Macrophage VLDLR mediates obesity-induced insulin resistance with adipose tissue inflammation

Macrophage VLDLR mediates obesity-induced insulin resistance with adipose tissue inflammation

VLDLR regulates cellular lipoprotein uptake and storage. Here, the authors show that VLDLR, expressed on adipose tissue macrophages, is upregulated in obesity and promotes adipose tissue inflammation by upregulating ceramide production and facilitating M1-like macrophage polarization.

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Autores principales: Kyung Cheul Shin, Injae Hwang, Sung Sik Choe, Jeu Park, Yul Ji, Jong In Kim, Gha Young Lee, Sung Hee Choi, Jianhong Ching, Jean-Paul Kovalik, Jae Bum Kim
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Q
Acceso en línea:https://doaj.org/article/67c72e112e95430fb6d3dc4e4e0e79d3
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spelling oai:doaj.org-article:67c72e112e95430fb6d3dc4e4e0e79d32021-12-02T15:37:03ZMacrophage VLDLR mediates obesity-induced insulin resistance with adipose tissue inflammation10.1038/s41467-017-01232-w2041-1723https://doaj.org/article/67c72e112e95430fb6d3dc4e4e0e79d32017-10-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01232-whttps://doaj.org/toc/2041-1723VLDLR regulates cellular lipoprotein uptake and storage. Here, the authors show that VLDLR, expressed on adipose tissue macrophages, is upregulated in obesity and promotes adipose tissue inflammation by upregulating ceramide production and facilitating M1-like macrophage polarization.Kyung Cheul ShinInjae HwangSung Sik ChoeJeu ParkYul JiJong In KimGha Young LeeSung Hee ChoiJianhong ChingJean-Paul KovalikJae Bum KimNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Kyung Cheul Shin
Injae Hwang
Sung Sik Choe
Jeu Park
Yul Ji
Jong In Kim
Gha Young Lee
Sung Hee Choi
Jianhong Ching
Jean-Paul Kovalik
Jae Bum Kim
Macrophage VLDLR mediates obesity-induced insulin resistance with adipose tissue inflammation
description VLDLR regulates cellular lipoprotein uptake and storage. Here, the authors show that VLDLR, expressed on adipose tissue macrophages, is upregulated in obesity and promotes adipose tissue inflammation by upregulating ceramide production and facilitating M1-like macrophage polarization.
format article
author Kyung Cheul Shin
Injae Hwang
Sung Sik Choe
Jeu Park
Yul Ji
Jong In Kim
Gha Young Lee
Sung Hee Choi
Jianhong Ching
Jean-Paul Kovalik
Jae Bum Kim
author_facet Kyung Cheul Shin
Injae Hwang
Sung Sik Choe
Jeu Park
Yul Ji
Jong In Kim
Gha Young Lee
Sung Hee Choi
Jianhong Ching
Jean-Paul Kovalik
Jae Bum Kim
author_sort Kyung Cheul Shin
title Macrophage VLDLR mediates obesity-induced insulin resistance with adipose tissue inflammation
title_short Macrophage VLDLR mediates obesity-induced insulin resistance with adipose tissue inflammation
title_full Macrophage VLDLR mediates obesity-induced insulin resistance with adipose tissue inflammation
title_fullStr Macrophage VLDLR mediates obesity-induced insulin resistance with adipose tissue inflammation
title_full_unstemmed Macrophage VLDLR mediates obesity-induced insulin resistance with adipose tissue inflammation
title_sort macrophage vldlr mediates obesity-induced insulin resistance with adipose tissue inflammation
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/67c72e112e95430fb6d3dc4e4e0e79d3
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AT injaehwang macrophagevldlrmediatesobesityinducedinsulinresistancewithadiposetissueinflammation
AT sungsikchoe macrophagevldlrmediatesobesityinducedinsulinresistancewithadiposetissueinflammation
AT jeupark macrophagevldlrmediatesobesityinducedinsulinresistancewithadiposetissueinflammation
AT yulji macrophagevldlrmediatesobesityinducedinsulinresistancewithadiposetissueinflammation
AT jonginkim macrophagevldlrmediatesobesityinducedinsulinresistancewithadiposetissueinflammation
AT ghayounglee macrophagevldlrmediatesobesityinducedinsulinresistancewithadiposetissueinflammation
AT sungheechoi macrophagevldlrmediatesobesityinducedinsulinresistancewithadiposetissueinflammation
AT jianhongching macrophagevldlrmediatesobesityinducedinsulinresistancewithadiposetissueinflammation
AT jeanpaulkovalik macrophagevldlrmediatesobesityinducedinsulinresistancewithadiposetissueinflammation
AT jaebumkim macrophagevldlrmediatesobesityinducedinsulinresistancewithadiposetissueinflammation
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