Evaluation of CD10 Expression and Its Relationship with Gleason Score in Prostatic Adenocarcinoma

BACKGROUND AND OBJECTIVE: CD10 is a zinc-dependent metalloproteinase that is associated with factors influencing the prognosis of some cancers. Prostatic adenocarcinoma is one of the most common cancers in men and Gleason grading is an important factor in its prognosis. The present study was conduct...

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Autores principales:	A Ghasemi, M Jalali Nadoushan, R Sedaghat
Formato:	article
Lenguaje:	EN FA
Publicado:	Babol University of Medical Sciences 2021
Materias:	prostatic adenocarcinoma gleason grading system cd10. Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/67b78cedd00842ebab8f95241a4ee4fc
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id	oai:doaj.org-article:67b78cedd00842ebab8f95241a4ee4fc
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spelling	oai:doaj.org-article:67b78cedd00842ebab8f95241a4ee4fc2021-11-29T07:40:49ZEvaluation of CD10 Expression and Its Relationship with Gleason Score in Prostatic Adenocarcinoma1561-41072251-7170https://doaj.org/article/67b78cedd00842ebab8f95241a4ee4fc2021-03-01T00:00:00Zhttp://jbums.org/article-1-8950-en.htmlhttps://doaj.org/toc/1561-4107https://doaj.org/toc/2251-7170BACKGROUND AND OBJECTIVE: CD10 is a zinc-dependent metalloproteinase that is associated with factors influencing the prognosis of some cancers. Prostatic adenocarcinoma is one of the most common cancers in men and Gleason grading is an important factor in its prognosis. The present study was conducted to investigate the relationship between immunohistochemical expression of CD10 and Gleason score as an indicator of prognosis in prostatic adenocarcinoma. METHODS: In this cross-sectional study, 60 paraffin blocks of prostatic adenocarcinoma samples from patients referred to Shahid Mostafa Khomeini Hospital in Tehran from 2013 to 2017 were immunohistochemically stained according to CD10 marker. Information about Gleason score was obtained by observing stained slides by hematoxylin and eosin staining method. The percentage of CD10 positive tumor cells was determined by primary and secondary Gleason score and the relationship between CD10 expression and Gleason score was evaluated. FINDINGS: The mean age of patients was 71±8.79 years. The percentage of CD10 expression varied from 5% to 62% in different samples. The mean percentages of CD10 expression in tumor cells in primary Gleason scores 2 to 5 were 10.75%, 16.16%, 35.20% and 44%, respectively and in secondary Gleason scores 2 to 5 were 10.38%, 17.08%, 38.19% and 53.5%, respectively (p<0.001). CONCLUSION: According to the results of this study, the immunohistochemical marker CD10 has a variable expression in prostatic adenocarcinoma and its increased expression is associated with an increase in the microscopic Gleason score of tumor as a factor influencing the prognosis.A GhasemiM Jalali NadoushanR SedaghatBabol University of Medical Sciencesarticleprostatic adenocarcinomagleason grading systemcd10.MedicineRMedicine (General)R5-920ENFAMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, Vol 23, Iss 1, Pp 60-64 (2021)
institution	DOAJ
collection	DOAJ
language	EN FA
topic	prostatic adenocarcinoma gleason grading system cd10. Medicine R Medicine (General) R5-920
spellingShingle	prostatic adenocarcinoma gleason grading system cd10. Medicine R Medicine (General) R5-920 A Ghasemi M Jalali Nadoushan R Sedaghat Evaluation of CD10 Expression and Its Relationship with Gleason Score in Prostatic Adenocarcinoma
description	BACKGROUND AND OBJECTIVE: CD10 is a zinc-dependent metalloproteinase that is associated with factors influencing the prognosis of some cancers. Prostatic adenocarcinoma is one of the most common cancers in men and Gleason grading is an important factor in its prognosis. The present study was conducted to investigate the relationship between immunohistochemical expression of CD10 and Gleason score as an indicator of prognosis in prostatic adenocarcinoma. METHODS: In this cross-sectional study, 60 paraffin blocks of prostatic adenocarcinoma samples from patients referred to Shahid Mostafa Khomeini Hospital in Tehran from 2013 to 2017 were immunohistochemically stained according to CD10 marker. Information about Gleason score was obtained by observing stained slides by hematoxylin and eosin staining method. The percentage of CD10 positive tumor cells was determined by primary and secondary Gleason score and the relationship between CD10 expression and Gleason score was evaluated. FINDINGS: The mean age of patients was 71±8.79 years. The percentage of CD10 expression varied from 5% to 62% in different samples. The mean percentages of CD10 expression in tumor cells in primary Gleason scores 2 to 5 were 10.75%, 16.16%, 35.20% and 44%, respectively and in secondary Gleason scores 2 to 5 were 10.38%, 17.08%, 38.19% and 53.5%, respectively (p<0.001). CONCLUSION: According to the results of this study, the immunohistochemical marker CD10 has a variable expression in prostatic adenocarcinoma and its increased expression is associated with an increase in the microscopic Gleason score of tumor as a factor influencing the prognosis.
format	article
author	A Ghasemi M Jalali Nadoushan R Sedaghat
author_facet	A Ghasemi M Jalali Nadoushan R Sedaghat
author_sort	A Ghasemi
title	Evaluation of CD10 Expression and Its Relationship with Gleason Score in Prostatic Adenocarcinoma
title_short	Evaluation of CD10 Expression and Its Relationship with Gleason Score in Prostatic Adenocarcinoma
title_full	Evaluation of CD10 Expression and Its Relationship with Gleason Score in Prostatic Adenocarcinoma
title_fullStr	Evaluation of CD10 Expression and Its Relationship with Gleason Score in Prostatic Adenocarcinoma
title_full_unstemmed	Evaluation of CD10 Expression and Its Relationship with Gleason Score in Prostatic Adenocarcinoma
title_sort	evaluation of cd10 expression and its relationship with gleason score in prostatic adenocarcinoma
publisher	Babol University of Medical Sciences
publishDate	2021
url	https://doaj.org/article/67b78cedd00842ebab8f95241a4ee4fc
work_keys_str_mv	AT aghasemi evaluationofcd10expressionanditsrelationshipwithgleasonscoreinprostaticadenocarcinoma AT mjalalinadoushan evaluationofcd10expressionanditsrelationshipwithgleasonscoreinprostaticadenocarcinoma AT rsedaghat evaluationofcd10expressionanditsrelationshipwithgleasonscoreinprostaticadenocarcinoma
_version_	1718407528439611392

Evaluation of CD10 Expression and Its Relationship with Gleason Score in Prostatic Adenocarcinoma

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