The OncoPPi network of cancer-focused protein–protein interactions to inform biological insights and therapeutic strategies

The OncoPPi network of cancer-focused protein–protein interactions to inform biological insights and therapeutic strategies

Understanding of dysregulation in cancers requires knowledge, beyond cancer genomes, of the interactions of cancer-associated proteins. Here, the authors use high-throughput, time-resolved FRET to map protein–protein interactions to establish a lung cancer protein network, and demonstrate its utilit...

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Autores principales: Zenggang Li, Andrei A. Ivanov, Rina Su, Valentina Gonzalez-Pecchi, Qi Qi, Songlin Liu, Philip Webber, Elizabeth McMillan, Lauren Rusnak, Cau Pham, Xiaoqian Chen, Xiulei Mo, Brian Revennaugh, Wei Zhou, Adam Marcus, Sahar Harati, Xiang Chen, Margaret A. Johns, Michael A. White, Carlos S. Moreno, Lee A. D. Cooper, Yuhong Du, Fadlo R. Khuri, Haian Fu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/68054ffe48384c37b6507f6dc7acbd25
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spelling oai:doaj.org-article:68054ffe48384c37b6507f6dc7acbd252021-12-02T14:42:38ZThe OncoPPi network of cancer-focused protein–protein interactions to inform biological insights and therapeutic strategies10.1038/ncomms143562041-1723https://doaj.org/article/68054ffe48384c37b6507f6dc7acbd252017-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms14356https://doaj.org/toc/2041-1723Understanding of dysregulation in cancers requires knowledge, beyond cancer genomes, of the interactions of cancer-associated proteins. Here, the authors use high-throughput, time-resolved FRET to map protein–protein interactions to establish a lung cancer protein network, and demonstrate its utility in revealing new oncogenic pathways and connectivity of tumour suppressors with druggable targets.Zenggang LiAndrei A. IvanovRina SuValentina Gonzalez-PecchiQi QiSonglin LiuPhilip WebberElizabeth McMillanLauren RusnakCau PhamXiaoqian ChenXiulei MoBrian RevennaughWei ZhouAdam MarcusSahar HaratiXiang ChenMargaret A. JohnsMichael A. WhiteCarlos S. MorenoLee A. D. CooperYuhong DuFadlo R. KhuriHaian FuNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Zenggang Li
Andrei A. Ivanov
Rina Su
Valentina Gonzalez-Pecchi
Qi Qi
Songlin Liu
Philip Webber
Elizabeth McMillan
Lauren Rusnak
Cau Pham
Xiaoqian Chen
Xiulei Mo
Brian Revennaugh
Wei Zhou
Adam Marcus
Sahar Harati
Xiang Chen
Margaret A. Johns
Michael A. White
Carlos S. Moreno
Lee A. D. Cooper
Yuhong Du
Fadlo R. Khuri
Haian Fu
The OncoPPi network of cancer-focused protein–protein interactions to inform biological insights and therapeutic strategies
description Understanding of dysregulation in cancers requires knowledge, beyond cancer genomes, of the interactions of cancer-associated proteins. Here, the authors use high-throughput, time-resolved FRET to map protein–protein interactions to establish a lung cancer protein network, and demonstrate its utility in revealing new oncogenic pathways and connectivity of tumour suppressors with druggable targets.
format article
author Zenggang Li
Andrei A. Ivanov
Rina Su
Valentina Gonzalez-Pecchi
Qi Qi
Songlin Liu
Philip Webber
Elizabeth McMillan
Lauren Rusnak
Cau Pham
Xiaoqian Chen
Xiulei Mo
Brian Revennaugh
Wei Zhou
Adam Marcus
Sahar Harati
Xiang Chen
Margaret A. Johns
Michael A. White
Carlos S. Moreno
Lee A. D. Cooper
Yuhong Du
Fadlo R. Khuri
Haian Fu
author_facet Zenggang Li
Andrei A. Ivanov
Rina Su
Valentina Gonzalez-Pecchi
Qi Qi
Songlin Liu
Philip Webber
Elizabeth McMillan
Lauren Rusnak
Cau Pham
Xiaoqian Chen
Xiulei Mo
Brian Revennaugh
Wei Zhou
Adam Marcus
Sahar Harati
Xiang Chen
Margaret A. Johns
Michael A. White
Carlos S. Moreno
Lee A. D. Cooper
Yuhong Du
Fadlo R. Khuri
Haian Fu
author_sort Zenggang Li
title The OncoPPi network of cancer-focused protein–protein interactions to inform biological insights and therapeutic strategies
title_short The OncoPPi network of cancer-focused protein–protein interactions to inform biological insights and therapeutic strategies
title_full The OncoPPi network of cancer-focused protein–protein interactions to inform biological insights and therapeutic strategies
title_fullStr The OncoPPi network of cancer-focused protein–protein interactions to inform biological insights and therapeutic strategies
title_full_unstemmed The OncoPPi network of cancer-focused protein–protein interactions to inform biological insights and therapeutic strategies
title_sort oncoppi network of cancer-focused protein–protein interactions to inform biological insights and therapeutic strategies
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/68054ffe48384c37b6507f6dc7acbd25
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