MGEnrichment: A web application for microglia gene list enrichment analysis.

Gene expression analysis is becoming increasingly utilized in neuro-immunology research, and there is a growing need for non-programming scientists to be able to analyze their own genomic data. MGEnrichment is a web application developed both to disseminate to the community our curated database of m...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Justin Jao, Annie Vogel Ciernia
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/67e8a47c4a4c4c46a3531adcf9f911eb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:67e8a47c4a4c4c46a3531adcf9f911eb
record_format	dspace
spelling	oai:doaj.org-article:67e8a47c4a4c4c46a3531adcf9f911eb2021-12-02T19:57:57ZMGEnrichment: A web application for microglia gene list enrichment analysis.1553-734X1553-735810.1371/journal.pcbi.1009160https://doaj.org/article/67e8a47c4a4c4c46a3531adcf9f911eb2021-11-01T00:00:00Zhttps://doi.org/10.1371/journal.pcbi.1009160https://doaj.org/toc/1553-734Xhttps://doaj.org/toc/1553-7358Gene expression analysis is becoming increasingly utilized in neuro-immunology research, and there is a growing need for non-programming scientists to be able to analyze their own genomic data. MGEnrichment is a web application developed both to disseminate to the community our curated database of microglia-relevant gene lists, and to allow non-programming scientists to easily conduct statistical enrichment analysis on their gene expression data. Users can upload their own gene IDs to assess the relevance of their expression data against gene lists from other studies. We include example datasets of differentially expressed genes (DEGs) from human postmortem brain samples from Autism Spectrum Disorder (ASD) and matched controls. We demonstrate how MGEnrichment can be used to expand the interpretations of these DEG lists in terms of regulation of microglial gene expression and provide novel insights into how ASD DEGs may be implicated specifically in microglial development, microbiome responses and relationships to other neuropsychiatric disorders. This tool will be particularly useful for those working in microglia, autism spectrum disorders, and neuro-immune activation research. MGEnrichment is available at https://ciernialab.shinyapps.io/MGEnrichmentApp/ and further online documentation and datasets can be found at https://github.com/ciernialab/MGEnrichmentApp. The app is released under the GNU GPLv3 open source license.Justin JaoAnnie Vogel CierniaPublic Library of Science (PLoS)articleBiology (General)QH301-705.5ENPLoS Computational Biology, Vol 17, Iss 11, p e1009160 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Justin Jao Annie Vogel Ciernia MGEnrichment: A web application for microglia gene list enrichment analysis.
description	Gene expression analysis is becoming increasingly utilized in neuro-immunology research, and there is a growing need for non-programming scientists to be able to analyze their own genomic data. MGEnrichment is a web application developed both to disseminate to the community our curated database of microglia-relevant gene lists, and to allow non-programming scientists to easily conduct statistical enrichment analysis on their gene expression data. Users can upload their own gene IDs to assess the relevance of their expression data against gene lists from other studies. We include example datasets of differentially expressed genes (DEGs) from human postmortem brain samples from Autism Spectrum Disorder (ASD) and matched controls. We demonstrate how MGEnrichment can be used to expand the interpretations of these DEG lists in terms of regulation of microglial gene expression and provide novel insights into how ASD DEGs may be implicated specifically in microglial development, microbiome responses and relationships to other neuropsychiatric disorders. This tool will be particularly useful for those working in microglia, autism spectrum disorders, and neuro-immune activation research. MGEnrichment is available at https://ciernialab.shinyapps.io/MGEnrichmentApp/ and further online documentation and datasets can be found at https://github.com/ciernialab/MGEnrichmentApp. The app is released under the GNU GPLv3 open source license.
format	article
author	Justin Jao Annie Vogel Ciernia
author_facet	Justin Jao Annie Vogel Ciernia
author_sort	Justin Jao
title	MGEnrichment: A web application for microglia gene list enrichment analysis.
title_short	MGEnrichment: A web application for microglia gene list enrichment analysis.
title_full	MGEnrichment: A web application for microglia gene list enrichment analysis.
title_fullStr	MGEnrichment: A web application for microglia gene list enrichment analysis.
title_full_unstemmed	MGEnrichment: A web application for microglia gene list enrichment analysis.
title_sort	mgenrichment: a web application for microglia gene list enrichment analysis.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/67e8a47c4a4c4c46a3531adcf9f911eb
work_keys_str_mv	AT justinjao mgenrichmentawebapplicationformicrogliagenelistenrichmentanalysis AT annievogelciernia mgenrichmentawebapplicationformicrogliagenelistenrichmentanalysis
_version_	1718375780798431232

MGEnrichment: A web application for microglia gene list enrichment analysis.

Ejemplares similares