Findings of secondary corneal amyloidosis with ultrahigh-resolution optical coherence tomography

Kaoru Araki-Sasaki,1 Yasuhiro Osakabe,2 Hideki Fukuoka,3 Ryuichi Ideta,4 Koji Hirano5 1Department of Ophthalmology, Japan Community Health Care Organization, Hoshigaoka Medical Center, Hirakata, 2Department of Molecular Pathology, Tokyo Medical University, Tokyo, 3Department of Ophthalmology, Kyot...

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Autores principales:	Araki-Sasaki K, Osakabe Y, Fukuoka H, Ideta R, Hirano K
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2014
Materias:	Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/67d15257d9bf4eee99d710d8283e37b7
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spelling	oai:doaj.org-article:67d15257d9bf4eee99d710d8283e37b72021-12-02T06:03:24ZFindings of secondary corneal amyloidosis with ultrahigh-resolution optical coherence tomography1177-5483https://doaj.org/article/67d15257d9bf4eee99d710d8283e37b72014-10-01T00:00:00Zhttp://www.dovepress.com/findings-of-secondary-corneal-amyloidosis-with-ultrahigh-resolution-op-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483 Kaoru Araki-Sasaki,1 Yasuhiro Osakabe,2 Hideki Fukuoka,3 Ryuichi Ideta,4 Koji Hirano5 1Department of Ophthalmology, Japan Community Health Care Organization, Hoshigaoka Medical Center, Hirakata, 2Department of Molecular Pathology, Tokyo Medical University, Tokyo, 3Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, 4Ideta Eye Hospital, Kumamoto, 5Department of Ophthalmology, Ban Buntane Hotokukai Hospital, School of Medicine, Fujita Health University, Nagoya, Japan Purpose: To describe observations by ultrahigh-resolution optical coherence tomography (OCT) in a secondary corneal amyloidosis (SCA) patient with histological analysis of excised tissue. A unique finding under OCT of her fellow eye is also described.Case: A 39-year-old female had suffered from trichiasis in both of her eyes for more than 30 years. Slit-lamp examination showed a milky-white soft mass on her left cornea and a linear opacity on the fellow cornea at the cilia-attached region. OCT demonstrated the presence of a mass region within a thin epithelial layer and no destruction of Bowman’s layer in her left cornea. In the fellow cornea, which exhibited a linear opacity, a high-density spot in Bowman’s layer was observed at the cilia-attached region covered by the epithelial layer, with normal thickness. Histological examination of the excised cornea showed that the mass was positive with both Congo red and antilactoferrin antibody.Conclusion: SCA, amyloid gradually accumulates above Bowman’s layer, occupying the epithelial layer, with no destruction of Bowman’s layer until the advanced stage. A high-density spot in Bowman’s layer might be the first stage of SCA. Keywords: OCT, secondary corneal amyloidosis, lactoferrin, corneaAraki-Sasaki KOsakabe YFukuoka HIdeta RHirano KDove Medical PressarticleOphthalmologyRE1-994ENClinical Ophthalmology, Vol 2014, Iss default, Pp 2115-2119 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ophthalmology RE1-994
spellingShingle	Ophthalmology RE1-994 Araki-Sasaki K Osakabe Y Fukuoka H Ideta R Hirano K Findings of secondary corneal amyloidosis with ultrahigh-resolution optical coherence tomography
description	Kaoru Araki-Sasaki,1 Yasuhiro Osakabe,2 Hideki Fukuoka,3 Ryuichi Ideta,4 Koji Hirano5 1Department of Ophthalmology, Japan Community Health Care Organization, Hoshigaoka Medical Center, Hirakata, 2Department of Molecular Pathology, Tokyo Medical University, Tokyo, 3Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, 4Ideta Eye Hospital, Kumamoto, 5Department of Ophthalmology, Ban Buntane Hotokukai Hospital, School of Medicine, Fujita Health University, Nagoya, Japan Purpose: To describe observations by ultrahigh-resolution optical coherence tomography (OCT) in a secondary corneal amyloidosis (SCA) patient with histological analysis of excised tissue. A unique finding under OCT of her fellow eye is also described.Case: A 39-year-old female had suffered from trichiasis in both of her eyes for more than 30 years. Slit-lamp examination showed a milky-white soft mass on her left cornea and a linear opacity on the fellow cornea at the cilia-attached region. OCT demonstrated the presence of a mass region within a thin epithelial layer and no destruction of Bowman’s layer in her left cornea. In the fellow cornea, which exhibited a linear opacity, a high-density spot in Bowman’s layer was observed at the cilia-attached region covered by the epithelial layer, with normal thickness. Histological examination of the excised cornea showed that the mass was positive with both Congo red and antilactoferrin antibody.Conclusion: SCA, amyloid gradually accumulates above Bowman’s layer, occupying the epithelial layer, with no destruction of Bowman’s layer until the advanced stage. A high-density spot in Bowman’s layer might be the first stage of SCA. Keywords: OCT, secondary corneal amyloidosis, lactoferrin, cornea
format	article
author	Araki-Sasaki K Osakabe Y Fukuoka H Ideta R Hirano K
author_facet	Araki-Sasaki K Osakabe Y Fukuoka H Ideta R Hirano K
author_sort	Araki-Sasaki K
title	Findings of secondary corneal amyloidosis with ultrahigh-resolution optical coherence tomography
title_short	Findings of secondary corneal amyloidosis with ultrahigh-resolution optical coherence tomography
title_full	Findings of secondary corneal amyloidosis with ultrahigh-resolution optical coherence tomography
title_fullStr	Findings of secondary corneal amyloidosis with ultrahigh-resolution optical coherence tomography
title_full_unstemmed	Findings of secondary corneal amyloidosis with ultrahigh-resolution optical coherence tomography
title_sort	findings of secondary corneal amyloidosis with ultrahigh-resolution optical coherence tomography
publisher	Dove Medical Press
publishDate	2014
url	https://doaj.org/article/67d15257d9bf4eee99d710d8283e37b7
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Findings of secondary corneal amyloidosis with ultrahigh-resolution optical coherence tomography

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