Effects of different models of sucrose intake on the oxidative status of the uterus and ovary of rats.

The aim of the study was to assess the effect of different models of sucrose intake on carbohydrate-lipid metabolism and changes in oxidant balance in the ovaries and uterus of rats. Animals were divided into three groups: I-basic feed, II-feed contains 8% of sucrose, III-alternately every second we...

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Autores principales:	Joanna Sadowska, Wioleta Dudzińska, Izabela Dziaduch
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/67a0ea72dd17462e9dfb47bd6448e8b8
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spelling	oai:doaj.org-article:67a0ea72dd17462e9dfb47bd6448e8b82021-11-25T06:19:09ZEffects of different models of sucrose intake on the oxidative status of the uterus and ovary of rats.1932-620310.1371/journal.pone.0251789https://doaj.org/article/67a0ea72dd17462e9dfb47bd6448e8b82021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0251789https://doaj.org/toc/1932-6203The aim of the study was to assess the effect of different models of sucrose intake on carbohydrate-lipid metabolism and changes in oxidant balance in the ovaries and uterus of rats. Animals were divided into three groups: I-basic feed, II-feed contains 8% of sucrose, III-alternately every second week the basic feed and modified feed contains 16% of sucrose. The diet containing 8% of sucrose was found to result in an increased activity of antioxidant enzymes in the blood, with unchanged malonylodialdehyde concentration. Variable sucrose administration pattern intensified oxidative stress in the blood and led to disturbed redox equilibrium in the rat uterus, even at a comparable long-term sucrose uptake as in the group II. This was manifested as a reduced superoxide dismutase activity (in the blood and uterus) and a higher malonylodialdehyde concentration (in the uterus). The changes observed could have been a result of metabolic disorders (higher amount of visceral fat, higher glucose concentration, higher index of homeostasis model assessment of insulin resistance, and reduced HDL-cholesterol concentration) and endocrine disorders (higher oestrogen concentrations). Changes in the antioxidant status in the rats kept on the alternating diet, may underpin the failure of fertilised egg implantation in the uterine tissue and pregnancy completion.Joanna SadowskaWioleta DudzińskaIzabela DziaduchPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 5, p e0251789 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Joanna Sadowska Wioleta Dudzińska Izabela Dziaduch Effects of different models of sucrose intake on the oxidative status of the uterus and ovary of rats.
description	The aim of the study was to assess the effect of different models of sucrose intake on carbohydrate-lipid metabolism and changes in oxidant balance in the ovaries and uterus of rats. Animals were divided into three groups: I-basic feed, II-feed contains 8% of sucrose, III-alternately every second week the basic feed and modified feed contains 16% of sucrose. The diet containing 8% of sucrose was found to result in an increased activity of antioxidant enzymes in the blood, with unchanged malonylodialdehyde concentration. Variable sucrose administration pattern intensified oxidative stress in the blood and led to disturbed redox equilibrium in the rat uterus, even at a comparable long-term sucrose uptake as in the group II. This was manifested as a reduced superoxide dismutase activity (in the blood and uterus) and a higher malonylodialdehyde concentration (in the uterus). The changes observed could have been a result of metabolic disorders (higher amount of visceral fat, higher glucose concentration, higher index of homeostasis model assessment of insulin resistance, and reduced HDL-cholesterol concentration) and endocrine disorders (higher oestrogen concentrations). Changes in the antioxidant status in the rats kept on the alternating diet, may underpin the failure of fertilised egg implantation in the uterine tissue and pregnancy completion.
format	article
author	Joanna Sadowska Wioleta Dudzińska Izabela Dziaduch
author_facet	Joanna Sadowska Wioleta Dudzińska Izabela Dziaduch
author_sort	Joanna Sadowska
title	Effects of different models of sucrose intake on the oxidative status of the uterus and ovary of rats.
title_short	Effects of different models of sucrose intake on the oxidative status of the uterus and ovary of rats.
title_full	Effects of different models of sucrose intake on the oxidative status of the uterus and ovary of rats.
title_fullStr	Effects of different models of sucrose intake on the oxidative status of the uterus and ovary of rats.
title_full_unstemmed	Effects of different models of sucrose intake on the oxidative status of the uterus and ovary of rats.
title_sort	effects of different models of sucrose intake on the oxidative status of the uterus and ovary of rats.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/67a0ea72dd17462e9dfb47bd6448e8b8
work_keys_str_mv	AT joannasadowska effectsofdifferentmodelsofsucroseintakeontheoxidativestatusoftheuterusandovaryofrats AT wioletadudzinska effectsofdifferentmodelsofsucroseintakeontheoxidativestatusoftheuterusandovaryofrats AT izabeladziaduch effectsofdifferentmodelsofsucroseintakeontheoxidativestatusoftheuterusandovaryofrats
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Effects of different models of sucrose intake on the oxidative status of the uterus and ovary of rats.

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