Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer

During colorectal inflammation and cancer, myeloid cells accumulate in the spleen and suppress the host immunity response. In this study, the authors use a mouse model of colitis to demonstrate that upon vagus stimulation splenic memory T cells release TFF2, which suppresses the expansion of myeloid...

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Autores principales:	Zina Dubeykovskaya, Yiling Si, Xiaowei Chen, Daniel L. Worthley, Bernhard W. Renz, Aleksandra M. Urbanska, Yoku Hayakawa, Ting Xu, C. Benedikt Westphalen, Alexander Dubeykovskiy, Duan Chen, Richard A. Friedman, Samuel Asfaha, Karan Nagar, Yagnesh Tailor, Sureshkumar Muthupalani, James G. Fox, Jan Kitajewski, Timothy C. Wang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/67d8a761a2b64f5c8b8c4095b1685dfc
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spelling	oai:doaj.org-article:67d8a761a2b64f5c8b8c4095b1685dfc2021-12-02T16:49:25ZNeural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer10.1038/ncomms105172041-1723https://doaj.org/article/67d8a761a2b64f5c8b8c4095b1685dfc2016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10517https://doaj.org/toc/2041-1723During colorectal inflammation and cancer, myeloid cells accumulate in the spleen and suppress the host immunity response. In this study, the authors use a mouse model of colitis to demonstrate that upon vagus stimulation splenic memory T cells release TFF2, which suppresses the expansion of myeloid cells and cancer progression.Zina DubeykovskayaYiling SiXiaowei ChenDaniel L. WorthleyBernhard W. RenzAleksandra M. UrbanskaYoku HayakawaTing XuC. Benedikt WestphalenAlexander DubeykovskiyDuan ChenRichard A. FriedmanSamuel AsfahaKaran NagarYagnesh TailorSureshkumar MuthupalaniJames G. FoxJan KitajewskiTimothy C. WangNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Zina Dubeykovskaya Yiling Si Xiaowei Chen Daniel L. Worthley Bernhard W. Renz Aleksandra M. Urbanska Yoku Hayakawa Ting Xu C. Benedikt Westphalen Alexander Dubeykovskiy Duan Chen Richard A. Friedman Samuel Asfaha Karan Nagar Yagnesh Tailor Sureshkumar Muthupalani James G. Fox Jan Kitajewski Timothy C. Wang Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer
description	During colorectal inflammation and cancer, myeloid cells accumulate in the spleen and suppress the host immunity response. In this study, the authors use a mouse model of colitis to demonstrate that upon vagus stimulation splenic memory T cells release TFF2, which suppresses the expansion of myeloid cells and cancer progression.
format	article
author	Zina Dubeykovskaya Yiling Si Xiaowei Chen Daniel L. Worthley Bernhard W. Renz Aleksandra M. Urbanska Yoku Hayakawa Ting Xu C. Benedikt Westphalen Alexander Dubeykovskiy Duan Chen Richard A. Friedman Samuel Asfaha Karan Nagar Yagnesh Tailor Sureshkumar Muthupalani James G. Fox Jan Kitajewski Timothy C. Wang
author_facet	Zina Dubeykovskaya Yiling Si Xiaowei Chen Daniel L. Worthley Bernhard W. Renz Aleksandra M. Urbanska Yoku Hayakawa Ting Xu C. Benedikt Westphalen Alexander Dubeykovskiy Duan Chen Richard A. Friedman Samuel Asfaha Karan Nagar Yagnesh Tailor Sureshkumar Muthupalani James G. Fox Jan Kitajewski Timothy C. Wang
author_sort	Zina Dubeykovskaya
title	Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer
title_short	Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer
title_full	Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer
title_fullStr	Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer
title_full_unstemmed	Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer
title_sort	neural innervation stimulates splenic tff2 to arrest myeloid cell expansion and cancer
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/67d8a761a2b64f5c8b8c4095b1685dfc
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Neural innervation stimulates splenic TFF2 to arrest myeloid cell expansion and cancer

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