Effect of Obstructive Sleep Apnea on Immunity in Cases of Chronic Rhinosinusitis With Nasal Polyps

Objectives. Chronic rhinosinusitis with nasal polyps (CRSwNP) is a more severe inflammatory form of CRS that often coexists with obstructive sleep apnea (OSA). However, little is known about the relationship between OSA and the immune profile in patients with CRSwNP. We aimed to investigate the immu...

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Autores principales:	Dong-Kyu Kim, Byeong Chan Lee, Ki Joon Park, Gil Myeong Son
Formato:	article
Lenguaje:	EN
Publicado:	Korean Society of Otorhinolaryngology-Head and Neck Surgery 2021
Materias:	eosinophils nasal polyps rhinitis sinusitis sleep sleep apnea syndromes Medicine R Otorhinolaryngology RF1-547
Acceso en línea:	https://doaj.org/article/67b6fe8c79f24b0ca35777bcc1faa9a7
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spelling	oai:doaj.org-article:67b6fe8c79f24b0ca35777bcc1faa9a72021-11-18T02:29:22ZEffect of Obstructive Sleep Apnea on Immunity in Cases of Chronic Rhinosinusitis With Nasal Polyps1976-87102005-072010.21053/ceo.2020.02250https://doaj.org/article/67b6fe8c79f24b0ca35777bcc1faa9a72021-11-01T00:00:00Zhttp://www.e-ceo.org/upload/pdf/ceo-2020-02250.pdfhttps://doaj.org/toc/1976-8710https://doaj.org/toc/2005-0720Objectives. Chronic rhinosinusitis with nasal polyps (CRSwNP) is a more severe inflammatory form of CRS that often coexists with obstructive sleep apnea (OSA). However, little is known about the relationship between OSA and the immune profile in patients with CRSwNP. We aimed to investigate the immune profile of patients with CRSwNP according to OSA severity. Methods. This study included 63 patients with CRSwNP and nine control subjects. Protein levels of inflammatory mediators were determined using multiplex immunoassays. All patients underwent standard polysomnography. Results. In patients with eosinophilic CRSwNP (ECRSwNP), interleukin (IL)-6 and chemokine [C-X-C motif] ligand (CXCL)-1 (type 1 immune-related markers) were upregulated in cases of moderate-to-severe OSA. Additionally, IL-4, IL-13, C-C motif chemokine (CCL)-11, CCL-24 (type 2 immune-related markers), and IL-17A (a type 3 immune-related marker) were present at elevated levels in patients with moderate-to-severe OSA. Although there were no significant differences in type 1, 2, or 3 immune-related markers among patients with non-eosinophilic CRSwNP (NECRSwNP) according to the severity of OSA, transforming growth factor-beta expression was higher in those with moderate-to-severe OSA. Furthermore, in ECRSwNP with moderate-to-severe OSA, associations were detected between serum markers and some upregulated inflammatory markers. Conclusion. OSA may increase the heterogeneity of the immune profile (types 1, 2, and 3) in patients with ECRSwNP, but not in those with NECRSwNP.Dong-Kyu KimByeong Chan LeeKi Joon ParkGil Myeong SonKorean Society of Otorhinolaryngology-Head and Neck Surgeryarticleeosinophilsnasal polypsrhinitissinusitissleepsleep apnea syndromesMedicineROtorhinolaryngologyRF1-547ENClinical and Experimental Otorhinolaryngology, Vol 14, Iss 4, Pp 390-398 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	eosinophils nasal polyps rhinitis sinusitis sleep sleep apnea syndromes Medicine R Otorhinolaryngology RF1-547
spellingShingle	eosinophils nasal polyps rhinitis sinusitis sleep sleep apnea syndromes Medicine R Otorhinolaryngology RF1-547 Dong-Kyu Kim Byeong Chan Lee Ki Joon Park Gil Myeong Son Effect of Obstructive Sleep Apnea on Immunity in Cases of Chronic Rhinosinusitis With Nasal Polyps
description	Objectives. Chronic rhinosinusitis with nasal polyps (CRSwNP) is a more severe inflammatory form of CRS that often coexists with obstructive sleep apnea (OSA). However, little is known about the relationship between OSA and the immune profile in patients with CRSwNP. We aimed to investigate the immune profile of patients with CRSwNP according to OSA severity. Methods. This study included 63 patients with CRSwNP and nine control subjects. Protein levels of inflammatory mediators were determined using multiplex immunoassays. All patients underwent standard polysomnography. Results. In patients with eosinophilic CRSwNP (ECRSwNP), interleukin (IL)-6 and chemokine [C-X-C motif] ligand (CXCL)-1 (type 1 immune-related markers) were upregulated in cases of moderate-to-severe OSA. Additionally, IL-4, IL-13, C-C motif chemokine (CCL)-11, CCL-24 (type 2 immune-related markers), and IL-17A (a type 3 immune-related marker) were present at elevated levels in patients with moderate-to-severe OSA. Although there were no significant differences in type 1, 2, or 3 immune-related markers among patients with non-eosinophilic CRSwNP (NECRSwNP) according to the severity of OSA, transforming growth factor-beta expression was higher in those with moderate-to-severe OSA. Furthermore, in ECRSwNP with moderate-to-severe OSA, associations were detected between serum markers and some upregulated inflammatory markers. Conclusion. OSA may increase the heterogeneity of the immune profile (types 1, 2, and 3) in patients with ECRSwNP, but not in those with NECRSwNP.
format	article
author	Dong-Kyu Kim Byeong Chan Lee Ki Joon Park Gil Myeong Son
author_facet	Dong-Kyu Kim Byeong Chan Lee Ki Joon Park Gil Myeong Son
author_sort	Dong-Kyu Kim
title	Effect of Obstructive Sleep Apnea on Immunity in Cases of Chronic Rhinosinusitis With Nasal Polyps
title_short	Effect of Obstructive Sleep Apnea on Immunity in Cases of Chronic Rhinosinusitis With Nasal Polyps
title_full	Effect of Obstructive Sleep Apnea on Immunity in Cases of Chronic Rhinosinusitis With Nasal Polyps
title_fullStr	Effect of Obstructive Sleep Apnea on Immunity in Cases of Chronic Rhinosinusitis With Nasal Polyps
title_full_unstemmed	Effect of Obstructive Sleep Apnea on Immunity in Cases of Chronic Rhinosinusitis With Nasal Polyps
title_sort	effect of obstructive sleep apnea on immunity in cases of chronic rhinosinusitis with nasal polyps
publisher	Korean Society of Otorhinolaryngology-Head and Neck Surgery
publishDate	2021
url	https://doaj.org/article/67b6fe8c79f24b0ca35777bcc1faa9a7
work_keys_str_mv	AT dongkyukim effectofobstructivesleepapneaonimmunityincasesofchronicrhinosinusitiswithnasalpolyps AT byeongchanlee effectofobstructivesleepapneaonimmunityincasesofchronicrhinosinusitiswithnasalpolyps AT kijoonpark effectofobstructivesleepapneaonimmunityincasesofchronicrhinosinusitiswithnasalpolyps AT gilmyeongson effectofobstructivesleepapneaonimmunityincasesofchronicrhinosinusitiswithnasalpolyps
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Effect of Obstructive Sleep Apnea on Immunity in Cases of Chronic Rhinosinusitis With Nasal Polyps

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