Therapeutic paradigm of dual targeting VEGF and PDGF for effectively treating FGF-2 off-target tumors

Therapeutic paradigm of dual targeting VEGF and PDGF for effectively treating FGF-2 off-target tumors

Anti-VEGF therapy has many limitations that might be resolved by using combination treatment approaches. Here, the authors demonstrate that the dual-targeting of VEGF and PDGF is required for targeting resistant FGF2+ tumors which depend on the recruitment of pericytes on tumor microvessels.

Saved in:
Bibliographic Details
Main Authors: Kayoko Hosaka, Yunlong Yang, Takahiro Seki, Qiqiao Du, Xu Jing, Xingkang He, Jieyu Wu, Yin Zhang, Hiromasa Morikawa, Masaki Nakamura, Martin Scherzer, Xiaoting Sun, Yuanfu Xu, Tao Cheng, Xuri Li, Xialin Liu, Qi Li, Yizhi Liu, An Hong, Yuguo Chen, Yihai Cao
Format: article
Language:EN
Published: Nature Portfolio 2020
Subjects:
Science
Q
Online Access:https://doaj.org/article/67e5eca4e69c483cb274470b002be274
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doaj.org/article/67e5eca4e69c483cb274470b002be274

Similar Items