Therapeutic paradigm of dual targeting VEGF and PDGF for effectively treating FGF-2 off-target tumors

Therapeutic paradigm of dual targeting VEGF and PDGF for effectively treating FGF-2 off-target tumors

Anti-VEGF therapy has many limitations that might be resolved by using combination treatment approaches. Here, the authors demonstrate that the dual-targeting of VEGF and PDGF is required for targeting resistant FGF2+ tumors which depend on the recruitment of pericytes on tumor microvessels.

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Detalles Bibliográficos
Autores principales: Kayoko Hosaka, Yunlong Yang, Takahiro Seki, Qiqiao Du, Xu Jing, Xingkang He, Jieyu Wu, Yin Zhang, Hiromasa Morikawa, Masaki Nakamura, Martin Scherzer, Xiaoting Sun, Yuanfu Xu, Tao Cheng, Xuri Li, Xialin Liu, Qi Li, Yizhi Liu, An Hong, Yuguo Chen, Yihai Cao
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
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Acceso en línea:https://doaj.org/article/67e5eca4e69c483cb274470b002be274
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Descripción
Sumario:Anti-VEGF therapy has many limitations that might be resolved by using combination treatment approaches. Here, the authors demonstrate that the dual-targeting of VEGF and PDGF is required for targeting resistant FGF2+ tumors which depend on the recruitment of pericytes on tumor microvessels.

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