Antimicrobial performance of mesoporous titania thin films: role of pore size, hydrophobicity, and antibiotic release

Saba Atefyekta,1 Batur Ercan,2,3 Johan Karlsson,1 Erik Taylor,2 Stanley Chung,2 Thomas J Webster,1,4 Martin Andersson1 1Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Gothenburg, Sweden; 2Department of Chemical Engineering, Northeastern University, Boston, MA,...

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Autores principales:	Atefyekta S, Ercan B, Karlsson J, Taylor E, Chung S, Webster TJ, Andersson M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	Mesoporous titania antibacterial drug delivery implant coating Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/67cd165209dc4e4caa721fa6ed7b10a5
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spelling	oai:doaj.org-article:67cd165209dc4e4caa721fa6ed7b10a52021-12-02T00:46:38ZAntimicrobial performance of mesoporous titania thin films: role of pore size, hydrophobicity, and antibiotic release1178-2013https://doaj.org/article/67cd165209dc4e4caa721fa6ed7b10a52016-03-01T00:00:00Zhttps://www.dovepress.com/antimicrobial-performance-of-mesoporous-titania-thin-films-role-of-por-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Saba Atefyekta,1 Batur Ercan,2,3 Johan Karlsson,1 Erik Taylor,2 Stanley Chung,2 Thomas J Webster,1,4 Martin Andersson1 1Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Gothenburg, Sweden; 2Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 3Department of Metallurgical and Materials Engineering, Middle East Technical University, Ankara, Turkey; 4Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia Abstract: Implant-associated infections are undesirable complications that might arise after implant surgery. If the infection is not prevented, it can lead to tremendous cost, trauma, and even life threatening conditions for the patient. Development of an implant coating loaded with antimicrobial substances would be an effective way to improve the success rate of implants. In this study, the in vitro efficacy of mesoporous titania thin films used as a novel antimicrobial release coating was evaluated. Mesoporous titania thin films with pore diameters of 4, 6, and 7 nm were synthesized using the evaporation-induced self-assembly method. The films were characterized and loaded with antimicrobial agents, including vancomycin, gentamicin, and daptomycin. Staphylococcus aureus and Pseudomonas aeruginosa were used to evaluate their effectiveness toward inhibiting bacterial colonization. Drug loading and delivery were studied using a quartz crystal microbalance with dissipation monitoring, which showed successful loading and release of the antibiotics from the surfaces. Results from counting bacterial colony-forming units showed reduced bacterial adhesion on the drug-loaded films. Interestingly, the presence of the pores alone had a desired effect on bacterial colonization, which can be attributed to the documented nanotopographical effect. In summary, this study provides significant promise for the use of mesoporous titania thin films for reducing implant infections. Keywords: mesoporous titania, antibacterial, drug delivery, implant coatingAtefyekta SErcan BKarlsson JTaylor EChung SWebster TJAndersson MDove Medical PressarticleMesoporous titaniaantibacterialdrug deliveryimplant coatingMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss Issue 1, Pp 977-990 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Mesoporous titania antibacterial drug delivery implant coating Medicine (General) R5-920
spellingShingle	Mesoporous titania antibacterial drug delivery implant coating Medicine (General) R5-920 Atefyekta S Ercan B Karlsson J Taylor E Chung S Webster TJ Andersson M Antimicrobial performance of mesoporous titania thin films: role of pore size, hydrophobicity, and antibiotic release
description	Saba Atefyekta,1 Batur Ercan,2,3 Johan Karlsson,1 Erik Taylor,2 Stanley Chung,2 Thomas J Webster,1,4 Martin Andersson1 1Department of Chemistry and Chemical Engineering, Chalmers University of Technology, Gothenburg, Sweden; 2Department of Chemical Engineering, Northeastern University, Boston, MA, USA; 3Department of Metallurgical and Materials Engineering, Middle East Technical University, Ankara, Turkey; 4Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia Abstract: Implant-associated infections are undesirable complications that might arise after implant surgery. If the infection is not prevented, it can lead to tremendous cost, trauma, and even life threatening conditions for the patient. Development of an implant coating loaded with antimicrobial substances would be an effective way to improve the success rate of implants. In this study, the in vitro efficacy of mesoporous titania thin films used as a novel antimicrobial release coating was evaluated. Mesoporous titania thin films with pore diameters of 4, 6, and 7 nm were synthesized using the evaporation-induced self-assembly method. The films were characterized and loaded with antimicrobial agents, including vancomycin, gentamicin, and daptomycin. Staphylococcus aureus and Pseudomonas aeruginosa were used to evaluate their effectiveness toward inhibiting bacterial colonization. Drug loading and delivery were studied using a quartz crystal microbalance with dissipation monitoring, which showed successful loading and release of the antibiotics from the surfaces. Results from counting bacterial colony-forming units showed reduced bacterial adhesion on the drug-loaded films. Interestingly, the presence of the pores alone had a desired effect on bacterial colonization, which can be attributed to the documented nanotopographical effect. In summary, this study provides significant promise for the use of mesoporous titania thin films for reducing implant infections. Keywords: mesoporous titania, antibacterial, drug delivery, implant coating
format	article
author	Atefyekta S Ercan B Karlsson J Taylor E Chung S Webster TJ Andersson M
author_facet	Atefyekta S Ercan B Karlsson J Taylor E Chung S Webster TJ Andersson M
author_sort	Atefyekta S
title	Antimicrobial performance of mesoporous titania thin films: role of pore size, hydrophobicity, and antibiotic release
title_short	Antimicrobial performance of mesoporous titania thin films: role of pore size, hydrophobicity, and antibiotic release
title_full	Antimicrobial performance of mesoporous titania thin films: role of pore size, hydrophobicity, and antibiotic release
title_fullStr	Antimicrobial performance of mesoporous titania thin films: role of pore size, hydrophobicity, and antibiotic release
title_full_unstemmed	Antimicrobial performance of mesoporous titania thin films: role of pore size, hydrophobicity, and antibiotic release
title_sort	antimicrobial performance of mesoporous titania thin films: role of pore size, hydrophobicity, and antibiotic release
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/67cd165209dc4e4caa721fa6ed7b10a5
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Antimicrobial performance of mesoporous titania thin films: role of pore size, hydrophobicity, and antibiotic release

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