Disrupted functional connectivity between the periaqueductal gray and other brain regions in a rat model of recurrent headache

Abstract Functional connectivity (FC) has been used to investigate the pathophysiology of migraine. We aimed to identify atypical FC between the periaqueductal gray (PAG) and other brain areas in rats induced by repeated meningeal nociception. The rat model was established by infusing an inflammator...

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Autores principales:	Zhihua Jia, Wenjing Tang, Dengfa Zhao, Shengyuan Yu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/67cc8d0450034b119978ba7733c4eb8d
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spelling	oai:doaj.org-article:67cc8d0450034b119978ba7733c4eb8d2021-12-02T11:50:57ZDisrupted functional connectivity between the periaqueductal gray and other brain regions in a rat model of recurrent headache10.1038/s41598-017-04060-62045-2322https://doaj.org/article/67cc8d0450034b119978ba7733c4eb8d2017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-04060-6https://doaj.org/toc/2045-2322Abstract Functional connectivity (FC) has been used to investigate the pathophysiology of migraine. We aimed to identify atypical FC between the periaqueductal gray (PAG) and other brain areas in rats induced by repeated meningeal nociception. The rat model was established by infusing an inflammatory soup (IS) through supradural catheters in conscious rats. Quiescent and face-grooming behaviors were observed to assess nociceptive behavior. FC analysis seeded on the PAG was performed on rats 21 days after IS infusion. The rats exhibited nociceptive behavior correlates of human behaviors associated with migraine after IS infusion. The PAG showed increased FC with the prefrontal cortex, cingulate gyrus, and motor cortex but decreased FC with the basal ganglia, dorsal lateral thalamus, internal capsule and prelimbic cortex in the rat model. The atypical FC of the PAG with brain regions in the rat model that are involved in nociception, somatosensory processing, emotional processing, and pain modulation are consistent with the clinical data from migraineurs, indicate that resting-state FC changes in migraine patients may be a consequence of headache attacks, and further validate this rat model of chronic migraine.Zhihua JiaWenjing TangDengfa ZhaoShengyuan YuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-9 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Zhihua Jia Wenjing Tang Dengfa Zhao Shengyuan Yu Disrupted functional connectivity between the periaqueductal gray and other brain regions in a rat model of recurrent headache
description	Abstract Functional connectivity (FC) has been used to investigate the pathophysiology of migraine. We aimed to identify atypical FC between the periaqueductal gray (PAG) and other brain areas in rats induced by repeated meningeal nociception. The rat model was established by infusing an inflammatory soup (IS) through supradural catheters in conscious rats. Quiescent and face-grooming behaviors were observed to assess nociceptive behavior. FC analysis seeded on the PAG was performed on rats 21 days after IS infusion. The rats exhibited nociceptive behavior correlates of human behaviors associated with migraine after IS infusion. The PAG showed increased FC with the prefrontal cortex, cingulate gyrus, and motor cortex but decreased FC with the basal ganglia, dorsal lateral thalamus, internal capsule and prelimbic cortex in the rat model. The atypical FC of the PAG with brain regions in the rat model that are involved in nociception, somatosensory processing, emotional processing, and pain modulation are consistent with the clinical data from migraineurs, indicate that resting-state FC changes in migraine patients may be a consequence of headache attacks, and further validate this rat model of chronic migraine.
format	article
author	Zhihua Jia Wenjing Tang Dengfa Zhao Shengyuan Yu
author_facet	Zhihua Jia Wenjing Tang Dengfa Zhao Shengyuan Yu
author_sort	Zhihua Jia
title	Disrupted functional connectivity between the periaqueductal gray and other brain regions in a rat model of recurrent headache
title_short	Disrupted functional connectivity between the periaqueductal gray and other brain regions in a rat model of recurrent headache
title_full	Disrupted functional connectivity between the periaqueductal gray and other brain regions in a rat model of recurrent headache
title_fullStr	Disrupted functional connectivity between the periaqueductal gray and other brain regions in a rat model of recurrent headache
title_full_unstemmed	Disrupted functional connectivity between the periaqueductal gray and other brain regions in a rat model of recurrent headache
title_sort	disrupted functional connectivity between the periaqueductal gray and other brain regions in a rat model of recurrent headache
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/67cc8d0450034b119978ba7733c4eb8d
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_version_	1718395168688701440

Disrupted functional connectivity between the periaqueductal gray and other brain regions in a rat model of recurrent headache

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