Reduction in Epigenetic Age Acceleration Is Related to Empathy in Mothers with Neglectful Caregiving

DNA methylation clocks are used as molecular estimators of epigenetic age, but with little evidence in mothers and none in neglectful mothering. We investigated differences in epigenetic age acceleration (EAA) and the role of empathy using the PhenoAge clock. We collected saliva samples from mothers...

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Autores principales:	Silvia Herrero-Roldán, María José Rodrigo, Juan A. Hernández-Cabrera, Colter Mitchell, Maykel López, Julia Alcoba-Florez, Jonah Fisher, Fernanda Espinosa, Inmaculada León
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	DNA methylation biological clock epigenetic aging child neglect personality traits Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/67e6496273fb4871899f7f7d51302f5c
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spelling	oai:doaj.org-article:67e6496273fb4871899f7f7d51302f5c2021-11-25T16:56:04ZReduction in Epigenetic Age Acceleration Is Related to Empathy in Mothers with Neglectful Caregiving10.3390/brainsci111113762076-3425https://doaj.org/article/67e6496273fb4871899f7f7d51302f5c2021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3425/11/11/1376https://doaj.org/toc/2076-3425DNA methylation clocks are used as molecular estimators of epigenetic age, but with little evidence in mothers and none in neglectful mothering. We investigated differences in epigenetic age acceleration (EAA) and the role of empathy using the PhenoAge clock. We collected saliva samples from mothers with extreme disregard for their child’s needs (50 in the neglect group, NG) and mothers with non-neglectful caregiving (87 in the control group, CG). Mothers completed an empathy scale, along with questionnaires of their own childhood maltreatment, adverse life events and psychiatric disorders. Sociodemographic variables potentially affecting EAA were also measured. The ANCOVA solution showed a significant increase in EAA in the NG compared to the CG, after adjustment for maternal age, number of pregnancies, financial assistance, adverse events, childhood maltreatment and psychiatric disorder. The group interaction effects showed a reduction in EAA for greater empathic concern and for a higher education level both as positive factors, and an increment in EAA for mothers living in a two-parent family as a risk factor, all in the NG. Our findings open the search for protective factors of EAA associated with caregiver behavior to reduce health vulnerabilities and poor social functioning, especially for mothers at risk of maladaptive caregiving.Silvia Herrero-RoldánMaría José RodrigoJuan A. Hernández-CabreraColter MitchellMaykel LópezJulia Alcoba-FlorezJonah FisherFernanda EspinosaInmaculada LeónMDPI AGarticleDNA methylationbiological clockepigenetic agingchild neglectpersonality traitsNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENBrain Sciences, Vol 11, Iss 1376, p 1376 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	DNA methylation biological clock epigenetic aging child neglect personality traits Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	DNA methylation biological clock epigenetic aging child neglect personality traits Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Silvia Herrero-Roldán María José Rodrigo Juan A. Hernández-Cabrera Colter Mitchell Maykel López Julia Alcoba-Florez Jonah Fisher Fernanda Espinosa Inmaculada León Reduction in Epigenetic Age Acceleration Is Related to Empathy in Mothers with Neglectful Caregiving
description	DNA methylation clocks are used as molecular estimators of epigenetic age, but with little evidence in mothers and none in neglectful mothering. We investigated differences in epigenetic age acceleration (EAA) and the role of empathy using the PhenoAge clock. We collected saliva samples from mothers with extreme disregard for their child’s needs (50 in the neglect group, NG) and mothers with non-neglectful caregiving (87 in the control group, CG). Mothers completed an empathy scale, along with questionnaires of their own childhood maltreatment, adverse life events and psychiatric disorders. Sociodemographic variables potentially affecting EAA were also measured. The ANCOVA solution showed a significant increase in EAA in the NG compared to the CG, after adjustment for maternal age, number of pregnancies, financial assistance, adverse events, childhood maltreatment and psychiatric disorder. The group interaction effects showed a reduction in EAA for greater empathic concern and for a higher education level both as positive factors, and an increment in EAA for mothers living in a two-parent family as a risk factor, all in the NG. Our findings open the search for protective factors of EAA associated with caregiver behavior to reduce health vulnerabilities and poor social functioning, especially for mothers at risk of maladaptive caregiving.
format	article
author	Silvia Herrero-Roldán María José Rodrigo Juan A. Hernández-Cabrera Colter Mitchell Maykel López Julia Alcoba-Florez Jonah Fisher Fernanda Espinosa Inmaculada León
author_facet	Silvia Herrero-Roldán María José Rodrigo Juan A. Hernández-Cabrera Colter Mitchell Maykel López Julia Alcoba-Florez Jonah Fisher Fernanda Espinosa Inmaculada León
author_sort	Silvia Herrero-Roldán
title	Reduction in Epigenetic Age Acceleration Is Related to Empathy in Mothers with Neglectful Caregiving
title_short	Reduction in Epigenetic Age Acceleration Is Related to Empathy in Mothers with Neglectful Caregiving
title_full	Reduction in Epigenetic Age Acceleration Is Related to Empathy in Mothers with Neglectful Caregiving
title_fullStr	Reduction in Epigenetic Age Acceleration Is Related to Empathy in Mothers with Neglectful Caregiving
title_full_unstemmed	Reduction in Epigenetic Age Acceleration Is Related to Empathy in Mothers with Neglectful Caregiving
title_sort	reduction in epigenetic age acceleration is related to empathy in mothers with neglectful caregiving
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/67e6496273fb4871899f7f7d51302f5c
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Reduction in Epigenetic Age Acceleration Is Related to Empathy in Mothers with Neglectful Caregiving

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