Outcomes and Prognosis of Non-Elderly Patients with Brain Metastases—A Prospective Cohort Incorporating Individualized Assessment of Heart Rate Variability

Outcomes and prognostic factors among patients with brain metastases (BM) have been widely studied, but seldom for the non-elderly. Heart rate variability (HRV) is a physiological phenomenon and has been shown as a survival prognostic factor in cancer patients. This study aimed to evaluate the outco...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Yu-Ming Wang, Jen-Yu Cheng, Chong-Jong Wang, Shu-Shya Hseu, Eng-Yen Huang
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	brain metastases non-elderly age heart rate variability radiotherapy prognosis Medicine R
Acceso en línea:	https://doaj.org/article/6808b35f50784d4483a6f953177a0ab4
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:6808b35f50784d4483a6f953177a0ab4
record_format	dspace
spelling	oai:doaj.org-article:6808b35f50784d4483a6f953177a0ab42021-11-25T18:06:43ZOutcomes and Prognosis of Non-Elderly Patients with Brain Metastases—A Prospective Cohort Incorporating Individualized Assessment of Heart Rate Variability10.3390/jpm111110492075-4426https://doaj.org/article/6808b35f50784d4483a6f953177a0ab42021-10-01T00:00:00Zhttps://www.mdpi.com/2075-4426/11/11/1049https://doaj.org/toc/2075-4426Outcomes and prognostic factors among patients with brain metastases (BM) have been widely studied, but seldom for the non-elderly. Heart rate variability (HRV) is a physiological phenomenon and has been shown as a survival prognostic factor in cancer patients. This study aimed to evaluate the outcomes and prognosis among non-elderly BM patients with the incorporation of HRV analysis. Forty non-elderly BM patients treated using whole brain radiotherapy (WBRT) were studied from January 2010 prospectively with 5-min electrocardiography (ECG) recordings. Individualized HRV was generated by the ECG, and the time domain HRV index SDNN was chosen for survival analysis. The median overall survival (OS) for the entire group was 6.21 months. Univariate analysis revealed that a KPS < 80 (<i>p</i> = 0.019) and an SDNN < 10 ms (<i>p</i> = 0.007) demonstrated statistical significance for OS; multivariate analysis confirmed that a KPS < 80 (<i>p</i> = 0.004; HR = 3.060, CI = 1.437–6.517) and an SDNN < 10 ms (<i>p</i> = 0.010; HR = 2.664, CI = 1.262–5.624) were independent prognostic factors. Prospective studies for risk stratification among non-elderly BM patients based on our results are warranted to validate our findings.Yu-Ming WangJen-Yu ChengChong-Jong WangShu-Shya HseuEng-Yen HuangMDPI AGarticlebrain metastasesnon-elderlyageheart rate variabilityradiotherapyprognosisMedicineRENJournal of Personalized Medicine, Vol 11, Iss 1049, p 1049 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	brain metastases non-elderly age heart rate variability radiotherapy prognosis Medicine R
spellingShingle	brain metastases non-elderly age heart rate variability radiotherapy prognosis Medicine R Yu-Ming Wang Jen-Yu Cheng Chong-Jong Wang Shu-Shya Hseu Eng-Yen Huang Outcomes and Prognosis of Non-Elderly Patients with Brain Metastases—A Prospective Cohort Incorporating Individualized Assessment of Heart Rate Variability
description	Outcomes and prognostic factors among patients with brain metastases (BM) have been widely studied, but seldom for the non-elderly. Heart rate variability (HRV) is a physiological phenomenon and has been shown as a survival prognostic factor in cancer patients. This study aimed to evaluate the outcomes and prognosis among non-elderly BM patients with the incorporation of HRV analysis. Forty non-elderly BM patients treated using whole brain radiotherapy (WBRT) were studied from January 2010 prospectively with 5-min electrocardiography (ECG) recordings. Individualized HRV was generated by the ECG, and the time domain HRV index SDNN was chosen for survival analysis. The median overall survival (OS) for the entire group was 6.21 months. Univariate analysis revealed that a KPS < 80 (<i>p</i> = 0.019) and an SDNN < 10 ms (<i>p</i> = 0.007) demonstrated statistical significance for OS; multivariate analysis confirmed that a KPS < 80 (<i>p</i> = 0.004; HR = 3.060, CI = 1.437–6.517) and an SDNN < 10 ms (<i>p</i> = 0.010; HR = 2.664, CI = 1.262–5.624) were independent prognostic factors. Prospective studies for risk stratification among non-elderly BM patients based on our results are warranted to validate our findings.
format	article
author	Yu-Ming Wang Jen-Yu Cheng Chong-Jong Wang Shu-Shya Hseu Eng-Yen Huang
author_facet	Yu-Ming Wang Jen-Yu Cheng Chong-Jong Wang Shu-Shya Hseu Eng-Yen Huang
author_sort	Yu-Ming Wang
title	Outcomes and Prognosis of Non-Elderly Patients with Brain Metastases—A Prospective Cohort Incorporating Individualized Assessment of Heart Rate Variability
title_short	Outcomes and Prognosis of Non-Elderly Patients with Brain Metastases—A Prospective Cohort Incorporating Individualized Assessment of Heart Rate Variability
title_full	Outcomes and Prognosis of Non-Elderly Patients with Brain Metastases—A Prospective Cohort Incorporating Individualized Assessment of Heart Rate Variability
title_fullStr	Outcomes and Prognosis of Non-Elderly Patients with Brain Metastases—A Prospective Cohort Incorporating Individualized Assessment of Heart Rate Variability
title_full_unstemmed	Outcomes and Prognosis of Non-Elderly Patients with Brain Metastases—A Prospective Cohort Incorporating Individualized Assessment of Heart Rate Variability
title_sort	outcomes and prognosis of non-elderly patients with brain metastases—a prospective cohort incorporating individualized assessment of heart rate variability
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/6808b35f50784d4483a6f953177a0ab4
work_keys_str_mv	AT yumingwang outcomesandprognosisofnonelderlypatientswithbrainmetastasesaprospectivecohortincorporatingindividualizedassessmentofheartratevariability AT jenyucheng outcomesandprognosisofnonelderlypatientswithbrainmetastasesaprospectivecohortincorporatingindividualizedassessmentofheartratevariability AT chongjongwang outcomesandprognosisofnonelderlypatientswithbrainmetastasesaprospectivecohortincorporatingindividualizedassessmentofheartratevariability AT shushyahseu outcomesandprognosisofnonelderlypatientswithbrainmetastasesaprospectivecohortincorporatingindividualizedassessmentofheartratevariability AT engyenhuang outcomesandprognosisofnonelderlypatientswithbrainmetastasesaprospectivecohortincorporatingindividualizedassessmentofheartratevariability
_version_	1718411619602530304

Outcomes and Prognosis of Non-Elderly Patients with Brain Metastases—A Prospective Cohort Incorporating Individualized Assessment of Heart Rate Variability

Ejemplares similares