Targeted inhibition of the COP9 signalosome for treatment of cancer

Dysregulation of protein degradation by the ubiquitin-proteasome system is a feature commonly associated with cancer. Here, the authors develop an orally available small molecule that inhibits CSN5, the proteolytic subunit of the COP9 signalosome, and blocks tumour growth in a xenograft model.

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Autores principales:	Anita Schlierf, Eva Altmann, Jean Quancard, Anne B. Jefferson, René Assenberg, Martin Renatus, Matthew Jones, Ulrich Hassiepen, Michael Schaefer, Michael Kiffe, Andreas Weiss, Christian Wiesmann, Richard Sedrani, Jörg Eder, Bruno Martoglio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/6813730e8c8647398b624ca609051b9b
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spelling	oai:doaj.org-article:6813730e8c8647398b624ca609051b9b2021-12-02T14:39:53ZTargeted inhibition of the COP9 signalosome for treatment of cancer10.1038/ncomms131662041-1723https://doaj.org/article/6813730e8c8647398b624ca609051b9b2016-10-01T00:00:00Zhttps://doi.org/10.1038/ncomms13166https://doaj.org/toc/2041-1723Dysregulation of protein degradation by the ubiquitin-proteasome system is a feature commonly associated with cancer. Here, the authors develop an orally available small molecule that inhibits CSN5, the proteolytic subunit of the COP9 signalosome, and blocks tumour growth in a xenograft model.Anita SchlierfEva AltmannJean QuancardAnne B. JeffersonRené AssenbergMartin RenatusMatthew JonesUlrich HassiepenMichael SchaeferMichael KiffeAndreas WeissChristian WiesmannRichard SedraniJörg EderBruno MartoglioNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Anita Schlierf Eva Altmann Jean Quancard Anne B. Jefferson René Assenberg Martin Renatus Matthew Jones Ulrich Hassiepen Michael Schaefer Michael Kiffe Andreas Weiss Christian Wiesmann Richard Sedrani Jörg Eder Bruno Martoglio Targeted inhibition of the COP9 signalosome for treatment of cancer
description	Dysregulation of protein degradation by the ubiquitin-proteasome system is a feature commonly associated with cancer. Here, the authors develop an orally available small molecule that inhibits CSN5, the proteolytic subunit of the COP9 signalosome, and blocks tumour growth in a xenograft model.
format	article
author	Anita Schlierf Eva Altmann Jean Quancard Anne B. Jefferson René Assenberg Martin Renatus Matthew Jones Ulrich Hassiepen Michael Schaefer Michael Kiffe Andreas Weiss Christian Wiesmann Richard Sedrani Jörg Eder Bruno Martoglio
author_facet	Anita Schlierf Eva Altmann Jean Quancard Anne B. Jefferson René Assenberg Martin Renatus Matthew Jones Ulrich Hassiepen Michael Schaefer Michael Kiffe Andreas Weiss Christian Wiesmann Richard Sedrani Jörg Eder Bruno Martoglio
author_sort	Anita Schlierf
title	Targeted inhibition of the COP9 signalosome for treatment of cancer
title_short	Targeted inhibition of the COP9 signalosome for treatment of cancer
title_full	Targeted inhibition of the COP9 signalosome for treatment of cancer
title_fullStr	Targeted inhibition of the COP9 signalosome for treatment of cancer
title_full_unstemmed	Targeted inhibition of the COP9 signalosome for treatment of cancer
title_sort	targeted inhibition of the cop9 signalosome for treatment of cancer
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/6813730e8c8647398b624ca609051b9b
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Targeted inhibition of the COP9 signalosome for treatment of cancer

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