Single-cell transcriptomic analysis of bloodstream Trypanosoma brucei reconstructs cell cycle progression and developmental quorum sensing

Trypanosoma brucei undergoes developmental steps during host infection. Here, using oligopeptide-induced differentiation in vitro, authors model replicative ‘slender’ to transmissible ‘stumpy’ bloodstream forms and identify developmental and cell cycle regulators by single cell transcriptomics....

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Autores principales:	Emma M. Briggs, Federico Rojas, Richard McCulloch, Keith R. Matthews, Thomas D. Otto
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/67a99b605cd74f13ac7108641227f1f1
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spelling	oai:doaj.org-article:67a99b605cd74f13ac7108641227f1f12021-12-02T14:55:15ZSingle-cell transcriptomic analysis of bloodstream Trypanosoma brucei reconstructs cell cycle progression and developmental quorum sensing10.1038/s41467-021-25607-22041-1723https://doaj.org/article/67a99b605cd74f13ac7108641227f1f12021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25607-2https://doaj.org/toc/2041-1723Trypanosoma brucei undergoes developmental steps during host infection. Here, using oligopeptide-induced differentiation in vitro, authors model replicative ‘slender’ to transmissible ‘stumpy’ bloodstream forms and identify developmental and cell cycle regulators by single cell transcriptomics.Emma M. BriggsFederico RojasRichard McCullochKeith R. MatthewsThomas D. OttoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Emma M. Briggs Federico Rojas Richard McCulloch Keith R. Matthews Thomas D. Otto Single-cell transcriptomic analysis of bloodstream Trypanosoma brucei reconstructs cell cycle progression and developmental quorum sensing
description	Trypanosoma brucei undergoes developmental steps during host infection. Here, using oligopeptide-induced differentiation in vitro, authors model replicative ‘slender’ to transmissible ‘stumpy’ bloodstream forms and identify developmental and cell cycle regulators by single cell transcriptomics.
format	article
author	Emma M. Briggs Federico Rojas Richard McCulloch Keith R. Matthews Thomas D. Otto
author_facet	Emma M. Briggs Federico Rojas Richard McCulloch Keith R. Matthews Thomas D. Otto
author_sort	Emma M. Briggs
title	Single-cell transcriptomic analysis of bloodstream Trypanosoma brucei reconstructs cell cycle progression and developmental quorum sensing
title_short	Single-cell transcriptomic analysis of bloodstream Trypanosoma brucei reconstructs cell cycle progression and developmental quorum sensing
title_full	Single-cell transcriptomic analysis of bloodstream Trypanosoma brucei reconstructs cell cycle progression and developmental quorum sensing
title_fullStr	Single-cell transcriptomic analysis of bloodstream Trypanosoma brucei reconstructs cell cycle progression and developmental quorum sensing
title_full_unstemmed	Single-cell transcriptomic analysis of bloodstream Trypanosoma brucei reconstructs cell cycle progression and developmental quorum sensing
title_sort	single-cell transcriptomic analysis of bloodstream trypanosoma brucei reconstructs cell cycle progression and developmental quorum sensing
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/67a99b605cd74f13ac7108641227f1f1
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Single-cell transcriptomic analysis of bloodstream Trypanosoma brucei reconstructs cell cycle progression and developmental quorum sensing

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