Negative association of acetate with visceral adipose tissue and insulin levels

Brian T Layden1, Sudha K Yalamanchi1, Thomas MS Wolever2, Andrea Dunaif1, William L Lowe Jr11Division of Endocrinology, Metabolism and Molecular Medicine (BTL, SKY, AD, WLL), Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA; 2Department of Nutritional Sciences (TMSW), Univ...

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Autores principales:	Layden BT, Yalamanchi SK, Wolever TMS, Dunaif A, Lowe Jr WL
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/67d7c074f52e49aaa1bd20cbe407d14c
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spelling	oai:doaj.org-article:67d7c074f52e49aaa1bd20cbe407d14c2021-12-02T00:28:51ZNegative association of acetate with visceral adipose tissue and insulin levels1178-7007https://doaj.org/article/67d7c074f52e49aaa1bd20cbe407d14c2012-02-01T00:00:00Zhttp://www.dovepress.com/negative-association-of-acetate-with-visceral-adipose-tissue-and-insul-a9374https://doaj.org/toc/1178-7007Brian T Layden1, Sudha K Yalamanchi1, Thomas MS Wolever2, Andrea Dunaif1, William L Lowe Jr11Division of Endocrinology, Metabolism and Molecular Medicine (BTL, SKY, AD, WLL), Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA; 2Department of Nutritional Sciences (TMSW), University of Toronto, Toronto, CanadaBackground: The composition of gut flora has been proposed as a cause of obesity, a major risk factor for type 2 diabetes. The objective of this study was to assess whether serum short chain fatty acids, a major by-product of fermentation in gut flora, are associated with obesity and/or diabetes-related traits (insulin sensitivity and secretion).Methods: The association of serum short chain fatty acids levels with measures of obesity was assessed using body mass index, computerized tomography scan, and dual photon X-ray absorptiometry scan. Insulin sensitivity and insulin secretion were both determined from an oral glucose tolerance test and insulin sensitivity was also determined from a hyperinsulinemic euglycemic clamp.Results: In this population of young, obese women, acetate was negatively associated with visceral adipose tissue determined by computerized tomography scan and dual photon X-ray absorptiometry scan, but not body mass index. The level of the short chain fatty acids acetate, but not propionate or butyrate, was also negatively associated with fasting serum insulin and 2 hour insulin levels in the oral glucose tolerance test.Conclusions: In this population, serum acetate was negatively associated with visceral adipose tissue and insulin levels. Future studies need to verify these findings and expand on these observations in larger cohorts of subjects.Keywords: obesity, insulin, gut flora, short chain fatty acids&nbsp;Layden BTYalamanchi SKWolever TMSDunaif ALowe Jr WLDove Medical PressarticleSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol 2012, Iss default, Pp 49-55 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Specialties of internal medicine RC581-951
spellingShingle	Specialties of internal medicine RC581-951 Layden BT Yalamanchi SK Wolever TMS Dunaif A Lowe Jr WL Negative association of acetate with visceral adipose tissue and insulin levels
description	Brian T Layden1, Sudha K Yalamanchi1, Thomas MS Wolever2, Andrea Dunaif1, William L Lowe Jr11Division of Endocrinology, Metabolism and Molecular Medicine (BTL, SKY, AD, WLL), Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA; 2Department of Nutritional Sciences (TMSW), University of Toronto, Toronto, CanadaBackground: The composition of gut flora has been proposed as a cause of obesity, a major risk factor for type 2 diabetes. The objective of this study was to assess whether serum short chain fatty acids, a major by-product of fermentation in gut flora, are associated with obesity and/or diabetes-related traits (insulin sensitivity and secretion).Methods: The association of serum short chain fatty acids levels with measures of obesity was assessed using body mass index, computerized tomography scan, and dual photon X-ray absorptiometry scan. Insulin sensitivity and insulin secretion were both determined from an oral glucose tolerance test and insulin sensitivity was also determined from a hyperinsulinemic euglycemic clamp.Results: In this population of young, obese women, acetate was negatively associated with visceral adipose tissue determined by computerized tomography scan and dual photon X-ray absorptiometry scan, but not body mass index. The level of the short chain fatty acids acetate, but not propionate or butyrate, was also negatively associated with fasting serum insulin and 2 hour insulin levels in the oral glucose tolerance test.Conclusions: In this population, serum acetate was negatively associated with visceral adipose tissue and insulin levels. Future studies need to verify these findings and expand on these observations in larger cohorts of subjects.Keywords: obesity, insulin, gut flora, short chain fatty acids&nbsp;
format	article
author	Layden BT Yalamanchi SK Wolever TMS Dunaif A Lowe Jr WL
author_facet	Layden BT Yalamanchi SK Wolever TMS Dunaif A Lowe Jr WL
author_sort	Layden BT
title	Negative association of acetate with visceral adipose tissue and insulin levels
title_short	Negative association of acetate with visceral adipose tissue and insulin levels
title_full	Negative association of acetate with visceral adipose tissue and insulin levels
title_fullStr	Negative association of acetate with visceral adipose tissue and insulin levels
title_full_unstemmed	Negative association of acetate with visceral adipose tissue and insulin levels
title_sort	negative association of acetate with visceral adipose tissue and insulin levels
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/67d7c074f52e49aaa1bd20cbe407d14c
work_keys_str_mv	AT laydenbt negativeassociationofacetatewithvisceraladiposetissueandinsulinlevels AT yalamanchisk negativeassociationofacetatewithvisceraladiposetissueandinsulinlevels AT wolevertms negativeassociationofacetatewithvisceraladiposetissueandinsulinlevels AT dunaifa negativeassociationofacetatewithvisceraladiposetissueandinsulinlevels AT lowejrwl negativeassociationofacetatewithvisceraladiposetissueandinsulinlevels
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Negative association of acetate with visceral adipose tissue and insulin levels

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