Au Catalyzing Control Release NO in vivo and Tumor Growth-Inhibiting Effect in Chemo-Photothermal Combination Therapy

Ying Zhang,1 Tianfu Zhou,1 Jian Li,1 Nuo Xu,1 Mingze Cai,1 Hong Zhang,2 Qinfu Zhao,3 Siling Wang3 1Key Laboratory of TargetDrug Design and Research, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, People’s Republic of China; 2Van ’T Hoff Institute for...

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Autores principales:	Zhang Y, Zhou T, Li J, Xu N, Cai M, Zhang H, Zhao Q, Wang S
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	thermotherapy chemotherapy no control release magnetic mesoporous silica Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/680ee0dc3f514e11a0ed4429531fd05a
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spelling	oai:doaj.org-article:680ee0dc3f514e11a0ed4429531fd05a2021-12-02T18:19:07ZAu Catalyzing Control Release NO in vivo and Tumor Growth-Inhibiting Effect in Chemo-Photothermal Combination Therapy1178-2013https://doaj.org/article/680ee0dc3f514e11a0ed4429531fd05a2021-03-01T00:00:00Zhttps://www.dovepress.com/au-catalyzing-control-release-no-in-vivo-and-tumor-growth-inhibiting-e-peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Ying Zhang,1 Tianfu Zhou,1 Jian Li,1 Nuo Xu,1 Mingze Cai,1 Hong Zhang,2 Qinfu Zhao,3 Siling Wang3 1Key Laboratory of TargetDrug Design and Research, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, People’s Republic of China; 2Van ’T Hoff Institute for Molecular Sciences, University of Amsterdam, Amsterdam, 1098 XH, the Netherlands; 3Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, People’s Republic of ChinaCorrespondence: Qinfu Zhao; Siling Wang Tel/Fax +86 24 43520555Email qinfuzhao@syphu.edu.cn; silingwang@syphu.edu.cnIntroduction: Aim to obtain a NO donor that can control released NO in vivo with the high efficacy of tumor suppression and targeting, a nanoplatform consisting of FA-Fe3O4@mSiO2-Au/DOX was constructed.Methods: In vitro, the nanoplatform catalyzed NO’s release with the maximum value of 4.91 μM within 60 min at 43°C pH=5.0, which was increased by 1.14 times when the temperature was 37°C. In vivo, 11.7 μg Au in the tumor tissue was found to catalyze S-nitrosoglutathione continuously, and 54 μM NO was checked out in the urine.Results and Discussion: The high concentration of NO was found to increase the apoptotic rate and to reduce tumor proliferation. In the chemo-photothermal combination therapy, the tumor inhibition rate was increased up to 94.3%, and Au’s contribution from catalyzing NO release NO was 8.17%.Keywords: thermotherapy, chemotherapy, NO control release, magnetic mesoporous silica nanocompositesZhang YZhou TLi JXu NCai MZhang HZhao QWang SDove Medical Pressarticlethermotherapychemotherapyno control releasemagnetic mesoporous silicaMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol Volume 16, Pp 2501-2513 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	thermotherapy chemotherapy no control release magnetic mesoporous silica Medicine (General) R5-920
spellingShingle	thermotherapy chemotherapy no control release magnetic mesoporous silica Medicine (General) R5-920 Zhang Y Zhou T Li J Xu N Cai M Zhang H Zhao Q Wang S Au Catalyzing Control Release NO in vivo and Tumor Growth-Inhibiting Effect in Chemo-Photothermal Combination Therapy
description	Ying Zhang,1 Tianfu Zhou,1 Jian Li,1 Nuo Xu,1 Mingze Cai,1 Hong Zhang,2 Qinfu Zhao,3 Siling Wang3 1Key Laboratory of TargetDrug Design and Research, Ministry of Education, Shenyang Pharmaceutical University, Shenyang, 110016, People’s Republic of China; 2Van ’T Hoff Institute for Molecular Sciences, University of Amsterdam, Amsterdam, 1098 XH, the Netherlands; 3Department of Pharmaceutics, School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, 110016, People’s Republic of ChinaCorrespondence: Qinfu Zhao; Siling Wang Tel/Fax +86 24 43520555Email qinfuzhao@syphu.edu.cn; silingwang@syphu.edu.cnIntroduction: Aim to obtain a NO donor that can control released NO in vivo with the high efficacy of tumor suppression and targeting, a nanoplatform consisting of FA-Fe3O4@mSiO2-Au/DOX was constructed.Methods: In vitro, the nanoplatform catalyzed NO’s release with the maximum value of 4.91 μM within 60 min at 43°C pH=5.0, which was increased by 1.14 times when the temperature was 37°C. In vivo, 11.7 μg Au in the tumor tissue was found to catalyze S-nitrosoglutathione continuously, and 54 μM NO was checked out in the urine.Results and Discussion: The high concentration of NO was found to increase the apoptotic rate and to reduce tumor proliferation. In the chemo-photothermal combination therapy, the tumor inhibition rate was increased up to 94.3%, and Au’s contribution from catalyzing NO release NO was 8.17%.Keywords: thermotherapy, chemotherapy, NO control release, magnetic mesoporous silica nanocomposites
format	article
author	Zhang Y Zhou T Li J Xu N Cai M Zhang H Zhao Q Wang S
author_facet	Zhang Y Zhou T Li J Xu N Cai M Zhang H Zhao Q Wang S
author_sort	Zhang Y
title	Au Catalyzing Control Release NO in vivo and Tumor Growth-Inhibiting Effect in Chemo-Photothermal Combination Therapy
title_short	Au Catalyzing Control Release NO in vivo and Tumor Growth-Inhibiting Effect in Chemo-Photothermal Combination Therapy
title_full	Au Catalyzing Control Release NO in vivo and Tumor Growth-Inhibiting Effect in Chemo-Photothermal Combination Therapy
title_fullStr	Au Catalyzing Control Release NO in vivo and Tumor Growth-Inhibiting Effect in Chemo-Photothermal Combination Therapy
title_full_unstemmed	Au Catalyzing Control Release NO in vivo and Tumor Growth-Inhibiting Effect in Chemo-Photothermal Combination Therapy
title_sort	au catalyzing control release no in vivo and tumor growth-inhibiting effect in chemo-photothermal combination therapy
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/680ee0dc3f514e11a0ed4429531fd05a
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Au Catalyzing Control Release NO in vivo and Tumor Growth-Inhibiting Effect in Chemo-Photothermal Combination Therapy

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