Evaluation of Corneal Epithelial Thickness and Dry Eye Disease Tests in Thalassemic Adolescents

Weam Mohamed Ebeid,1 Mahmoud Adel Kenny,2 Tamer AbdelFattah Badran1 1Department of Ophthalmology, Faculty of Medicine, Ain Shams University, Cairo, Egypt; 2Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, EgyptCorrespondence: Weam Mohamed EbeidFaculty of Medicine, Ain Sham...

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Autores principales:	Ebeid WM, Kenny MA, Badran TA
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	dry eye thalassemia major corneal epithelial map osdi questionnaire anterior segment optic coherence tomography. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/67e80a01d9d9439c85c2a0c07e83c544
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spelling	oai:doaj.org-article:67e80a01d9d9439c85c2a0c07e83c5442021-12-02T13:24:07ZEvaluation of Corneal Epithelial Thickness and Dry Eye Disease Tests in Thalassemic Adolescents1177-5483https://doaj.org/article/67e80a01d9d9439c85c2a0c07e83c5442021-04-01T00:00:00Zhttps://www.dovepress.com/evaluation-of-corneal-epithelial-thickness-and-dry-eye-disease-tests-i-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Weam Mohamed Ebeid,1 Mahmoud Adel Kenny,2 Tamer AbdelFattah Badran1 1Department of Ophthalmology, Faculty of Medicine, Ain Shams University, Cairo, Egypt; 2Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, EgyptCorrespondence: Weam Mohamed EbeidFaculty of Medicine, Ain Shams University, 78 First District, Fifth Settlement, Cairo, 11861, EgyptTel +20 1003785838Email weam.ebeid@med.asu.edu.egPurpose: To assess dry eye disease (DED) in thalassemic adolescents by evaluating corneal epithelial thickness (CET) and various dry eye clinical tests and correlate them to tissue iron overload.Methods: The study included 120 Beta-thalassemia patients (11 to 18 years) and 120 matched controls. CET maps were captured using anterior segment optical coherence tomography. OSDI questionnaire was completed. Dry eye tests included Schirmer test, tear film breakup time &lrm;&lrm; (TBUT), and ocular surface staining (OSS) with fluorescein and lissamine green. We recorded serum ferritin &lrm;level, and liver iron concentration (LIC) measured by magnetic resonance imaging.Results: Superior and inferior CET was thinner, while map standard deviation (MSD) was higher in thalassemics compared to controls (all P&lrm;< 0.001&lrm;). Thalassemic group also showed higher OSDI scores&lrm; (P&lrm;< 0.001), shorter TBUT &lrm;&lrm;(P&lrm;< 0.001&lrm;), and higher OSS grades (P&lrm;< 0.001&lrm;). Both superior and inferior CET was correlated positively with TBUT, and negatively with OSS (all P < 0.001). Serum ferritin and LIC showed negative correlations with CET (superior and inferior, both P< 0.001), positive correlations with MSD, P< 0.001, as well as with TBUT (P< 0.001), OSS &lrm;(P< 0.001), and OSDI scores (P< 0.001).Conclusion: Thalassemic adolescents had thinner CET with higher thickness’ variability, shorter TBUT and more marked OSS&lrm; than controls. Correlation of higher serum ferritin and hepatic iron overload with irregular epithelial thinning and more affected dry eye tests results supports our hypothesis that high tissue iron levels could play a pivotal role in DED pathogenesis in thalassemic patients.Keywords: dry eye, thalassemia major, corneal epithelial map, OSDI questionnaire, anterior segment optic coherence tomographyEbeid WMKenny MABadran TADove Medical Pressarticledry eyethalassemia majorcorneal epithelial maposdi questionnaireanterior segment optic coherence tomography.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 15, Pp 1425-1431 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	dry eye thalassemia major corneal epithelial map osdi questionnaire anterior segment optic coherence tomography. Ophthalmology RE1-994
