Paired associative stimulation of the auditory system: a proof-of-principle study.

<h4>Background</h4>Paired associative stimulation (PAS) consisting of repeated application of transcranial magnetic stimulation (TMS) pulses and contingent exteroceptive stimuli has been shown to induce neuroplastic effects in the motor and somatosensory system. The objective was to inve...

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Autores principales:	Martin Schecklmann, Gregor Volberg, Gabriele Frank, Julia Hadersdorfer, Thomas Steffens, Nathan Weisz, Michael Landgrebe, Göran Hajak, Mark Greenlee, Joseph Classen, Berthold Langguth
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2011
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/679e12bcd2634c6d9f237e471b478a99
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spelling	oai:doaj.org-article:679e12bcd2634c6d9f237e471b478a992021-11-18T07:35:08ZPaired associative stimulation of the auditory system: a proof-of-principle study.1932-620310.1371/journal.pone.0027088https://doaj.org/article/679e12bcd2634c6d9f237e471b478a992011-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22073259/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Paired associative stimulation (PAS) consisting of repeated application of transcranial magnetic stimulation (TMS) pulses and contingent exteroceptive stimuli has been shown to induce neuroplastic effects in the motor and somatosensory system. The objective was to investigate whether the auditory system can be modulated by PAS.<h4>Methods</h4>Acoustic stimuli (4 kHz) were paired with TMS of the auditory cortex with intervals of either 45 ms (PAS(45 ms)) or 10 ms (PAS(10 ms)). Two-hundred paired stimuli were applied at 0.1 Hz and effects were compared with low frequency repetitive TMS (rTMS) at 0.1 Hz (200 stimuli) and 1 Hz (1000 stimuli) in eleven healthy students. Auditory cortex excitability was measured before and after the interventions by long latency auditory evoked potentials (AEPs) for the tone (4 kHz) used in the pairing, and a control tone (1 kHz) in a within subjects design.<h4>Results</h4>Amplitudes of the N1-P2 complex were reduced for the 4 kHz tone after both PAS(45 ms) and PAS(10 ms), but not after the 0.1 Hz and 1 Hz rTMS protocols with more pronounced effects for PAS(45 ms). Similar, but less pronounced effects were observed for the 1 kHz control tone.<h4>Conclusion</h4>These findings indicate that paired associative stimulation may induce tonotopically specific and also tone unspecific human auditory cortex plasticity.Martin SchecklmannGregor VolbergGabriele FrankJulia HadersdorferThomas SteffensNathan WeiszMichael LandgrebeGöran HajakMark GreenleeJoseph ClassenBerthold LangguthPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 11, p e27088 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Martin Schecklmann Gregor Volberg Gabriele Frank Julia Hadersdorfer Thomas Steffens Nathan Weisz Michael Landgrebe Göran Hajak Mark Greenlee Joseph Classen Berthold Langguth Paired associative stimulation of the auditory system: a proof-of-principle study.
description	<h4>Background</h4>Paired associative stimulation (PAS) consisting of repeated application of transcranial magnetic stimulation (TMS) pulses and contingent exteroceptive stimuli has been shown to induce neuroplastic effects in the motor and somatosensory system. The objective was to investigate whether the auditory system can be modulated by PAS.<h4>Methods</h4>Acoustic stimuli (4 kHz) were paired with TMS of the auditory cortex with intervals of either 45 ms (PAS(45 ms)) or 10 ms (PAS(10 ms)). Two-hundred paired stimuli were applied at 0.1 Hz and effects were compared with low frequency repetitive TMS (rTMS) at 0.1 Hz (200 stimuli) and 1 Hz (1000 stimuli) in eleven healthy students. Auditory cortex excitability was measured before and after the interventions by long latency auditory evoked potentials (AEPs) for the tone (4 kHz) used in the pairing, and a control tone (1 kHz) in a within subjects design.<h4>Results</h4>Amplitudes of the N1-P2 complex were reduced for the 4 kHz tone after both PAS(45 ms) and PAS(10 ms), but not after the 0.1 Hz and 1 Hz rTMS protocols with more pronounced effects for PAS(45 ms). Similar, but less pronounced effects were observed for the 1 kHz control tone.<h4>Conclusion</h4>These findings indicate that paired associative stimulation may induce tonotopically specific and also tone unspecific human auditory cortex plasticity.
format	article
author	Martin Schecklmann Gregor Volberg Gabriele Frank Julia Hadersdorfer Thomas Steffens Nathan Weisz Michael Landgrebe Göran Hajak Mark Greenlee Joseph Classen Berthold Langguth
author_facet	Martin Schecklmann Gregor Volberg Gabriele Frank Julia Hadersdorfer Thomas Steffens Nathan Weisz Michael Landgrebe Göran Hajak Mark Greenlee Joseph Classen Berthold Langguth
author_sort	Martin Schecklmann
title	Paired associative stimulation of the auditory system: a proof-of-principle study.
title_short	Paired associative stimulation of the auditory system: a proof-of-principle study.
title_full	Paired associative stimulation of the auditory system: a proof-of-principle study.
title_fullStr	Paired associative stimulation of the auditory system: a proof-of-principle study.
title_full_unstemmed	Paired associative stimulation of the auditory system: a proof-of-principle study.
title_sort	paired associative stimulation of the auditory system: a proof-of-principle study.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/679e12bcd2634c6d9f237e471b478a99
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Paired associative stimulation of the auditory system: a proof-of-principle study.

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