Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance
Platinum chemotherapy is standard of care in ovarian cancers but treatment resistance commonly develops. Here, the authors show that the extracellular microenvironment is modulated following chemotherapy and the changes in matrix proteins and stiffness alter the cell death response of tumour cells.
Guardado en:
| Autores principales: | , , , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2021
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/67c04582b2c44334b40a53907f9099c4 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:67c04582b2c44334b40a53907f9099c4 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:67c04582b2c44334b40a53907f9099c42021-12-02T17:44:52ZCo-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance10.1038/s41467-021-24009-82041-1723https://doaj.org/article/67c04582b2c44334b40a53907f9099c42021-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24009-8https://doaj.org/toc/2041-1723Platinum chemotherapy is standard of care in ovarian cancers but treatment resistance commonly develops. Here, the authors show that the extracellular microenvironment is modulated following chemotherapy and the changes in matrix proteins and stiffness alter the cell death response of tumour cells.Elina A. PietiläJordi Gonzalez-MolinaLidia Moyano-GalceranSanaz JamalzadehKaiyang ZhangLaura LehtinenS. Pauliina TurunenTomás A. MartinsOkan GultekinTarja LamminenKatja KaipioUlrika JoneborgJohanna HynninenSakari HietanenSeija GrénmanRainer LehtonenSampsa HautaniemiOlli CarpénJoseph W. CarlsonKaisa LehtiNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-19 (2021) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Elina A. Pietilä Jordi Gonzalez-Molina Lidia Moyano-Galceran Sanaz Jamalzadeh Kaiyang Zhang Laura Lehtinen S. Pauliina Turunen Tomás A. Martins Okan Gultekin Tarja Lamminen Katja Kaipio Ulrika Joneborg Johanna Hynninen Sakari Hietanen Seija Grénman Rainer Lehtonen Sampsa Hautaniemi Olli Carpén Joseph W. Carlson Kaisa Lehti Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance |
| description |
Platinum chemotherapy is standard of care in ovarian cancers but treatment resistance commonly develops. Here, the authors show that the extracellular microenvironment is modulated following chemotherapy and the changes in matrix proteins and stiffness alter the cell death response of tumour cells. |
| format |
article |
| author |
Elina A. Pietilä Jordi Gonzalez-Molina Lidia Moyano-Galceran Sanaz Jamalzadeh Kaiyang Zhang Laura Lehtinen S. Pauliina Turunen Tomás A. Martins Okan Gultekin Tarja Lamminen Katja Kaipio Ulrika Joneborg Johanna Hynninen Sakari Hietanen Seija Grénman Rainer Lehtonen Sampsa Hautaniemi Olli Carpén Joseph W. Carlson Kaisa Lehti |
| author_facet |
Elina A. Pietilä Jordi Gonzalez-Molina Lidia Moyano-Galceran Sanaz Jamalzadeh Kaiyang Zhang Laura Lehtinen S. Pauliina Turunen Tomás A. Martins Okan Gultekin Tarja Lamminen Katja Kaipio Ulrika Joneborg Johanna Hynninen Sakari Hietanen Seija Grénman Rainer Lehtonen Sampsa Hautaniemi Olli Carpén Joseph W. Carlson Kaisa Lehti |
| author_sort |
Elina A. Pietilä |
| title |
Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance |
| title_short |
Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance |
| title_full |
Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance |
| title_fullStr |
Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance |
| title_full_unstemmed |
Co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance |
| title_sort |
co-evolution of matrisome and adaptive adhesion dynamics drives ovarian cancer chemoresistance |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/67c04582b2c44334b40a53907f9099c4 |
| work_keys_str_mv |
AT elinaapietila coevolutionofmatrisomeandadaptiveadhesiondynamicsdrivesovariancancerchemoresistance AT jordigonzalezmolina coevolutionofmatrisomeandadaptiveadhesiondynamicsdrivesovariancancerchemoresistance AT lidiamoyanogalceran coevolutionofmatrisomeandadaptiveadhesiondynamicsdrivesovariancancerchemoresistance AT sanazjamalzadeh coevolutionofmatrisomeandadaptiveadhesiondynamicsdrivesovariancancerchemoresistance AT kaiyangzhang coevolutionofmatrisomeandadaptiveadhesiondynamicsdrivesovariancancerchemoresistance AT lauralehtinen coevolutionofmatrisomeandadaptiveadhesiondynamicsdrivesovariancancerchemoresistance AT spauliinaturunen coevolutionofmatrisomeandadaptiveadhesiondynamicsdrivesovariancancerchemoresistance AT tomasamartins coevolutionofmatrisomeandadaptiveadhesiondynamicsdrivesovariancancerchemoresistance AT okangultekin coevolutionofmatrisomeandadaptiveadhesiondynamicsdrivesovariancancerchemoresistance AT tarjalamminen coevolutionofmatrisomeandadaptiveadhesiondynamicsdrivesovariancancerchemoresistance AT katjakaipio coevolutionofmatrisomeandadaptiveadhesiondynamicsdrivesovariancancerchemoresistance AT ulrikajoneborg coevolutionofmatrisomeandadaptiveadhesiondynamicsdrivesovariancancerchemoresistance AT johannahynninen coevolutionofmatrisomeandadaptiveadhesiondynamicsdrivesovariancancerchemoresistance AT sakarihietanen coevolutionofmatrisomeandadaptiveadhesiondynamicsdrivesovariancancerchemoresistance AT seijagrenman coevolutionofmatrisomeandadaptiveadhesiondynamicsdrivesovariancancerchemoresistance AT rainerlehtonen coevolutionofmatrisomeandadaptiveadhesiondynamicsdrivesovariancancerchemoresistance AT sampsahautaniemi coevolutionofmatrisomeandadaptiveadhesiondynamicsdrivesovariancancerchemoresistance AT ollicarpen coevolutionofmatrisomeandadaptiveadhesiondynamicsdrivesovariancancerchemoresistance AT josephwcarlson coevolutionofmatrisomeandadaptiveadhesiondynamicsdrivesovariancancerchemoresistance AT kaisalehti coevolutionofmatrisomeandadaptiveadhesiondynamicsdrivesovariancancerchemoresistance |
| _version_ |
1718379648698548224 |