spellingShingle	dry eye thalassemia major corneal epithelial map osdi questionnaire anterior segment optic coherence tomography. Ophthalmology RE1-994 Ebeid WM Kenny MA Badran TA Evaluation of Corneal Epithelial Thickness and Dry Eye Disease Tests in Thalassemic Adolescents
description	Weam Mohamed Ebeid,1 Mahmoud Adel Kenny,2 Tamer AbdelFattah Badran1 1Department of Ophthalmology, Faculty of Medicine, Ain Shams University, Cairo, Egypt; 2Department of Pediatrics, Faculty of Medicine, Ain Shams University, Cairo, EgyptCorrespondence: Weam Mohamed EbeidFaculty of Medicine, Ain Shams University, 78 First District, Fifth Settlement, Cairo, 11861, EgyptTel +20 1003785838Email weam.ebeid@med.asu.edu.egPurpose: To assess dry eye disease (DED) in thalassemic adolescents by evaluating corneal epithelial thickness (CET) and various dry eye clinical tests and correlate them to tissue iron overload.Methods: The study included 120 Beta-thalassemia patients (11 to 18 years) and 120 matched controls. CET maps were captured using anterior segment optical coherence tomography. OSDI questionnaire was completed. Dry eye tests included Schirmer test, tear film breakup time &lrm;&lrm; (TBUT), and ocular surface staining (OSS) with fluorescein and lissamine green. We recorded serum ferritin &lrm;level, and liver iron concentration (LIC) measured by magnetic resonance imaging.Results: Superior and inferior CET was thinner, while map standard deviation (MSD) was higher in thalassemics compared to controls (all P&lrm;< 0.001&lrm;). Thalassemic group also showed higher OSDI scores&lrm; (P&lrm;< 0.001), shorter TBUT &lrm;&lrm;(P&lrm;< 0.001&lrm;), and higher OSS grades (P&lrm;< 0.001&lrm;). Both superior and inferior CET was correlated positively with TBUT, and negatively with OSS (all P < 0.001). Serum ferritin and LIC showed negative correlations with CET (superior and inferior, both P< 0.001), positive correlations with MSD, P< 0.001, as well as with TBUT (P< 0.001), OSS &lrm;(P< 0.001), and OSDI scores (P< 0.001).Conclusion: Thalassemic adolescents had thinner CET with higher thickness’ variability, shorter TBUT and more marked OSS&lrm; than controls. Correlation of higher serum ferritin and hepatic iron overload with irregular epithelial thinning and more affected dry eye tests results supports our hypothesis that high tissue iron levels could play a pivotal role in DED pathogenesis in thalassemic patients.Keywords: dry eye, thalassemia major, corneal epithelial map, OSDI questionnaire, anterior segment optic coherence tomography
format	article
author	Ebeid WM Kenny MA Badran TA
author_facet	Ebeid WM Kenny MA Badran TA
author_sort	Ebeid WM
title	Evaluation of Corneal Epithelial Thickness and Dry Eye Disease Tests in Thalassemic Adolescents
title_short	Evaluation of Corneal Epithelial Thickness and Dry Eye Disease Tests in Thalassemic Adolescents
title_full	Evaluation of Corneal Epithelial Thickness and Dry Eye Disease Tests in Thalassemic Adolescents
title_fullStr	Evaluation of Corneal Epithelial Thickness and Dry Eye Disease Tests in Thalassemic Adolescents
title_full_unstemmed	Evaluation of Corneal Epithelial Thickness and Dry Eye Disease Tests in Thalassemic Adolescents
title_sort	evaluation of corneal epithelial thickness and dry eye disease tests in thalassemic adolescents
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/67e80a01d9d9439c85c2a0c07e83c544
work_keys_str_mv	AT ebeidwm evaluationofcornealepithelialthicknessanddryeyediseasetestsinthalassemicadolescents AT kennyma evaluationofcornealepithelialthicknessanddryeyediseasetestsinthalassemicadolescents AT badranta evaluationofcornealepithelialthicknessanddryeyediseasetestsinthalassemicadolescents
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Evaluation of Corneal Epithelial Thickness and Dry Eye Disease Tests in Thalassemic Adolescents

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