A Combination of Receptor-Binding Domain and N-Terminal Domain Neutralizing Antibodies Limits the Generation of SARS-CoV-2 Spike Neutralization-Escape Mutants
The U.S. FDA has issued emergency use authorizations (EUAs) for multiple investigational monoclonal antibody (MAb) therapies for the treatment of mild to moderate COVID-19.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
American Society for Microbiology
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/679d11cbba69478ca30bdf9534e81939 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:679d11cbba69478ca30bdf9534e81939 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:679d11cbba69478ca30bdf9534e819392021-11-03T21:52:35ZA Combination of Receptor-Binding Domain and N-Terminal Domain Neutralizing Antibodies Limits the Generation of SARS-CoV-2 Spike Neutralization-Escape Mutants2150-751110.1128/mBio.02473-21https://doaj.org/article/679d11cbba69478ca30bdf9534e819392021-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.02473-21https://doaj.org/toc/2150-7511 The U.S. FDA has issued emergency use authorizations (EUAs) for multiple investigational monoclonal antibody (MAb) therapies for the treatment of mild to moderate COVID-19.Denise HaslwanterM. Eugenia DieterleAnna Z. WecCecilia M. O’BrienMrunal SakharkarCatalina FlorezKaren TongC. Garrett RappazzoGorka LassoOlivia VergnolleAriel S. WirchnianskiRobert H. BortzEthan LaudermilchJ. Maximilian FelsAmanda MengottoRyan J. MalonisGeorge I. GeorgievJose A. QuirozDaniel WrappNianshuang WangKathryn E. DyeJason BarnhillJohn M. DyeJason S. McLellanJohanna P. DailyJonathan R. LaiAndrew S. HerbertLaura M. WalkerKartik ChandranRohit K. JangraAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 5 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Microbiology QR1-502 |
| spellingShingle |
Microbiology QR1-502 Denise Haslwanter M. Eugenia Dieterle Anna Z. Wec Cecilia M. O’Brien Mrunal Sakharkar Catalina Florez Karen Tong C. Garrett Rappazzo Gorka Lasso Olivia Vergnolle Ariel S. Wirchnianski Robert H. Bortz Ethan Laudermilch J. Maximilian Fels Amanda Mengotto Ryan J. Malonis George I. Georgiev Jose A. Quiroz Daniel Wrapp Nianshuang Wang Kathryn E. Dye Jason Barnhill John M. Dye Jason S. McLellan Johanna P. Daily Jonathan R. Lai Andrew S. Herbert Laura M. Walker Kartik Chandran Rohit K. Jangra A Combination of Receptor-Binding Domain and N-Terminal Domain Neutralizing Antibodies Limits the Generation of SARS-CoV-2 Spike Neutralization-Escape Mutants |
| description |
The U.S. FDA has issued emergency use authorizations (EUAs) for multiple investigational monoclonal antibody (MAb) therapies for the treatment of mild to moderate COVID-19. |
| format |
article |
| author |
Denise Haslwanter M. Eugenia Dieterle Anna Z. Wec Cecilia M. O’Brien Mrunal Sakharkar Catalina Florez Karen Tong C. Garrett Rappazzo Gorka Lasso Olivia Vergnolle Ariel S. Wirchnianski Robert H. Bortz Ethan Laudermilch J. Maximilian Fels Amanda Mengotto Ryan J. Malonis George I. Georgiev Jose A. Quiroz Daniel Wrapp Nianshuang Wang Kathryn E. Dye Jason Barnhill John M. Dye Jason S. McLellan Johanna P. Daily Jonathan R. Lai Andrew S. Herbert Laura M. Walker Kartik Chandran Rohit K. Jangra |
| author_facet |
Denise Haslwanter M. Eugenia Dieterle Anna Z. Wec Cecilia M. O’Brien Mrunal Sakharkar Catalina Florez Karen Tong C. Garrett Rappazzo Gorka Lasso Olivia Vergnolle Ariel S. Wirchnianski Robert H. Bortz Ethan Laudermilch J. Maximilian Fels Amanda Mengotto Ryan J. Malonis George I. Georgiev Jose A. Quiroz Daniel Wrapp Nianshuang Wang Kathryn E. Dye Jason Barnhill John M. Dye Jason S. McLellan Johanna P. Daily Jonathan R. Lai Andrew S. Herbert Laura M. Walker Kartik Chandran Rohit K. Jangra |
| author_sort |
Denise Haslwanter |
| title |
A Combination of Receptor-Binding Domain and N-Terminal Domain Neutralizing Antibodies Limits the Generation of SARS-CoV-2 Spike Neutralization-Escape Mutants |
| title_short |
A Combination of Receptor-Binding Domain and N-Terminal Domain Neutralizing Antibodies Limits the Generation of SARS-CoV-2 Spike Neutralization-Escape Mutants |
| title_full |
A Combination of Receptor-Binding Domain and N-Terminal Domain Neutralizing Antibodies Limits the Generation of SARS-CoV-2 Spike Neutralization-Escape Mutants |
| title_fullStr |
A Combination of Receptor-Binding Domain and N-Terminal Domain Neutralizing Antibodies Limits the Generation of SARS-CoV-2 Spike Neutralization-Escape Mutants |
| title_full_unstemmed |
A Combination of Receptor-Binding Domain and N-Terminal Domain Neutralizing Antibodies Limits the Generation of SARS-CoV-2 Spike Neutralization-Escape Mutants |
| title_sort |
combination of receptor-binding domain and n-terminal domain neutralizing antibodies limits the generation of sars-cov-2 spike neutralization-escape mutants |
