CHARACTERISTICS AND ROLE OF MACROPHAGES IN PATHOGENESIS OF ACUTE AND CHRONIC LUNG DISEASES

Macrophages are among the most abundant cells of the respiratory tract, being characterized by their ability to have different phenotypes, depending on signals from the microenvironment (classically activated M1, alternatively activated M2). Despite contradictory literature data describing role of v...

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Autores principales:	A. A. Nikonova, M. R. Khaitov, R. M. Khaitov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2017
Materias:	macrophages asthma copd bacteria viruses monocytes monocytes polarization markers Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/67da7420628648cd9a90b5c419f10790
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spelling	oai:doaj.org-article:67da7420628648cd9a90b5c419f107902021-11-18T08:03:46ZCHARACTERISTICS AND ROLE OF MACROPHAGES IN PATHOGENESIS OF ACUTE AND CHRONIC LUNG DISEASES1563-06252313-741X10.15789/1563-0625-2017-6-657-672https://doaj.org/article/67da7420628648cd9a90b5c419f107902017-12-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/1390https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XMacrophages are among the most abundant cells of the respiratory tract, being characterized by their ability to have different phenotypes, depending on signals from the microenvironment (classically activated M1, alternatively activated M2). Despite contradictory literature data describing role of various macrophage phenotypes, they appear to be coupled to the systems protecting the organism from infectious pathogens and preventing development of excessive tissue responses. Phenotypical changes of lung macrophages are found in various respiratory diseases including bronchial asthma, chronic obstructive pulmonary disease, pulmonary fibrosis and infectious conditions. In this review article, we focused on the biology, origin and characterization of different macrophage phenotypes, and presented current data highlighting their role in development of chronic lung diseases, i.e., bronchial asthma, chronic obstructive pulmonary disease and acute infectious diseases.A. A. NikonovaM. R. KhaitovR. M. KhaitovSPb RAACIarticlemacrophagesasthmacopdbacteriavirusesmonocytesmonocytes polarizationmarkersImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 19, Iss 6, Pp 657-672 (2017)
institution	DOAJ
collection	DOAJ
language	RU
topic	macrophages asthma copd bacteria viruses monocytes monocytes polarization markers Immunologic diseases. Allergy RC581-607
spellingShingle	macrophages asthma copd bacteria viruses monocytes monocytes polarization markers Immunologic diseases. Allergy RC581-607 A. A. Nikonova M. R. Khaitov R. M. Khaitov CHARACTERISTICS AND ROLE OF MACROPHAGES IN PATHOGENESIS OF ACUTE AND CHRONIC LUNG DISEASES
description	Macrophages are among the most abundant cells of the respiratory tract, being characterized by their ability to have different phenotypes, depending on signals from the microenvironment (classically activated M1, alternatively activated M2). Despite contradictory literature data describing role of various macrophage phenotypes, they appear to be coupled to the systems protecting the organism from infectious pathogens and preventing development of excessive tissue responses. Phenotypical changes of lung macrophages are found in various respiratory diseases including bronchial asthma, chronic obstructive pulmonary disease, pulmonary fibrosis and infectious conditions. In this review article, we focused on the biology, origin and characterization of different macrophage phenotypes, and presented current data highlighting their role in development of chronic lung diseases, i.e., bronchial asthma, chronic obstructive pulmonary disease and acute infectious diseases.
format	article
author	A. A. Nikonova M. R. Khaitov R. M. Khaitov
author_facet	A. A. Nikonova M. R. Khaitov R. M. Khaitov
author_sort	A. A. Nikonova
title	CHARACTERISTICS AND ROLE OF MACROPHAGES IN PATHOGENESIS OF ACUTE AND CHRONIC LUNG DISEASES
title_short	CHARACTERISTICS AND ROLE OF MACROPHAGES IN PATHOGENESIS OF ACUTE AND CHRONIC LUNG DISEASES
title_full	CHARACTERISTICS AND ROLE OF MACROPHAGES IN PATHOGENESIS OF ACUTE AND CHRONIC LUNG DISEASES
title_fullStr	CHARACTERISTICS AND ROLE OF MACROPHAGES IN PATHOGENESIS OF ACUTE AND CHRONIC LUNG DISEASES
title_full_unstemmed	CHARACTERISTICS AND ROLE OF MACROPHAGES IN PATHOGENESIS OF ACUTE AND CHRONIC LUNG DISEASES
title_sort	characteristics and role of macrophages in pathogenesis of acute and chronic lung diseases
publisher	SPb RAACI
publishDate	2017
url	https://doaj.org/article/67da7420628648cd9a90b5c419f10790
work_keys_str_mv	AT aanikonova characteristicsandroleofmacrophagesinpathogenesisofacuteandchroniclungdiseases AT mrkhaitov characteristicsandroleofmacrophagesinpathogenesisofacuteandchroniclungdiseases AT rmkhaitov characteristicsandroleofmacrophagesinpathogenesisofacuteandchroniclungdiseases
_version_	1718422355616727040

CHARACTERISTICS AND ROLE OF MACROPHAGES IN PATHOGENESIS OF ACUTE AND CHRONIC LUNG DISEASES

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