BRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance

BRCA1 mutations located within the BRCT domain result in proteasomal degradation and sensitivity to PARP inhibitors (PARPi). Here, the authors report genetic rearrangements in the BRCA1 gene that generate a BRCT-less BRCA1 protein isoform, which avoids degradation and leads to PARPi resistance.

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Auteurs principaux:	Yifan Wang, Andrea J. Bernhardy, Joseph Nacson, John J. Krais, Yin-Fei Tan, Emmanuelle Nicolas, Marc R. Radke, Elizabeth Handorf, Alba Llop-Guevara, Judith Balmaña, Elizabeth M. Swisher, Violeta Serra, Suraj Peri, Neil Johnson
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2019
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/67c22e7b21e74d119a7920f907472b4a
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spelling	oai:doaj.org-article:67c22e7b21e74d119a7920f907472b4a2021-12-02T14:38:42ZBRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance10.1038/s41467-019-13530-62041-1723https://doaj.org/article/67c22e7b21e74d119a7920f907472b4a2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13530-6https://doaj.org/toc/2041-1723BRCA1 mutations located within the BRCT domain result in proteasomal degradation and sensitivity to PARP inhibitors (PARPi). Here, the authors report genetic rearrangements in the BRCA1 gene that generate a BRCT-less BRCA1 protein isoform, which avoids degradation and leads to PARPi resistance.Yifan WangAndrea J. BernhardyJoseph NacsonJohn J. KraisYin-Fei TanEmmanuelle NicolasMarc R. RadkeElizabeth HandorfAlba Llop-GuevaraJudith BalmañaElizabeth M. SwisherVioleta SerraSuraj PeriNeil JohnsonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Yifan Wang Andrea J. Bernhardy Joseph Nacson John J. Krais Yin-Fei Tan Emmanuelle Nicolas Marc R. Radke Elizabeth Handorf Alba Llop-Guevara Judith Balmaña Elizabeth M. Swisher Violeta Serra Suraj Peri Neil Johnson BRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance
description	BRCA1 mutations located within the BRCT domain result in proteasomal degradation and sensitivity to PARP inhibitors (PARPi). Here, the authors report genetic rearrangements in the BRCA1 gene that generate a BRCT-less BRCA1 protein isoform, which avoids degradation and leads to PARPi resistance.
format	article
author	Yifan Wang Andrea J. Bernhardy Joseph Nacson John J. Krais Yin-Fei Tan Emmanuelle Nicolas Marc R. Radke Elizabeth Handorf Alba Llop-Guevara Judith Balmaña Elizabeth M. Swisher Violeta Serra Suraj Peri Neil Johnson
author_facet	Yifan Wang Andrea J. Bernhardy Joseph Nacson John J. Krais Yin-Fei Tan Emmanuelle Nicolas Marc R. Radke Elizabeth Handorf Alba Llop-Guevara Judith Balmaña Elizabeth M. Swisher Violeta Serra Suraj Peri Neil Johnson
author_sort	Yifan Wang
title	BRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance
title_short	BRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance
title_full	BRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance
title_fullStr	BRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance
title_full_unstemmed	BRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance
title_sort	brca1 intronic alu elements drive gene rearrangements and parp inhibitor resistance
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/67c22e7b21e74d119a7920f907472b4a
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BRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance

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