BRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance

BRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance

BRCA1 mutations located within the BRCT domain result in proteasomal degradation and sensitivity to PARP inhibitors (PARPi). Here, the authors report genetic rearrangements in the BRCA1 gene that generate a BRCT-less BRCA1 protein isoform, which avoids degradation and leads to PARPi resistance.

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Autores principales: Yifan Wang, Andrea J. Bernhardy, Joseph Nacson, John J. Krais, Yin-Fei Tan, Emmanuelle Nicolas, Marc R. Radke, Elizabeth Handorf, Alba Llop-Guevara, Judith Balmaña, Elizabeth M. Swisher, Violeta Serra, Suraj Peri, Neil Johnson
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2019
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Acceso en línea:https://doaj.org/article/67c22e7b21e74d119a7920f907472b4a
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spelling oai:doaj.org-article:67c22e7b21e74d119a7920f907472b4a2021-12-02T14:38:42ZBRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance10.1038/s41467-019-13530-62041-1723https://doaj.org/article/67c22e7b21e74d119a7920f907472b4a2019-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13530-6https://doaj.org/toc/2041-1723BRCA1 mutations located within the BRCT domain result in proteasomal degradation and sensitivity to PARP inhibitors (PARPi). Here, the authors report genetic rearrangements in the BRCA1 gene that generate a BRCT-less BRCA1 protein isoform, which avoids degradation and leads to PARPi resistance.Yifan WangAndrea J. BernhardyJoseph NacsonJohn J. KraisYin-Fei TanEmmanuelle NicolasMarc R. RadkeElizabeth HandorfAlba Llop-GuevaraJudith BalmañaElizabeth M. SwisherVioleta SerraSuraj PeriNeil JohnsonNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yifan Wang
Andrea J. Bernhardy
Joseph Nacson
John J. Krais
Yin-Fei Tan
Emmanuelle Nicolas
Marc R. Radke
Elizabeth Handorf
Alba Llop-Guevara
Judith Balmaña
Elizabeth M. Swisher
Violeta Serra
Suraj Peri
Neil Johnson
BRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance
description BRCA1 mutations located within the BRCT domain result in proteasomal degradation and sensitivity to PARP inhibitors (PARPi). Here, the authors report genetic rearrangements in the BRCA1 gene that generate a BRCT-less BRCA1 protein isoform, which avoids degradation and leads to PARPi resistance.
format article
author Yifan Wang
Andrea J. Bernhardy
Joseph Nacson
John J. Krais
Yin-Fei Tan
Emmanuelle Nicolas
Marc R. Radke
Elizabeth Handorf
Alba Llop-Guevara
Judith Balmaña
Elizabeth M. Swisher
Violeta Serra
Suraj Peri
Neil Johnson
author_facet Yifan Wang
Andrea J. Bernhardy
Joseph Nacson
John J. Krais
Yin-Fei Tan
Emmanuelle Nicolas
Marc R. Radke
Elizabeth Handorf
Alba Llop-Guevara
Judith Balmaña
Elizabeth M. Swisher
Violeta Serra
Suraj Peri
Neil Johnson
author_sort Yifan Wang
title BRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance
title_short BRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance
title_full BRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance
title_fullStr BRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance
title_full_unstemmed BRCA1 intronic Alu elements drive gene rearrangements and PARP inhibitor resistance
title_sort brca1 intronic alu elements drive gene rearrangements and parp inhibitor resistance
publisher Nature Portfolio
publishDate 2019
url https://doaj.org/article/67c22e7b21e74d119a7920f907472b4a
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