Analysis of MYO1H Gene Polymorphism in Skeletal Class-III Malocclusion Due to Mandibular Prognathism

Background Mandibular prognathism (MP) is a craniofacial deformity resulting from the combined effects of environmental and genetic factors. Although various linkage and genome-wide association studies for mandibular prognathism have identified multiple strongly associated regions and genes, the cau...

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Autores principales:	Anjana Atteeri, Praveen Kumar Neela, Pavan Kumar Mamillapalli, Vasu M. Sesham, Sreekanth Keesara, Jaya Chandra, Udayini Monica, Vasavi Mohan, Shubhangi Miryala, Fatema A. Khan, Priyanka Makthal
Formato:	article
Lenguaje:	EN
Publicado:	Georg Thieme Verlag KG 2021
Materias:	mandibular prognathism gene myo1h Genetics QH426-470 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/67c15773a1954bcda5583cb1dce14235
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spelling	oai:doaj.org-article:67c15773a1954bcda5583cb1dce142352021-12-01T23:41:03ZAnalysis of MYO1H Gene Polymorphism in Skeletal Class-III Malocclusion Due to Mandibular Prognathism2699-940410.1055/s-0041-1731066https://doaj.org/article/67c15773a1954bcda5583cb1dce142352021-06-01T00:00:00Zhttp://www.thieme-connect.de/DOI/DOI?10.1055/s-0041-1731066https://doaj.org/toc/2699-9404Background Mandibular prognathism (MP) is a craniofacial deformity resulting from the combined effects of environmental and genetic factors. Although various linkage and genome-wide association studies for mandibular prognathism have identified multiple strongly associated regions and genes, the causal genes and variants responsible for the deformity remained ambiguous. Aim This research work was aimed to study the association between polymorphism rs10850110 of the MYO1H gene and skeletal class-III malocclusion in our local population. Materials and Methods Thirty patients with skeletal class III due to mandibular prognathism in the study group and 30 patients with skeletal class I in the control group were selected for this study. These patients were from both sexes and above age 10 years. Based on the cephalometric values, patients were categorized into study and control groups. SNB (angle between sella, nasion and point B at nasion) greater than 82 degrees with an ANB (angle between point A, nasion and point B at nasion) of less than 0 degrees in the study group and ANB (angle between point A, nasion and point B at nasion) of 2 to 4 degrees in the control group were categorized. The polymorphism (rs10850110) of the MYO1H gene was genotyped using polymerase chain reaction and restriction fragment length polymorphism. Associations were tested with SNP exact test using SNPstats software. Results The single-nucleotide polymorphism rs10850110 showed a statistically significant association with mandibular prognathism. The G allele of marker rs10850110 (5′ of myosin1H - MYO1H) was overrepresented when compared with the “A” allele in mandibular prognathism cases (p < 0.0001), and this was very significant. Conclusion These results suggest that the rs10850110 polymorphism of the MYO1H gene is associated with an increased risk for mandibular prognathism.Anjana AtteeriPraveen Kumar NeelaPavan Kumar MamillapalliVasu M. SeshamSreekanth KeesaraJaya ChandraUdayini MonicaVasavi MohanShubhangi MiryalaFatema A. KhanPriyanka MakthalGeorg Thieme Verlag KGarticlemandibular prognathismgene myo1h GeneticsQH426-470Neoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENGlobal Medical Genetics, Vol 08, Iss 04, Pp 156-161 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	mandibular prognathism gene myo1h Genetics QH426-470 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	mandibular prognathism gene myo1h Genetics QH426-470 Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Anjana Atteeri Praveen Kumar Neela Pavan Kumar Mamillapalli Vasu M. Sesham Sreekanth Keesara Jaya Chandra Udayini Monica Vasavi Mohan Shubhangi Miryala Fatema A. Khan Priyanka Makthal Analysis of MYO1H Gene Polymorphism in Skeletal Class-III Malocclusion Due to Mandibular Prognathism
description	Background Mandibular prognathism (MP) is a craniofacial deformity resulting from the combined effects of environmental and genetic factors. Although various linkage and genome-wide association studies for mandibular prognathism have identified multiple strongly associated regions and genes, the causal genes and variants responsible for the deformity remained ambiguous. Aim This research work was aimed to study the association between polymorphism rs10850110 of the MYO1H gene and skeletal class-III malocclusion in our local population. Materials and Methods Thirty patients with skeletal class III due to mandibular prognathism in the study group and 30 patients with skeletal class I in the control group were selected for this study. These patients were from both sexes and above age 10 years. Based on the cephalometric values, patients were categorized into study and control groups. SNB (angle between sella, nasion and point B at nasion) greater than 82 degrees with an ANB (angle between point A, nasion and point B at nasion) of less than 0 degrees in the study group and ANB (angle between point A, nasion and point B at nasion) of 2 to 4 degrees in the control group were categorized. The polymorphism (rs10850110) of the MYO1H gene was genotyped using polymerase chain reaction and restriction fragment length polymorphism. Associations were tested with SNP exact test using SNPstats software. Results The single-nucleotide polymorphism rs10850110 showed a statistically significant association with mandibular prognathism. The G allele of marker rs10850110 (5′ of myosin1H - MYO1H) was overrepresented when compared with the “A” allele in mandibular prognathism cases (p < 0.0001), and this was very significant. Conclusion These results suggest that the rs10850110 polymorphism of the MYO1H gene is associated with an increased risk for mandibular prognathism.
format	article
author	Anjana Atteeri Praveen Kumar Neela Pavan Kumar Mamillapalli Vasu M. Sesham Sreekanth Keesara Jaya Chandra Udayini Monica Vasavi Mohan Shubhangi Miryala Fatema A. Khan Priyanka Makthal
author_facet	Anjana Atteeri Praveen Kumar Neela Pavan Kumar Mamillapalli Vasu M. Sesham Sreekanth Keesara Jaya Chandra Udayini Monica Vasavi Mohan Shubhangi Miryala Fatema A. Khan Priyanka Makthal
author_sort	Anjana Atteeri
title	Analysis of MYO1H Gene Polymorphism in Skeletal Class-III Malocclusion Due to Mandibular Prognathism
title_short	Analysis of MYO1H Gene Polymorphism in Skeletal Class-III Malocclusion Due to Mandibular Prognathism
title_full	Analysis of MYO1H Gene Polymorphism in Skeletal Class-III Malocclusion Due to Mandibular Prognathism
title_fullStr	Analysis of MYO1H Gene Polymorphism in Skeletal Class-III Malocclusion Due to Mandibular Prognathism
title_full_unstemmed	Analysis of MYO1H Gene Polymorphism in Skeletal Class-III Malocclusion Due to Mandibular Prognathism
title_sort	analysis of myo1h gene polymorphism in skeletal class-iii malocclusion due to mandibular prognathism
publisher	Georg Thieme Verlag KG
publishDate	2021
url	https://doaj.org/article/67c15773a1954bcda5583cb1dce14235
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Analysis of MYO1H Gene Polymorphism in Skeletal Class-III Malocclusion Due to Mandibular Prognathism

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