Structural basis for mutually exclusive co-transcriptional nuclear cap-binding complexes with either NELF-E or ARS2

The nuclear cap-binding complex (CBC) binds to the 5′-cap structure of Pol II transcripts. Here, the authors give structural insights into CBC-mediated transcript processing and show that CBC forms mutual exclusive complexes with NELF and ARS2, which might act in earlier and later phases of transcri...

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Autores principales:	Wiebke Manuela Schulze, Stephen Cusack
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/680585e6a9124cdaa5631b37183606df
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spelling	oai:doaj.org-article:680585e6a9124cdaa5631b37183606df2021-12-02T15:36:58ZStructural basis for mutually exclusive co-transcriptional nuclear cap-binding complexes with either NELF-E or ARS210.1038/s41467-017-01402-w2041-1723https://doaj.org/article/680585e6a9124cdaa5631b37183606df2017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01402-whttps://doaj.org/toc/2041-1723The nuclear cap-binding complex (CBC) binds to the 5′-cap structure of Pol II transcripts. Here, the authors give structural insights into CBC-mediated transcript processing and show that CBC forms mutual exclusive complexes with NELF and ARS2, which might act in earlier and later phases of transcription, respectively.Wiebke Manuela SchulzeStephen CusackNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Wiebke Manuela Schulze Stephen Cusack Structural basis for mutually exclusive co-transcriptional nuclear cap-binding complexes with either NELF-E or ARS2
description	The nuclear cap-binding complex (CBC) binds to the 5′-cap structure of Pol II transcripts. Here, the authors give structural insights into CBC-mediated transcript processing and show that CBC forms mutual exclusive complexes with NELF and ARS2, which might act in earlier and later phases of transcription, respectively.
format	article
author	Wiebke Manuela Schulze Stephen Cusack
author_facet	Wiebke Manuela Schulze Stephen Cusack
author_sort	Wiebke Manuela Schulze
title	Structural basis for mutually exclusive co-transcriptional nuclear cap-binding complexes with either NELF-E or ARS2
title_short	Structural basis for mutually exclusive co-transcriptional nuclear cap-binding complexes with either NELF-E or ARS2
title_full	Structural basis for mutually exclusive co-transcriptional nuclear cap-binding complexes with either NELF-E or ARS2
title_fullStr	Structural basis for mutually exclusive co-transcriptional nuclear cap-binding complexes with either NELF-E or ARS2
title_full_unstemmed	Structural basis for mutually exclusive co-transcriptional nuclear cap-binding complexes with either NELF-E or ARS2
title_sort	structural basis for mutually exclusive co-transcriptional nuclear cap-binding complexes with either nelf-e or ars2
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/680585e6a9124cdaa5631b37183606df
work_keys_str_mv	AT wiebkemanuelaschulze structuralbasisformutuallyexclusivecotranscriptionalnuclearcapbindingcomplexeswitheithernelfeorars2 AT stephencusack structuralbasisformutuallyexclusivecotranscriptionalnuclearcapbindingcomplexeswitheithernelfeorars2
_version_	1718386293139832832

Structural basis for mutually exclusive co-transcriptional nuclear cap-binding complexes with either NELF-E or ARS2

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