Topical Cannabinoids for Treating Chemotherapy-Induced Neuropathy: A Case Series

Background Chemotherapy-induced peripheral neuropathy is a common and often severe side effect from many chemotherapeutic agents, with limited treatment options. There is no literature on the use of topical cannabinoids for chemotherapy-induced neuropathy. Case Presentations The current manuscript p...

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Autores principales:	Stacy D’Andre MD, Sean McAllister PhD, Jasdeepa Nagi MD, Karthik V. Giridhar MD, Eduardo Ruiz-Macias, Charles Loprinzi MD
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/680a7ed09ea044b5ad5b8002a8c857cf
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spelling	oai:doaj.org-article:680a7ed09ea044b5ad5b8002a8c857cf2021-12-02T01:03:28ZTopical Cannabinoids for Treating Chemotherapy-Induced Neuropathy: A Case Series1534-73541552-695X10.1177/15347354211061739https://doaj.org/article/680a7ed09ea044b5ad5b8002a8c857cf2021-11-01T00:00:00Zhttps://doi.org/10.1177/15347354211061739https://doaj.org/toc/1534-7354https://doaj.org/toc/1552-695XBackground Chemotherapy-induced peripheral neuropathy is a common and often severe side effect from many chemotherapeutic agents, with limited treatment options. There is no literature on the use of topical cannabinoids for chemotherapy-induced neuropathy. Case Presentations The current manuscript presents a case series of patients presenting in oncology clinics at Sutter Health, CA and Mayo Clinic, Rochester, MN from April 2019 to December 2020 with chemotherapy-induced peripheral neuropathy who used topical creams containing the cannabinoids delta-nine-tetrahydrocannabinol (THC) and/or cannabidiol (CBD). Conclusions This case series suggests that topical cannabinoids may be helpful for patients with chemotherapy-induced peripheral neuropathy. This paper also discusses the potential mechanisms of action by which topical cannabinoids might alleviate established CIPN symptoms. A randomized placebo-controlled trial using a standardized product is planned to study the actual efficacy of such treatment.Stacy D’Andre MDSean McAllister PhDJasdeepa Nagi MDKarthik V. Giridhar MDEduardo Ruiz-MaciasCharles Loprinzi MDSAGE PublishingarticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENIntegrative Cancer Therapies, Vol 20 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Stacy D’Andre MD Sean McAllister PhD Jasdeepa Nagi MD Karthik V. Giridhar MD Eduardo Ruiz-Macias Charles Loprinzi MD Topical Cannabinoids for Treating Chemotherapy-Induced Neuropathy: A Case Series
description	Background Chemotherapy-induced peripheral neuropathy is a common and often severe side effect from many chemotherapeutic agents, with limited treatment options. There is no literature on the use of topical cannabinoids for chemotherapy-induced neuropathy. Case Presentations The current manuscript presents a case series of patients presenting in oncology clinics at Sutter Health, CA and Mayo Clinic, Rochester, MN from April 2019 to December 2020 with chemotherapy-induced peripheral neuropathy who used topical creams containing the cannabinoids delta-nine-tetrahydrocannabinol (THC) and/or cannabidiol (CBD). Conclusions This case series suggests that topical cannabinoids may be helpful for patients with chemotherapy-induced peripheral neuropathy. This paper also discusses the potential mechanisms of action by which topical cannabinoids might alleviate established CIPN symptoms. A randomized placebo-controlled trial using a standardized product is planned to study the actual efficacy of such treatment.
format	article
author	Stacy D’Andre MD Sean McAllister PhD Jasdeepa Nagi MD Karthik V. Giridhar MD Eduardo Ruiz-Macias Charles Loprinzi MD
author_facet	Stacy D’Andre MD Sean McAllister PhD Jasdeepa Nagi MD Karthik V. Giridhar MD Eduardo Ruiz-Macias Charles Loprinzi MD
author_sort	Stacy D’Andre MD
title	Topical Cannabinoids for Treating Chemotherapy-Induced Neuropathy: A Case Series
title_short	Topical Cannabinoids for Treating Chemotherapy-Induced Neuropathy: A Case Series
title_full	Topical Cannabinoids for Treating Chemotherapy-Induced Neuropathy: A Case Series
title_fullStr	Topical Cannabinoids for Treating Chemotherapy-Induced Neuropathy: A Case Series
title_full_unstemmed	Topical Cannabinoids for Treating Chemotherapy-Induced Neuropathy: A Case Series
title_sort	topical cannabinoids for treating chemotherapy-induced neuropathy: a case series
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/680a7ed09ea044b5ad5b8002a8c857cf
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Topical Cannabinoids for Treating Chemotherapy-Induced Neuropathy: A Case Series

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