Aging-related upregulation of the homeobox gene caudal represses intestinal stem cell differentiation in Drosophila.

The differentiation efficiency of adult stem cells undergoes a significant decline in aged animals, which is closely related to the decline in organ function and age-associated diseases. However, the underlying mechanisms that ultimately lead to this observed decline of the differentiation efficienc...

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Autores principales:	Kun Wu, Yiming Tang, Qiaoqiao Zhang, Zhangpeng Zhuo, Xiao Sheng, Jingping Huang, Jie'er Ye, Xiaorong Li, Zhiming Liu, Haiyang Chen
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Genetics QH426-470
Acceso en línea:	https://doaj.org/article/67f983aab95c4367989519d1a6241e17
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spelling	oai:doaj.org-article:67f983aab95c4367989519d1a6241e172021-12-02T20:02:57ZAging-related upregulation of the homeobox gene caudal represses intestinal stem cell differentiation in Drosophila.1553-73901553-740410.1371/journal.pgen.1009649https://doaj.org/article/67f983aab95c4367989519d1a6241e172021-07-01T00:00:00Zhttps://doi.org/10.1371/journal.pgen.1009649https://doaj.org/toc/1553-7390https://doaj.org/toc/1553-7404The differentiation efficiency of adult stem cells undergoes a significant decline in aged animals, which is closely related to the decline in organ function and age-associated diseases. However, the underlying mechanisms that ultimately lead to this observed decline of the differentiation efficiency of stem cells remain largely unclear. This study investigated Drosophila midguts and identified an obvious upregulation of caudal (cad), which encodes a homeobox transcription factor. This factor is traditionally known as a central regulator of embryonic anterior-posterior body axis patterning. This study reports that depletion of cad in intestinal stem/progenitor cells promotes quiescent intestinal stem cells (ISCs) to become activate and produce enterocytes in the midgut under normal gut homeostasis conditions. However, overexpression of cad results in the failure of ISC differentiation and intestinal epithelial regeneration after injury. Moreover, this study suggests that cad prevents intestinal stem/progenitor cell differentiation by modulating the Janus kinase/signal transducers and activators of the transcription pathway and Sox21a-GATAe signaling cascade. Importantly, the reduction of cad expression in intestinal stem/progenitor cells restrained age-associated gut hyperplasia in Drosophila. This study identified a function of the homeobox gene cad in the modulation of adult stem cell differentiation and suggested a potential gene target for the treatment of age-related diseases induced by age-related stem cell dysfunction.Kun WuYiming TangQiaoqiao ZhangZhangpeng ZhuoXiao ShengJingping HuangJie'er YeXiaorong LiZhiming LiuHaiyang ChenPublic Library of Science (PLoS)articleGeneticsQH426-470ENPLoS Genetics, Vol 17, Iss 7, p e1009649 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Genetics QH426-470
spellingShingle	Genetics QH426-470 Kun Wu Yiming Tang Qiaoqiao Zhang Zhangpeng Zhuo Xiao Sheng Jingping Huang Jie'er Ye Xiaorong Li Zhiming Liu Haiyang Chen Aging-related upregulation of the homeobox gene caudal represses intestinal stem cell differentiation in Drosophila.
description	The differentiation efficiency of adult stem cells undergoes a significant decline in aged animals, which is closely related to the decline in organ function and age-associated diseases. However, the underlying mechanisms that ultimately lead to this observed decline of the differentiation efficiency of stem cells remain largely unclear. This study investigated Drosophila midguts and identified an obvious upregulation of caudal (cad), which encodes a homeobox transcription factor. This factor is traditionally known as a central regulator of embryonic anterior-posterior body axis patterning. This study reports that depletion of cad in intestinal stem/progenitor cells promotes quiescent intestinal stem cells (ISCs) to become activate and produce enterocytes in the midgut under normal gut homeostasis conditions. However, overexpression of cad results in the failure of ISC differentiation and intestinal epithelial regeneration after injury. Moreover, this study suggests that cad prevents intestinal stem/progenitor cell differentiation by modulating the Janus kinase/signal transducers and activators of the transcription pathway and Sox21a-GATAe signaling cascade. Importantly, the reduction of cad expression in intestinal stem/progenitor cells restrained age-associated gut hyperplasia in Drosophila. This study identified a function of the homeobox gene cad in the modulation of adult stem cell differentiation and suggested a potential gene target for the treatment of age-related diseases induced by age-related stem cell dysfunction.
format	article
author	Kun Wu Yiming Tang Qiaoqiao Zhang Zhangpeng Zhuo Xiao Sheng Jingping Huang Jie'er Ye Xiaorong Li Zhiming Liu Haiyang Chen
author_facet	Kun Wu Yiming Tang Qiaoqiao Zhang Zhangpeng Zhuo Xiao Sheng Jingping Huang Jie'er Ye Xiaorong Li Zhiming Liu Haiyang Chen
author_sort	Kun Wu
title	Aging-related upregulation of the homeobox gene caudal represses intestinal stem cell differentiation in Drosophila.
title_short	Aging-related upregulation of the homeobox gene caudal represses intestinal stem cell differentiation in Drosophila.
title_full	Aging-related upregulation of the homeobox gene caudal represses intestinal stem cell differentiation in Drosophila.
title_fullStr	Aging-related upregulation of the homeobox gene caudal represses intestinal stem cell differentiation in Drosophila.
title_full_unstemmed	Aging-related upregulation of the homeobox gene caudal represses intestinal stem cell differentiation in Drosophila.
title_sort	aging-related upregulation of the homeobox gene caudal represses intestinal stem cell differentiation in drosophila.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/67f983aab95c4367989519d1a6241e17
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Aging-related upregulation of the homeobox gene caudal represses intestinal stem cell differentiation in Drosophila.

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