Cytokines and neuro-specific proteins in viral encephalitis and convulsive syndrome in children. II. Convulsive syndrome

In this Section we provide new data on the pathogenetic factors in pediatric convulsive syndrome, including a prominent role of viral infection in developing seizures and epilepsy (EPL) in children, as evidenced by clinical and experimental studies. Various forms of convulsive syndrome associated wi...

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Autores principales:	L. A. Alekseeva, G. F. Zheleznikova, E. Y. Gorelik, N. V. Sckripchenko, A. A. Zhirkov
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2021
Materias:	cytokines chemokines neurospecific proteins febrile convulsions epileptic status epilepsy neonatal convulsions fires children Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/67c4c1556ae3479881a99e4065a748f8
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spelling	oai:doaj.org-article:67c4c1556ae3479881a99e4065a748f82021-11-22T07:09:55ZCytokines and neuro-specific proteins in viral encephalitis and convulsive syndrome in children. II. Convulsive syndrome2220-76192313-739810.15789/2220-7619-CAN-1449https://doaj.org/article/67c4c1556ae3479881a99e4065a748f82021-06-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/1449https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398In this Section we provide new data on the pathogenetic factors in pediatric convulsive syndrome, including a prominent role of viral infection in developing seizures and epilepsy (EPL) in children, as evidenced by clinical and experimental studies. Various forms of convulsive syndrome associated with viral infection include febrile convulsions and febrile epileptic status, encephalitis-related acute symptomatic seizures, and postencephalitic epilepsy. The human herpesvirus-6 isolated in temporal lobe epilepsy is a frequent causative agent of febrile seizures and febrile epileptic status. Febrile seizures and, especially, febrile epileptic status are associated with further developing epilepsy. Of special note is the febrile infection-related epileptic syndrome (FIRES) more often affecting school-aged children and characterized by extremely severe course and unfavorable outcome. Convulsive syndrome is associated with systemic inflammation and overproduced pro-inflammatory cytokines that increase permeability of the blood-brain barrier and functional activity of brain-resident cells, which are involved in eliciting seizures and maintaining epileptogenesis. Taking into consideration the key role of inflammation underlying convulsive syndrome, in recent decades cytokines and chemokines have been widely studied as possible prognostic criteria for epileptogenesis. Neuron-specific proteins are examined as markers of brain cell damage in various inflammatory diseases of the central nervous system. The first Section of the review presented current understanding on systemic and local cytokine/chemokine response in viral encephalitis. Here we present clinical trials published within the last 5—7 years assessing cytokines/chemokines and neuron-specific proteins in children with various forms of convulsive syndrome, including epilepsy. Association between biomarker level and disease clinical parameters as well as potential for their use to diagnose and predict its further course are discussed.L. A. AlekseevaG. F. ZheleznikovaE. Y. GorelikN. V. SckripchenkoA. A. ZhirkovSankt-Peterburg : NIIÈM imeni Pasteraarticlecytokineschemokinesneurospecific proteinsfebrile convulsionsepileptic statusepilepsyneonatal convulsionsfireschildrenInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 11, Iss 3, Pp 433-446 (2021)
institution	DOAJ
collection	DOAJ
language	RU
topic	cytokines chemokines neurospecific proteins febrile convulsions epileptic status epilepsy neonatal convulsions fires children Infectious and parasitic diseases RC109-216
spellingShingle	cytokines chemokines neurospecific proteins febrile convulsions epileptic status epilepsy neonatal convulsions fires children Infectious and parasitic diseases RC109-216 L. A. Alekseeva G. F. Zheleznikova E. Y. Gorelik N. V. Sckripchenko A. A. Zhirkov Cytokines and neuro-specific proteins in viral encephalitis and convulsive syndrome in children. II. Convulsive syndrome
description	In this Section we provide new data on the pathogenetic factors in pediatric convulsive syndrome, including a prominent role of viral infection in developing seizures and epilepsy (EPL) in children, as evidenced by clinical and experimental studies. Various forms of convulsive syndrome associated with viral infection include febrile convulsions and febrile epileptic status, encephalitis-related acute symptomatic seizures, and postencephalitic epilepsy. The human herpesvirus-6 isolated in temporal lobe epilepsy is a frequent causative agent of febrile seizures and febrile epileptic status. Febrile seizures and, especially, febrile epileptic status are associated with further developing epilepsy. Of special note is the febrile infection-related epileptic syndrome (FIRES) more often affecting school-aged children and characterized by extremely severe course and unfavorable outcome. Convulsive syndrome is associated with systemic inflammation and overproduced pro-inflammatory cytokines that increase permeability of the blood-brain barrier and functional activity of brain-resident cells, which are involved in eliciting seizures and maintaining epileptogenesis. Taking into consideration the key role of inflammation underlying convulsive syndrome, in recent decades cytokines and chemokines have been widely studied as possible prognostic criteria for epileptogenesis. Neuron-specific proteins are examined as markers of brain cell damage in various inflammatory diseases of the central nervous system. The first Section of the review presented current understanding on systemic and local cytokine/chemokine response in viral encephalitis. Here we present clinical trials published within the last 5—7 years assessing cytokines/chemokines and neuron-specific proteins in children with various forms of convulsive syndrome, including epilepsy. Association between biomarker level and disease clinical parameters as well as potential for their use to diagnose and predict its further course are discussed.
format	article
author	L. A. Alekseeva G. F. Zheleznikova E. Y. Gorelik N. V. Sckripchenko A. A. Zhirkov
author_facet	L. A. Alekseeva G. F. Zheleznikova E. Y. Gorelik N. V. Sckripchenko A. A. Zhirkov
author_sort	L. A. Alekseeva
title	Cytokines and neuro-specific proteins in viral encephalitis and convulsive syndrome in children. II. Convulsive syndrome
title_short	Cytokines and neuro-specific proteins in viral encephalitis and convulsive syndrome in children. II. Convulsive syndrome
title_full	Cytokines and neuro-specific proteins in viral encephalitis and convulsive syndrome in children. II. Convulsive syndrome
title_fullStr	Cytokines and neuro-specific proteins in viral encephalitis and convulsive syndrome in children. II. Convulsive syndrome
title_full_unstemmed	Cytokines and neuro-specific proteins in viral encephalitis and convulsive syndrome in children. II. Convulsive syndrome
title_sort	cytokines and neuro-specific proteins in viral encephalitis and convulsive syndrome in children. ii. convulsive syndrome
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2021
url	https://doaj.org/article/67c4c1556ae3479881a99e4065a748f8
work_keys_str_mv	AT laalekseeva cytokinesandneurospecificproteinsinviralencephalitisandconvulsivesyndromeinchildreniiconvulsivesyndrome AT gfzheleznikova cytokinesandneurospecificproteinsinviralencephalitisandconvulsivesyndromeinchildreniiconvulsivesyndrome AT eygorelik cytokinesandneurospecificproteinsinviralencephalitisandconvulsivesyndromeinchildreniiconvulsivesyndrome AT nvsckripchenko cytokinesandneurospecificproteinsinviralencephalitisandconvulsivesyndromeinchildreniiconvulsivesyndrome AT aazhirkov cytokinesandneurospecificproteinsinviralencephalitisandconvulsivesyndromeinchildreniiconvulsivesyndrome
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Cytokines and neuro-specific proteins in viral encephalitis and convulsive syndrome in children. II. Convulsive syndrome

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