Persistent Plasmodium falciparum infections enhance transmission-reducing immunity development

Abstract Subclinical infections that serve as reservoir populations to drive transmission remain a hurdle to malaria control. Data on infection dynamics in a geographical area is required to strategically design and implement malaria interventions. In a longitudinal cohort, we monitored Plasmodium f...

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Autores principales:	Ruth Ayanful-Torgby, Esther Sarpong, Hamza B. Abagna, Dickson Donu, Evans Obboh, Benedicta A. Mensah, Joshua Adjah, Kim C. Williamson, Linda E. Amoah
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/67e124d1d66141ab814f39334eb6ab06
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spelling	oai:doaj.org-article:67e124d1d66141ab814f39334eb6ab062021-11-08T10:54:45ZPersistent Plasmodium falciparum infections enhance transmission-reducing immunity development10.1038/s41598-021-00973-52045-2322https://doaj.org/article/67e124d1d66141ab814f39334eb6ab062021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-00973-5https://doaj.org/toc/2045-2322Abstract Subclinical infections that serve as reservoir populations to drive transmission remain a hurdle to malaria control. Data on infection dynamics in a geographical area is required to strategically design and implement malaria interventions. In a longitudinal cohort, we monitored Plasmodium falciparum infection prevalence and persistence, and anti-parasite immunity to gametocyte and asexual antigens for 10 weeks. Of the 100 participants, only 11 were never infected, whilst 16 had persistent infections detected by reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR), and one participant had microscopic parasites at all visits. Over 70% of the participants were infected three or more times, and submicroscopic gametocyte prevalence was high, ≥ 48% of the parasite carriers. Naturally induced responses against recombinant Pfs48/45.6C, Pfs230proC, and EBA175RIII–V antigens were not associated with either infection status or gametocyte carriage, but the antigen-specific IgG titers inversely correlated with parasite and gametocyte densities consistent with partial immunity. Longitudinal analysis of gametocyte diversity indicated at least four distinct clones circulated throughout the study period. The high prevalence of children infected with distinct gametocyte clones coupled with marked variation in infection status at the individual level suggests ongoing transmission and should be targeted in malaria control programs.Ruth Ayanful-TorgbyEsther SarpongHamza B. AbagnaDickson DonuEvans ObbohBenedicta A. MensahJoshua AdjahKim C. WilliamsonLinda E. AmoahNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ruth Ayanful-Torgby Esther Sarpong Hamza B. Abagna Dickson Donu Evans Obboh Benedicta A. Mensah Joshua Adjah Kim C. Williamson Linda E. Amoah Persistent Plasmodium falciparum infections enhance transmission-reducing immunity development
description	Abstract Subclinical infections that serve as reservoir populations to drive transmission remain a hurdle to malaria control. Data on infection dynamics in a geographical area is required to strategically design and implement malaria interventions. In a longitudinal cohort, we monitored Plasmodium falciparum infection prevalence and persistence, and anti-parasite immunity to gametocyte and asexual antigens for 10 weeks. Of the 100 participants, only 11 were never infected, whilst 16 had persistent infections detected by reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR), and one participant had microscopic parasites at all visits. Over 70% of the participants were infected three or more times, and submicroscopic gametocyte prevalence was high, ≥ 48% of the parasite carriers. Naturally induced responses against recombinant Pfs48/45.6C, Pfs230proC, and EBA175RIII–V antigens were not associated with either infection status or gametocyte carriage, but the antigen-specific IgG titers inversely correlated with parasite and gametocyte densities consistent with partial immunity. Longitudinal analysis of gametocyte diversity indicated at least four distinct clones circulated throughout the study period. The high prevalence of children infected with distinct gametocyte clones coupled with marked variation in infection status at the individual level suggests ongoing transmission and should be targeted in malaria control programs.
format	article
author	Ruth Ayanful-Torgby Esther Sarpong Hamza B. Abagna Dickson Donu Evans Obboh Benedicta A. Mensah Joshua Adjah Kim C. Williamson Linda E. Amoah
author_facet	Ruth Ayanful-Torgby Esther Sarpong Hamza B. Abagna Dickson Donu Evans Obboh Benedicta A. Mensah Joshua Adjah Kim C. Williamson Linda E. Amoah
author_sort	Ruth Ayanful-Torgby
title	Persistent Plasmodium falciparum infections enhance transmission-reducing immunity development
title_short	Persistent Plasmodium falciparum infections enhance transmission-reducing immunity development
title_full	Persistent Plasmodium falciparum infections enhance transmission-reducing immunity development
title_fullStr	Persistent Plasmodium falciparum infections enhance transmission-reducing immunity development
title_full_unstemmed	Persistent Plasmodium falciparum infections enhance transmission-reducing immunity development
title_sort	persistent plasmodium falciparum infections enhance transmission-reducing immunity development
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/67e124d1d66141ab814f39334eb6ab06
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Persistent Plasmodium falciparum infections enhance transmission-reducing immunity development

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