Effect of fasting blood glucose on risk of new‐onset hypertension in rural Chinese population: a 15-year follow-up cohort

Abstract Background The purpose of this study was to examine the correlation between fasting blood glucose and new-onset hypertension and examine any synergistically effect modification with multiple risk factors. Methods We conducted post-hoc analyses of repeated-measures data in the original Dongz...

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Autores principales:	Jing Liu, Nan N. Cheng, Zi Y. Zhou, Yue Zhang, Jie Yang, Li S. Liu, Yun Song, Xiao Huang, Gen F. Tang, Bin Y. Wang, Xian H. Qin, Xi P. Xu, Xiang Q. Kong
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Fasting blood glucose Total cholesterol Hypertension Risk Diseases of the circulatory (Cardiovascular) system RC666-701
Acceso en línea:	https://doaj.org/article/67bbe25d5e504cc9a004f31edfb8cb61
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spelling	oai:doaj.org-article:67bbe25d5e504cc9a004f31edfb8cb612021-11-14T12:07:27ZEffect of fasting blood glucose on risk of new‐onset hypertension in rural Chinese population: a 15-year follow-up cohort10.1186/s12872-021-02336-41471-2261https://doaj.org/article/67bbe25d5e504cc9a004f31edfb8cb612021-11-01T00:00:00Zhttps://doi.org/10.1186/s12872-021-02336-4https://doaj.org/toc/1471-2261Abstract Background The purpose of this study was to examine the correlation between fasting blood glucose and new-onset hypertension and examine any synergistically effect modification with multiple risk factors. Methods We conducted post-hoc analyses of repeated-measures data in the original Dongzhi osteoporosis cohort study. In total, 3985 participants without hypertension aged 25–64 years were included in the current analyses. Generalized estimating equation models were used to assess the relationship between fasting blood glucose and risk of new-onset hypertension after adjusting for pertinent covariates and autocorrelations among siblings. Results 393 men (19.4%) and 398 women (20.3%) without hypertension at the baseline developed hypertension by the end of the study period. Compared to lower baseline fasting blood glucose levels (Q1–Q3: < 5.74 mmol/L; clinical cut points: < 5.6 mmol/L), higher baseline fasting blood glucose levels (Q4: ≥ 5.74 mmol/L; clinical cut points: ≥ 5.6 mmol/L and < 7.0 mmol/L) increased the risk of new-onset hypertension significantly [(OR: 1.54, 95% CI 1.19–1.98, P < 0.001); (OR: 1.38, 95% CI 1.09–1.75, P = 0.008)] in women. Additionally, a stronger significant association was found in women with elevated fasting blood glucose on risk of new-onset of hypertension with higher total cholesterol (≥ 5.2 mmol/L) [(OR: 2.76; 95% CI: (1.54, 4.96), P < 0.001)]. However, no association was found between fasting blood glucose and risk of new-onset hypertension in men. Conclusions High fasting blood glucose may be significantly associated with risk of new-onset hypertension in Chinese women, especially in women with higher total cholesterol. Further randomized studies are needed to confirm our findings.Jing LiuNan N. ChengZi Y. ZhouYue ZhangJie YangLi S. LiuYun SongXiao HuangGen F. TangBin Y. WangXian H. QinXi P. XuXiang Q. KongBMCarticleFasting blood glucoseTotal cholesterolHypertensionRiskDiseases of the circulatory (Cardiovascular) systemRC666-701ENBMC Cardiovascular Disorders, Vol 21, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Fasting blood glucose Total cholesterol Hypertension Risk Diseases of the circulatory (Cardiovascular) system RC666-701
spellingShingle	Fasting blood glucose Total cholesterol Hypertension Risk Diseases of the circulatory (Cardiovascular) system RC666-701 Jing Liu Nan N. Cheng Zi Y. Zhou Yue Zhang Jie Yang Li S. Liu Yun Song Xiao Huang Gen F. Tang Bin Y. Wang Xian H. Qin Xi P. Xu Xiang Q. Kong Effect of fasting blood glucose on risk of new‐onset hypertension in rural Chinese population: a 15-year follow-up cohort
description	Abstract Background The purpose of this study was to examine the correlation between fasting blood glucose and new-onset hypertension and examine any synergistically effect modification with multiple risk factors. Methods We conducted post-hoc analyses of repeated-measures data in the original Dongzhi osteoporosis cohort study. In total, 3985 participants without hypertension aged 25–64 years were included in the current analyses. Generalized estimating equation models were used to assess the relationship between fasting blood glucose and risk of new-onset hypertension after adjusting for pertinent covariates and autocorrelations among siblings. Results 393 men (19.4%) and 398 women (20.3%) without hypertension at the baseline developed hypertension by the end of the study period. Compared to lower baseline fasting blood glucose levels (Q1–Q3: < 5.74 mmol/L; clinical cut points: < 5.6 mmol/L), higher baseline fasting blood glucose levels (Q4: ≥ 5.74 mmol/L; clinical cut points: ≥ 5.6 mmol/L and < 7.0 mmol/L) increased the risk of new-onset hypertension significantly [(OR: 1.54, 95% CI 1.19–1.98, P < 0.001); (OR: 1.38, 95% CI 1.09–1.75, P = 0.008)] in women. Additionally, a stronger significant association was found in women with elevated fasting blood glucose on risk of new-onset of hypertension with higher total cholesterol (≥ 5.2 mmol/L) [(OR: 2.76; 95% CI: (1.54, 4.96), P < 0.001)]. However, no association was found between fasting blood glucose and risk of new-onset hypertension in men. Conclusions High fasting blood glucose may be significantly associated with risk of new-onset hypertension in Chinese women, especially in women with higher total cholesterol. Further randomized studies are needed to confirm our findings.
format	article
author	Jing Liu Nan N. Cheng Zi Y. Zhou Yue Zhang Jie Yang Li S. Liu Yun Song Xiao Huang Gen F. Tang Bin Y. Wang Xian H. Qin Xi P. Xu Xiang Q. Kong
author_facet	Jing Liu Nan N. Cheng Zi Y. Zhou Yue Zhang Jie Yang Li S. Liu Yun Song Xiao Huang Gen F. Tang Bin Y. Wang Xian H. Qin Xi P. Xu Xiang Q. Kong
author_sort	Jing Liu
title	Effect of fasting blood glucose on risk of new‐onset hypertension in rural Chinese population: a 15-year follow-up cohort
title_short	Effect of fasting blood glucose on risk of new‐onset hypertension in rural Chinese population: a 15-year follow-up cohort
title_full	Effect of fasting blood glucose on risk of new‐onset hypertension in rural Chinese population: a 15-year follow-up cohort
title_fullStr	Effect of fasting blood glucose on risk of new‐onset hypertension in rural Chinese population: a 15-year follow-up cohort
title_full_unstemmed	Effect of fasting blood glucose on risk of new‐onset hypertension in rural Chinese population: a 15-year follow-up cohort
title_sort	effect of fasting blood glucose on risk of new‐onset hypertension in rural chinese population: a 15-year follow-up cohort
publisher	BMC
publishDate	2021
url	https://doaj.org/article/67bbe25d5e504cc9a004f31edfb8cb61
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Effect of fasting blood glucose on risk of new‐onset hypertension in rural Chinese population: a 15-year follow-up cohort

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