Characterizing the replicability of cell types defined by single cell RNA-sequencing data using MetaNeighbor

Single cell RNA-sequencing analysis poses challenges in replication due to technical biases and analytic variability among bioinformatics pipelines. Here, Crow et al develop MetaNeighbor for measuring cell-type replication across datasets, and use it to identify marker genes for neuron subtypes with...

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Autores principales: Megan Crow, Anirban Paul, Sara Ballouz, Z. Josh Huang, Jesse Gillis
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/67fefc8fb1054363be1ef3aa5f0f083c
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spelling oai:doaj.org-article:67fefc8fb1054363be1ef3aa5f0f083c2021-12-02T15:34:00ZCharacterizing the replicability of cell types defined by single cell RNA-sequencing data using MetaNeighbor10.1038/s41467-018-03282-02041-1723https://doaj.org/article/67fefc8fb1054363be1ef3aa5f0f083c2018-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03282-0https://doaj.org/toc/2041-1723Single cell RNA-sequencing analysis poses challenges in replication due to technical biases and analytic variability among bioinformatics pipelines. Here, Crow et al develop MetaNeighbor for measuring cell-type replication across datasets, and use it to identify marker genes for neuron subtypes with evidence of replication.Megan CrowAnirban PaulSara BallouzZ. Josh HuangJesse GillisNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Megan Crow
Anirban Paul
Sara Ballouz
Z. Josh Huang
Jesse Gillis
Characterizing the replicability of cell types defined by single cell RNA-sequencing data using MetaNeighbor
description Single cell RNA-sequencing analysis poses challenges in replication due to technical biases and analytic variability among bioinformatics pipelines. Here, Crow et al develop MetaNeighbor for measuring cell-type replication across datasets, and use it to identify marker genes for neuron subtypes with evidence of replication.
format article
author Megan Crow
Anirban Paul
Sara Ballouz
Z. Josh Huang
Jesse Gillis
author_facet Megan Crow
Anirban Paul
Sara Ballouz
Z. Josh Huang
Jesse Gillis
author_sort Megan Crow
title Characterizing the replicability of cell types defined by single cell RNA-sequencing data using MetaNeighbor
title_short Characterizing the replicability of cell types defined by single cell RNA-sequencing data using MetaNeighbor
title_full Characterizing the replicability of cell types defined by single cell RNA-sequencing data using MetaNeighbor
title_fullStr Characterizing the replicability of cell types defined by single cell RNA-sequencing data using MetaNeighbor
title_full_unstemmed Characterizing the replicability of cell types defined by single cell RNA-sequencing data using MetaNeighbor
title_sort characterizing the replicability of cell types defined by single cell rna-sequencing data using metaneighbor
publisher Nature Portfolio
publishDate 2018
url https://doaj.org/article/67fefc8fb1054363be1ef3aa5f0f083c
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