. Roovers Antonio Tomasso Divyanshu Malhotra Jochem Boeter Olympia E. Psathaki Danielle Versteeg Eva van Rooij Kerstin Bartscherer
author_sort	Tim Koopmans
title	Ischemic tolerance and cardiac repair in the spiny mouse (Acomys)
title_short	Ischemic tolerance and cardiac repair in the spiny mouse (Acomys)
title_full	Ischemic tolerance and cardiac repair in the spiny mouse (Acomys)
title_fullStr	Ischemic tolerance and cardiac repair in the spiny mouse (Acomys)
title_full_unstemmed	Ischemic tolerance and cardiac repair in the spiny mouse (Acomys)
title_sort	ischemic tolerance and cardiac repair in the spiny mouse (acomys)
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/679c838b47c14a9493266eb88940b458
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Ischemic tolerance and cardiac repair in the spiny mouse (Acomys)

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