Genetic circuit characterization by inferring RNA polymerase movement and ribosome usage

Debugging a genetic circuit is frustrated by the inability to characterize parts in the context of the circuit. Here the authors use RNA-seq and ribosome profiling to take ‘snapshots’ of a large circuit in different states.

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Autores principales: Amin Espah Borujeni, Jing Zhang, Hamid Doosthosseini, Alec A. K. Nielsen, Christopher A. Voigt
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
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Acceso en línea:https://doaj.org/article/67a63b86a841423c9a18630376a49a5c
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spelling oai:doaj.org-article:67a63b86a841423c9a18630376a49a5c2021-12-02T18:07:54ZGenetic circuit characterization by inferring RNA polymerase movement and ribosome usage10.1038/s41467-020-18630-22041-1723https://doaj.org/article/67a63b86a841423c9a18630376a49a5c2020-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-18630-2https://doaj.org/toc/2041-1723Debugging a genetic circuit is frustrated by the inability to characterize parts in the context of the circuit. Here the authors use RNA-seq and ribosome profiling to take ‘snapshots’ of a large circuit in different states.Amin Espah BorujeniJing ZhangHamid DoosthosseiniAlec A. K. NielsenChristopher A. VoigtNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Amin Espah Borujeni
Jing Zhang
Hamid Doosthosseini
Alec A. K. Nielsen
Christopher A. Voigt
Genetic circuit characterization by inferring RNA polymerase movement and ribosome usage
description Debugging a genetic circuit is frustrated by the inability to characterize parts in the context of the circuit. Here the authors use RNA-seq and ribosome profiling to take ‘snapshots’ of a large circuit in different states.
format article
author Amin Espah Borujeni
Jing Zhang
Hamid Doosthosseini
Alec A. K. Nielsen
Christopher A. Voigt
author_facet Amin Espah Borujeni
Jing Zhang
Hamid Doosthosseini
Alec A. K. Nielsen
Christopher A. Voigt
author_sort Amin Espah Borujeni
title Genetic circuit characterization by inferring RNA polymerase movement and ribosome usage
title_short Genetic circuit characterization by inferring RNA polymerase movement and ribosome usage
title_full Genetic circuit characterization by inferring RNA polymerase movement and ribosome usage
title_fullStr Genetic circuit characterization by inferring RNA polymerase movement and ribosome usage
title_full_unstemmed Genetic circuit characterization by inferring RNA polymerase movement and ribosome usage
title_sort genetic circuit characterization by inferring rna polymerase movement and ribosome usage
publisher Nature Portfolio
publishDate 2020
url https://doaj.org/article/67a63b86a841423c9a18630376a49a5c
work_keys_str_mv AT aminespahborujeni geneticcircuitcharacterizationbyinferringrnapolymerasemovementandribosomeusage
AT jingzhang geneticcircuitcharacterizationbyinferringrnapolymerasemovementandribosomeusage
AT hamiddoosthosseini geneticcircuitcharacterizationbyinferringrnapolymerasemovementandribosomeusage
AT alecaknielsen geneticcircuitcharacterizationbyinferringrnapolymerasemovementandribosomeusage
AT christopheravoigt geneticcircuitcharacterizationbyinferringrnapolymerasemovementandribosomeusage
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