Characterizing the replicability of cell types defined by single cell RNA-sequencing data using MetaNeighbor

Single cell RNA-sequencing analysis poses challenges in replication due to technical biases and analytic variability among bioinformatics pipelines. Here, Crow et al develop MetaNeighbor for measuring cell-type replication across datasets, and use it to identify marker genes for neuron subtypes with...

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Auteurs principaux:	Megan Crow, Anirban Paul, Sara Ballouz, Z. Josh Huang, Jesse Gillis
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/67fefc8fb1054363be1ef3aa5f0f083c
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id	oai:doaj.org-article:67fefc8fb1054363be1ef3aa5f0f083c
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spelling	oai:doaj.org-article:67fefc8fb1054363be1ef3aa5f0f083c2021-12-02T15:34:00ZCharacterizing the replicability of cell types defined by single cell RNA-sequencing data using MetaNeighbor10.1038/s41467-018-03282-02041-1723https://doaj.org/article/67fefc8fb1054363be1ef3aa5f0f083c2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03282-0https://doaj.org/toc/2041-1723Single cell RNA-sequencing analysis poses challenges in replication due to technical biases and analytic variability among bioinformatics pipelines. Here, Crow et al develop MetaNeighbor for measuring cell-type replication across datasets, and use it to identify marker genes for neuron subtypes with evidence of replication.Megan CrowAnirban PaulSara BallouzZ. Josh HuangJesse GillisNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Megan Crow Anirban Paul Sara Ballouz Z. Josh Huang Jesse Gillis Characterizing the replicability of cell types defined by single cell RNA-sequencing data using MetaNeighbor
description	Single cell RNA-sequencing analysis poses challenges in replication due to technical biases and analytic variability among bioinformatics pipelines. Here, Crow et al develop MetaNeighbor for measuring cell-type replication across datasets, and use it to identify marker genes for neuron subtypes with evidence of replication.
format	article
author	Megan Crow Anirban Paul Sara Ballouz Z. Josh Huang Jesse Gillis
author_facet	Megan Crow Anirban Paul Sara Ballouz Z. Josh Huang Jesse Gillis
author_sort	Megan Crow
title	Characterizing the replicability of cell types defined by single cell RNA-sequencing data using MetaNeighbor
title_short	Characterizing the replicability of cell types defined by single cell RNA-sequencing data using MetaNeighbor
title_full	Characterizing the replicability of cell types defined by single cell RNA-sequencing data using MetaNeighbor
title_fullStr	Characterizing the replicability of cell types defined by single cell RNA-sequencing data using MetaNeighbor
title_full_unstemmed	Characterizing the replicability of cell types defined by single cell RNA-sequencing data using MetaNeighbor
title_sort	characterizing the replicability of cell types defined by single cell rna-sequencing data using metaneighbor
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/67fefc8fb1054363be1ef3aa5f0f083c
work_keys_str_mv	AT megancrow characterizingthereplicabilityofcelltypesdefinedbysinglecellrnasequencingdatausingmetaneighbor AT anirbanpaul characterizingthereplicabilityofcelltypesdefinedbysinglecellrnasequencingdatausingmetaneighbor AT saraballouz characterizingthereplicabilityofcelltypesdefinedbysinglecellrnasequencingdatausingmetaneighbor AT zjoshhuang characterizingthereplicabilityofcelltypesdefinedbysinglecellrnasequencingdatausingmetaneighbor AT jessegillis characterizingthereplicabilityofcelltypesdefinedbysinglecellrnasequencingdatausingmetaneighbor
_version_	1718386965831745536

Characterizing the replicability of cell types defined by single cell RNA-sequencing data using MetaNeighbor

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