Single-Cell Transcriptome Sequencing and Proteomics Reveal Neonatal Ileum Dynamic Developmental Potentials
We found previously unknown neonatal ileum developmental potentials: specific increases in undifferentiated cells, unique enterocyte differentiation, and time dependent reduction in secretory cells. Specific transcriptional factors (TFs), ligand-receptor pairs, G protein-coupled receptors, transfor...
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American Society for Microbiology
2021
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oai:doaj.org-article:67cc7b8c8ac64464ad3d549361a62c672021-12-02T19:44:32ZSingle-Cell Transcriptome Sequencing and Proteomics Reveal Neonatal Ileum Dynamic Developmental Potentials2379-507710.1128/mSystems.00725-21https://doaj.org/article/67cc7b8c8ac64464ad3d549361a62c672021-10-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mSystems.00725-21https://doaj.org/toc/2379-5077 We found previously unknown neonatal ileum developmental potentials: specific increases in undifferentiated cells, unique enterocyte differentiation, and time dependent reduction in secretory cells. Specific transcriptional factors (TFs), ligand-receptor pairs, G protein-coupled receptors, transforming growth factor β, bone morphogenetic protein signaling pathways, and the gut mucosal microbiota are involved in this process.Qingshi MengLiang ChenBohui XiongBeining KangPengfei ZhangShanlong TangHui HanWei ShenXiaohui FengShengnan FengRuqing ZhongXiangfang TangSheng ZhangHongfu ZhangYong ZhaoAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmSystems, Vol 6, Iss 5 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Microbiology QR1-502 |
| spellingShingle |
Microbiology QR1-502 Qingshi Meng Liang Chen Bohui Xiong Beining Kang Pengfei Zhang Shanlong Tang Hui Han Wei Shen Xiaohui Feng Shengnan Feng Ruqing Zhong Xiangfang Tang Sheng Zhang Hongfu Zhang Yong Zhao Single-Cell Transcriptome Sequencing and Proteomics Reveal Neonatal Ileum Dynamic Developmental Potentials |
| description |
We found previously unknown neonatal ileum developmental potentials: specific increases in undifferentiated cells, unique enterocyte differentiation, and time dependent reduction in secretory cells. Specific transcriptional factors (TFs), ligand-receptor pairs, G protein-coupled receptors, transforming growth factor β, bone morphogenetic protein signaling pathways, and the gut mucosal microbiota are involved in this process. |
| format |
article |
| author |
Qingshi Meng Liang Chen Bohui Xiong Beining Kang Pengfei Zhang Shanlong Tang Hui Han Wei Shen Xiaohui Feng Shengnan Feng Ruqing Zhong Xiangfang Tang Sheng Zhang Hongfu Zhang Yong Zhao |
| author_facet |
Qingshi Meng Liang Chen Bohui Xiong Beining Kang Pengfei Zhang Shanlong Tang Hui Han Wei Shen Xiaohui Feng Shengnan Feng Ruqing Zhong Xiangfang Tang Sheng Zhang Hongfu Zhang Yong Zhao |
| author_sort |
Qingshi Meng |
| title |
Single-Cell Transcriptome Sequencing and Proteomics Reveal Neonatal Ileum Dynamic Developmental Potentials |
| title_short |
Single-Cell Transcriptome Sequencing and Proteomics Reveal Neonatal Ileum Dynamic Developmental Potentials |
| title_full |
Single-Cell Transcriptome Sequencing and Proteomics Reveal Neonatal Ileum Dynamic Developmental Potentials |
| title_fullStr |
Single-Cell Transcriptome Sequencing and Proteomics Reveal Neonatal Ileum Dynamic Developmental Potentials |
| title_full_unstemmed |
Single-Cell Transcriptome Sequencing and Proteomics Reveal Neonatal Ileum Dynamic Developmental Potentials |
| title_sort |
single-cell transcriptome sequencing and proteomics reveal neonatal ileum dynamic developmental potentials |
| publisher |
American Society for Microbiology |
| publishDate |
2021 |
| url |
https://doaj.org/article/67cc7b8c8ac64464ad3d549361a62c67 |
| work_keys_str_mv |
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| _version_ |
1718376087403102208 |