Retinal orientation and interactions in rhodopsin reveal a two-stage trigger mechanism for activation
Rhodopsin signalling is triggered by the light-induced isomerization of its 11-cisretinal chromophore. Here, the authors use NMR spectroscopy to define retinal orientation and interactions in the active metarhodopsin II intermediate, proposing a two-stage mechanism for rhodopsin activation.
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| Autores principales: | , , , , , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2016
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/68145e548cf44632bc7c5e853a70c0e6 |
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| Sumario: | Rhodopsin signalling is triggered by the light-induced isomerization of its 11-cisretinal chromophore. Here, the authors use NMR spectroscopy to define retinal orientation and interactions in the active metarhodopsin II intermediate, proposing a two-stage mechanism for rhodopsin activation. |
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