Alternatives to the six-minute walk test in pulmonary arterial hypertension.

<h4>Introduction</h4>The physiological response during the endurance shuttle walk test (ESWT), the cycle endurance test (CET) and the incremental shuttle walk test (ISWT) remains unknown in PAH. We tested the hypothesis that endurance tests induce a near-maximal physiological demand comp...

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Autores principales:	Vincent Mainguy, Simon Malenfant, Anne-Sophie Neyron, Didier Saey, François Maltais, Sébastien Bonnet, Steeve Provencher
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/67d127c717f34ea6b0e2afcb383a04f8
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spelling	oai:doaj.org-article:67d127c717f34ea6b0e2afcb383a04f82021-11-25T06:05:20ZAlternatives to the six-minute walk test in pulmonary arterial hypertension.1932-620310.1371/journal.pone.0103626https://doaj.org/article/67d127c717f34ea6b0e2afcb383a04f82014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25111294/pdf/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Introduction</h4>The physiological response during the endurance shuttle walk test (ESWT), the cycle endurance test (CET) and the incremental shuttle walk test (ISWT) remains unknown in PAH. We tested the hypothesis that endurance tests induce a near-maximal physiological demand comparable to incremental tests. We also hypothesized that differences in respiratory response during exercise would be related to the characteristics of the exercise tests.<h4>Methods</h4>Within two weeks, twenty-one PAH patients (mean age: 54(15) years; mean pulmonary arterial pressure: 42(12) mmHg) completed two cycling exercise tests (incremental cardiopulmonary cycling exercise test (CPET) and CET) and three field tests (ISWT, ESWT and six-minute walk test (6MWT)). Physiological parameters were continuously monitored using the same portable telemetric device.<h4>Results</h4>Peak oxygen consumption (VO(2peak)) was similar amongst the five exercise tests (p = 0.90 by ANOVA). Walking distance correlated markedly with the VO(2peak) reached during field tests, especially when weight was taken into account. At 100% exercise, most physiological parameters were similar between incremental and endurance tests. However, the trends overtime differed. In the incremental tests, slopes for these parameters rose steadily over the entire duration of the tests, whereas in the endurance tests, slopes rose sharply from baseline to 25% of maximum exercise at which point they appeared far less steep until test end. Moreover, cycling exercise tests induced higher respiratory exchange ratio, ventilatory demand and enhanced leg fatigue measured subjectively and objectively.<h4>Conclusion</h4>Endurance tests induce a maximal physiological demand in PAH. Differences in peak respiratory response during exercise are related to the modality (cycling vs. walking) rather than the progression (endurance vs. incremental) of the exercise tests.Vincent MainguySimon MalenfantAnne-Sophie NeyronDidier SaeyFrançois MaltaisSébastien BonnetSteeve ProvencherPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 8, p e103626 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Vincent Mainguy Simon Malenfant Anne-Sophie Neyron Didier Saey François Maltais Sébastien Bonnet Steeve Provencher Alternatives to the six-minute walk test in pulmonary arterial hypertension.
description	<h4>Introduction</h4>The physiological response during the endurance shuttle walk test (ESWT), the cycle endurance test (CET) and the incremental shuttle walk test (ISWT) remains unknown in PAH. We tested the hypothesis that endurance tests induce a near-maximal physiological demand comparable to incremental tests. We also hypothesized that differences in respiratory response during exercise would be related to the characteristics of the exercise tests.<h4>Methods</h4>Within two weeks, twenty-one PAH patients (mean age: 54(15) years; mean pulmonary arterial pressure: 42(12) mmHg) completed two cycling exercise tests (incremental cardiopulmonary cycling exercise test (CPET) and CET) and three field tests (ISWT, ESWT and six-minute walk test (6MWT)). Physiological parameters were continuously monitored using the same portable telemetric device.<h4>Results</h4>Peak oxygen consumption (VO(2peak)) was similar amongst the five exercise tests (p = 0.90 by ANOVA). Walking distance correlated markedly with the VO(2peak) reached during field tests, especially when weight was taken into account. At 100% exercise, most physiological parameters were similar between incremental and endurance tests. However, the trends overtime differed. In the incremental tests, slopes for these parameters rose steadily over the entire duration of the tests, whereas in the endurance tests, slopes rose sharply from baseline to 25% of maximum exercise at which point they appeared far less steep until test end. Moreover, cycling exercise tests induced higher respiratory exchange ratio, ventilatory demand and enhanced leg fatigue measured subjectively and objectively.<h4>Conclusion</h4>Endurance tests induce a maximal physiological demand in PAH. Differences in peak respiratory response during exercise are related to the modality (cycling vs. walking) rather than the progression (endurance vs. incremental) of the exercise tests.
format	article
author	Vincent Mainguy Simon Malenfant Anne-Sophie Neyron Didier Saey François Maltais Sébastien Bonnet Steeve Provencher
author_facet	Vincent Mainguy Simon Malenfant Anne-Sophie Neyron Didier Saey François Maltais Sébastien Bonnet Steeve Provencher
author_sort	Vincent Mainguy
title	Alternatives to the six-minute walk test in pulmonary arterial hypertension.
title_short	Alternatives to the six-minute walk test in pulmonary arterial hypertension.
title_full	Alternatives to the six-minute walk test in pulmonary arterial hypertension.
title_fullStr	Alternatives to the six-minute walk test in pulmonary arterial hypertension.
title_full_unstemmed	Alternatives to the six-minute walk test in pulmonary arterial hypertension.
title_sort	alternatives to the six-minute walk test in pulmonary arterial hypertension.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/67d127c717f34ea6b0e2afcb383a04f8
work_keys_str_mv	AT vincentmainguy alternativestothesixminutewalktestinpulmonaryarterialhypertension AT simonmalenfant alternativestothesixminutewalktestinpulmonaryarterialhypertension AT annesophieneyron alternativestothesixminutewalktestinpulmonaryarterialhypertension AT didiersaey alternativestothesixminutewalktestinpulmonaryarterialhypertension AT francoismaltais alternativestothesixminutewalktestinpulmonaryarterialhypertension AT sebastienbonnet alternativestothesixminutewalktestinpulmonaryarterialhypertension AT steeveprovencher alternativestothesixminutewalktestinpulmonaryarterialhypertension
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Alternatives to the six-minute walk test in pulmonary arterial hypertension.

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