Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity

Type 2 diabetes and obesity are associated with increased hepatic gluconeogenesis and lipogenesis, known as selective insulin resistance. Here Kubota et al. explain selective insulin resistance in the liver with the zonal distribution and selective insulin-mediated regulation of Irs1 and Irs2.

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Autores principales:	Naoto Kubota, Tetsuya Kubota, Eiji Kajiwara, Tomokatsu Iwamura, Hiroki Kumagai, Taku Watanabe, Mariko Inoue, Iseki Takamoto, Takayoshi Sasako, Katsuyoshi Kumagai, Motoyuki Kohjima, Makoto Nakamuta, Masao Moroi, Kaoru Sugi, Tetsuo Noda, Yasuo Terauchi, Kohjiro Ueki, Takashi Kadowaki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/67f78d5db20e41daba34da37bdfe2d92
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spelling	oai:doaj.org-article:67f78d5db20e41daba34da37bdfe2d922021-12-02T14:38:54ZDifferential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity10.1038/ncomms129772041-1723https://doaj.org/article/67f78d5db20e41daba34da37bdfe2d922016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms12977https://doaj.org/toc/2041-1723Type 2 diabetes and obesity are associated with increased hepatic gluconeogenesis and lipogenesis, known as selective insulin resistance. Here Kubota et al. explain selective insulin resistance in the liver with the zonal distribution and selective insulin-mediated regulation of Irs1 and Irs2.Naoto KubotaTetsuya KubotaEiji KajiwaraTomokatsu IwamuraHiroki KumagaiTaku WatanabeMariko InoueIseki TakamotoTakayoshi SasakoKatsuyoshi KumagaiMotoyuki KohjimaMakoto NakamutaMasao MoroiKaoru SugiTetsuo NodaYasuo TerauchiKohjiro UekiTakashi KadowakiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Naoto Kubota Tetsuya Kubota Eiji Kajiwara Tomokatsu Iwamura Hiroki Kumagai Taku Watanabe Mariko Inoue Iseki Takamoto Takayoshi Sasako Katsuyoshi Kumagai Motoyuki Kohjima Makoto Nakamuta Masao Moroi Kaoru Sugi Tetsuo Noda Yasuo Terauchi Kohjiro Ueki Takashi Kadowaki Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity
description	Type 2 diabetes and obesity are associated with increased hepatic gluconeogenesis and lipogenesis, known as selective insulin resistance. Here Kubota et al. explain selective insulin resistance in the liver with the zonal distribution and selective insulin-mediated regulation of Irs1 and Irs2.
format	article
author	Naoto Kubota Tetsuya Kubota Eiji Kajiwara Tomokatsu Iwamura Hiroki Kumagai Taku Watanabe Mariko Inoue Iseki Takamoto Takayoshi Sasako Katsuyoshi Kumagai Motoyuki Kohjima Makoto Nakamuta Masao Moroi Kaoru Sugi Tetsuo Noda Yasuo Terauchi Kohjiro Ueki Takashi Kadowaki
author_facet	Naoto Kubota Tetsuya Kubota Eiji Kajiwara Tomokatsu Iwamura Hiroki Kumagai Taku Watanabe Mariko Inoue Iseki Takamoto Takayoshi Sasako Katsuyoshi Kumagai Motoyuki Kohjima Makoto Nakamuta Masao Moroi Kaoru Sugi Tetsuo Noda Yasuo Terauchi Kohjiro Ueki Takashi Kadowaki
author_sort	Naoto Kubota
title	Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity
title_short	Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity
title_full	Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity
title_fullStr	Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity
title_full_unstemmed	Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity
title_sort	differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/67f78d5db20e41daba34da37bdfe2d92
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Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity

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