Total synthesis of feglymycin based on a linear/convergent hybrid approach using micro-flow amide bond formation

Feglymycin is a biologically active peptide but a challenging synthetic target due to the highly racemizable nature of the 3,5-dihydroxyphenylglycine groups. Here the authors report the synthesis of feglymycin using a microflow system, allowing amide bond formation without severe racemization.

Guardado en:

Detalles Bibliográficos
Autores principales:	Shinichiro Fuse, Yuto Mifune, Hiroyuki Nakamura, Hiroshi Tanaka
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/679d1a768fbf4460b162ac2e3cb129c5
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:679d1a768fbf4460b162ac2e3cb129c5
record_format	dspace
spelling	oai:doaj.org-article:679d1a768fbf4460b162ac2e3cb129c52021-12-02T16:57:50ZTotal synthesis of feglymycin based on a linear/convergent hybrid approach using micro-flow amide bond formation10.1038/ncomms134912041-1723https://doaj.org/article/679d1a768fbf4460b162ac2e3cb129c52016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13491https://doaj.org/toc/2041-1723Feglymycin is a biologically active peptide but a challenging synthetic target due to the highly racemizable nature of the 3,5-dihydroxyphenylglycine groups. Here the authors report the synthesis of feglymycin using a microflow system, allowing amide bond formation without severe racemization.Shinichiro FuseYuto MifuneHiroyuki NakamuraHiroshi TanakaNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shinichiro Fuse Yuto Mifune Hiroyuki Nakamura Hiroshi Tanaka Total synthesis of feglymycin based on a linear/convergent hybrid approach using micro-flow amide bond formation
description	Feglymycin is a biologically active peptide but a challenging synthetic target due to the highly racemizable nature of the 3,5-dihydroxyphenylglycine groups. Here the authors report the synthesis of feglymycin using a microflow system, allowing amide bond formation without severe racemization.
format	article
author	Shinichiro Fuse Yuto Mifune Hiroyuki Nakamura Hiroshi Tanaka
author_facet	Shinichiro Fuse Yuto Mifune Hiroyuki Nakamura Hiroshi Tanaka
author_sort	Shinichiro Fuse
title	Total synthesis of feglymycin based on a linear/convergent hybrid approach using micro-flow amide bond formation
title_short	Total synthesis of feglymycin based on a linear/convergent hybrid approach using micro-flow amide bond formation
title_full	Total synthesis of feglymycin based on a linear/convergent hybrid approach using micro-flow amide bond formation
title_fullStr	Total synthesis of feglymycin based on a linear/convergent hybrid approach using micro-flow amide bond formation
title_full_unstemmed	Total synthesis of feglymycin based on a linear/convergent hybrid approach using micro-flow amide bond formation
title_sort	total synthesis of feglymycin based on a linear/convergent hybrid approach using micro-flow amide bond formation
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/679d1a768fbf4460b162ac2e3cb129c5
work_keys_str_mv	AT shinichirofuse totalsynthesisoffeglymycinbasedonalinearconvergenthybridapproachusingmicroflowamidebondformation AT yutomifune totalsynthesisoffeglymycinbasedonalinearconvergenthybridapproachusingmicroflowamidebondformation AT hiroyukinakamura totalsynthesisoffeglymycinbasedonalinearconvergenthybridapproachusingmicroflowamidebondformation AT hiroshitanaka totalsynthesisoffeglymycinbasedonalinearconvergenthybridapproachusingmicroflowamidebondformation
_version_	1718382449109499904

Total synthesis of feglymycin based on a linear/convergent hybrid approach using micro-flow amide bond formation

Ejemplares similares