Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis

Nephrogenesis ceases after postnatal day 2 in the mouse or after the 36th week of gestation in humans, but how this is regulated is unclear. Here, the authors identify a role for the RNA-binding protein Lin28 and suppression of let-7 microRNA in regulating the duration of nephrogenesis.

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Autores principales:	Alena V. Yermalovich, Jihan K. Osborne, Patricia Sousa, Areum Han, Melissa A. Kinney, Michael J. Chen, Daisy A. Robinton, Helen Montie, Dan S. Pearson, Sean B. Wilson, Alexander N. Combes, Melissa H. Little, George Q. Daley
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/67ffa389fabd4131821bc10193d477ff
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spelling	oai:doaj.org-article:67ffa389fabd4131821bc10193d477ff2021-12-02T15:35:47ZLin28 and let-7 regulate the timing of cessation of murine nephrogenesis10.1038/s41467-018-08127-42041-1723https://doaj.org/article/67ffa389fabd4131821bc10193d477ff2019-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-08127-4https://doaj.org/toc/2041-1723Nephrogenesis ceases after postnatal day 2 in the mouse or after the 36th week of gestation in humans, but how this is regulated is unclear. Here, the authors identify a role for the RNA-binding protein Lin28 and suppression of let-7 microRNA in regulating the duration of nephrogenesis.Alena V. YermalovichJihan K. OsbornePatricia SousaAreum HanMelissa A. KinneyMichael J. ChenDaisy A. RobintonHelen MontieDan S. PearsonSean B. WilsonAlexander N. CombesMelissa H. LittleGeorge Q. DaleyNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Alena V. Yermalovich Jihan K. Osborne Patricia Sousa Areum Han Melissa A. Kinney Michael J. Chen Daisy A. Robinton Helen Montie Dan S. Pearson Sean B. Wilson Alexander N. Combes Melissa H. Little George Q. Daley Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis
description	Nephrogenesis ceases after postnatal day 2 in the mouse or after the 36th week of gestation in humans, but how this is regulated is unclear. Here, the authors identify a role for the RNA-binding protein Lin28 and suppression of let-7 microRNA in regulating the duration of nephrogenesis.
format	article
author	Alena V. Yermalovich Jihan K. Osborne Patricia Sousa Areum Han Melissa A. Kinney Michael J. Chen Daisy A. Robinton Helen Montie Dan S. Pearson Sean B. Wilson Alexander N. Combes Melissa H. Little George Q. Daley
author_facet	Alena V. Yermalovich Jihan K. Osborne Patricia Sousa Areum Han Melissa A. Kinney Michael J. Chen Daisy A. Robinton Helen Montie Dan S. Pearson Sean B. Wilson Alexander N. Combes Melissa H. Little George Q. Daley
author_sort	Alena V. Yermalovich
title	Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis
title_short	Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis
title_full	Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis
title_fullStr	Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis
title_full_unstemmed	Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis
title_sort	lin28 and let-7 regulate the timing of cessation of murine nephrogenesis
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/67ffa389fabd4131821bc10193d477ff
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Lin28 and let-7 regulate the timing of cessation of murine nephrogenesis

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