| publisher |
American Society for Microbiology |
| publishDate |
2021 |
| url |
https://doaj.org/article/679d11cbba69478ca30bdf9534e81939 |
| work_keys_str_mv |
AT denisehaslwanter acombinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT meugeniadieterle acombinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT annazwec acombinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT ceciliamobrien acombinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT mrunalsakharkar acombinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT catalinaflorez acombinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT karentong acombinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT cgarrettrappazzo acombinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT gorkalasso acombinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT oliviavergnolle acombinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT arielswirchnianski acombinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT roberthbortz acombinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT ethanlaudermilch acombinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT jmaximilianfels acombinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT amandamengotto acombinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT ryanjmalonis acombinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT georgeigeorgiev acombinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT joseaquiroz acombinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT danielwrapp acombinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT nianshuangwang acombinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT kathrynedye acombinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT jasonbarnhill acombinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT johnmdye acombinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT jasonsmclellan acombinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT johannapdaily acombinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT jonathanrlai acombinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT andrewsherbert acombinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT lauramwalker acombinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT kartikchandran acombinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT rohitkjangra acombinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT denisehaslwanter combinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT meugeniadieterle combinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT annazwec combinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT ceciliamobrien combinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT mrunalsakharkar combinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT catalinaflorez combinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT karentong combinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT cgarrettrappazzo combinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT gorkalasso combinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT oliviavergnolle combinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT arielswirchnianski combinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT roberthbortz combinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT ethanlaudermilch combinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT jmaximilianfels combinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT amandamengotto combinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT ryanjmalonis combinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT georgeigeorgiev combinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT joseaquiroz combinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT danielwrapp combinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT nianshuangwang combinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT kathrynedye combinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT jasonbarnhill combinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT johnmdye combinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT jasonsmclellan combinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT johannapdaily combinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT jonathanrlai combinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT andrewsherbert combinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT lauramwalker combinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT kartikchandran combinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants AT rohitkjangra combinationofreceptorbindingdomainandnterminaldomainneutralizingantibodieslimitsthegenerationofsarscov2spikeneutralizationescapemutants |
| _version_ |
1718445400774410240 |