Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad3
MRTF and TAZ are mechanosensitive transcriptional coactivators, but how they functionally interact is not clear. Here the authors show that MRFT and TAZ exhibit multilevel crosstalk in expression, transport and transcriptional activity; furthermore, TAZ confers sensitivity to TGFβ activation of the...
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| Autores principales: | , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2016
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/67d278d9789b4beeabd324a5881a18b5 |
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| Sumario: | MRTF and TAZ are mechanosensitive transcriptional coactivators, but how they functionally interact is not clear. Here the authors show that MRFT and TAZ exhibit multilevel crosstalk in expression, transport and transcriptional activity; furthermore, TAZ confers sensitivity to TGFβ activation of the smooth muscle actin promoter. |
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